Award Data

The speed resolution and high mass accuracy of modern mass spectrometers have revolutionized proteomics particularly for determining fragile post translational modifications that control most cellular processes Accurate identification and quantitation of phosphorylation sites remain a major challenge in proteomics The key weakness with mass spectrometry for phospho proteomics lies in the metho ...

DESCRIPTION provided by applicant The long term goal of this project is to reduce falls in older adults by improving their ability to recover equilibrium during a slip or trip The proposed strategy is to use AMES an FDA cleared non invasive intervention that has been shown to enhance motor performance in able bodied adults and to reduce sensorimotor impairment in both the upper and lower lim ...

The proposed Dynamic Mining and Contextualization of the Scientific Literature DMCSL provides an open lane of communication between authors science journals readers and databases The outcome of this communication portal will be a database containing mineable metadata for researchers reagent supply and biotech companies Data will be available to companies through individualized subscription ...

The overarching goal of the proposed research is to demonstrate the feasibility of modifying an existing effective computer based tobacco prevention program Click City Tobacco funded by NIH R CA to prevent the initiation of e cigarette use e g e cigarettes and other vaping devices among youth Click City Tobacco is a school based program for th graders with a booster in th ...

Abstract Although an efficient prophylactic vaccine is available for hepatitis B virus HBV chronic hepatitis B CHB affects up to million people worldwide and despite advances remains mostly incurable In adults acute HBV infection is cleared in of cases by CD T cell mediated mechanisms but chronic lifelong infection ensues in the remaining individuals which can lead to liver ci ...

ABSTRACT Adolescents in the juvenile justice system demonstrate very high rates of tobacco alcohol and other drug use ATOD with rates that are estimated to be three times higher than non justice involved youth Substance abusing youth especially those who are involved in the juvenile justice system are at higher risk than nonusers for mental health problems including depression conduct ...

This SBIR Fast Track application focuses on the development of a nanoconstruct for co delivery of siRNA and chemotherapy drugs to drug resistant human epidermal growth factor receptor type positive HER breast cancer HER breast cancer is a subtype that presents HER overexpression and accounts for of invasive breast cancers HER breast cancer has poor prognosis despite the rigorou ...

Nearly half of all biomedical publications ever written have been published in the last years the era since the completion of the human genome project The rate of increase is exponential shows no signs of slowing down and can be seen in all of the information sources relevant to precision medicine development This constitutes a nearly insurmountable burden for the drug development and diag ...

ABSTRACT SUMMARY The outcome of this phase project will yield a turnkey system for spectroscopy polarimetry in the terahertz THz frequency range designed to support development of new drugs This system will directly probe protein vibrations using polarized terahertz radiation allowing researchers to rapidly characterize intramolecular vibrations which will help identify sites on ...

Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...