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DESCRIPTIONprovided by applicantThe Cell SafeTM is a fundamentally new approach in replacement of dysfunctional insulin producing cells in patients with diabetesby transplantation of new islets in a three dimensional scaffold embedded in a highly compatible bioengineered perfusion system that continuously supplies tissue fluidblood ultrafiltrateso that the cells ae protected from immune rejection ...

ABSTRACT The estimates of natural product producing gene clusters within the genomes of microorganisms are far greater than the number of known natural products indicating that there is a wealth of untapped molecules within these organisms that offer huge potential as leads for new medicines Unfortunately the prevailing paradigms for natural product discovery are ill suited for accessing this ...

Project Summary Abstract Phenylketonuria PKU is a serious inborn metabolic disorder affecting out of every children born in the U S annually Characteristic effect of PKU is the impaired capability of the body to convert the amino acid phenylalanine Phe to tyrosine and as a result Phe level is elevated in the blood stream While Phe is required for normal growth and brain developm ...

There is a fundamental knowledge gap in how to immediately reduce cancer patientstreatment related financial burdenCancer patients pay more out of pocket for their care than those with other chronic illnessesHalf of all elderly cancer patients have high treatment related out of pocket financial burdenThis financial burden has well defined harmful effects even among insured cancer patients includin ...

Glaucoma is one of the leading causes of blindness in the world This chronic and progressive optic neuropathy is characterized by loss of axons of the retinal ganglion cells RGC that constitute the optic nerve Reduction of elevated intraocular pressure the only modifiable causative factor slow the onset and progression of the disease yet no treatment is available to restore o ...

In the United States over million people are incarcerated While these numbers are alarming even more distressing is the rapid growth in the number of mentally ill individuals caught in this system Within any given year approximately of females and of males in jail will experience a mental health problem This results in the criminal justice system serving as a de facto mental ...

Neonatal hypoxia ischemiaHIremains a major cause of acute perinatal brain injuryleading ultimately to neurologic dysfunction manifesting as cerebral palsymental retardationand epilepsyUnfortunatelycurrent treatment and prevention strategies in newborns are limitedThere are no currently available therapies to prevent treat and or attenuate brain damage in premature infants other than supportive car ...

Project SummaryAbstractThe methods of optogenetics enable light inducedarea confined stimulation or inhibition of genetically targeted neuronsthereby bypassing key disadvantages of electrical approachesAs a resultoptogenetics is now widely viewed as an essential tool in neuroscience researchThe adoption of these methods by the community is rapidly increasingin spite of the required use of an expen ...

Uncontrolled bleeding remains one of the leading causes of trauma induced death Current treatment recommendations focus on fresh frozen plasma and blood cell transfusions which do not seem to be effective Over the last few years these is increasing use of prothrombin complex cencentrate to treat hemorrhage associated coagulapathy which is effective but induces disseminated intravascular coagula ...

ABSTRACT Alzheimerandapos s and other tauopathies are medical problems growing to historical proportions that threaten the long term viability of medical care systems world wide Alzheimerandapos s costs today are of the US GDP and growing as the population ages Effective disease modifying treatments have yet to be developed A number of drugs in clinical testing target amyloid but very fe ...