Award Data

Necrotizing enterocolitis (NEC) is a devastating acute inflammatory condition of the gastrointestinal tract resulting in intestinal necrosis, systemic sepsis and multi-system organ failure found mostly in infants born prematurely. Despite modern medical advances in the past decade, the etiology remains elusive and morbidity and mortality are still unacceptably high. It has been concluded that the ...

PROJECT ABSTRACT Although rt11 million family/friends are caregivers to rt6 million people with Alzheimer's Disease (AD) and AD- Related Dementias (AD/ADRD), they do not typically receive personalized education, strategies and support to manage their own wellbeing and complex dementia-related symptoms. Lack of personalized care contributes to $321 billion annually in AD/ADRD care costs. In respons ...

Summary Climate change is an urgent public health threat, and climate-related health risks disproportionately impact vulnerable populations. Public health agencies have underscored the need to develop scalable and innovative health-equity centered, multi-level interventions that offer tools and resources to 1) raise awareness of the inextricable link between climate change and health and 2) suppor ...

The MAI team is developing a solution for a portable expeditionary AN/UYQ-100 USW-DSS unit that will have standalone and integrated Consolidated Afloat Network Enterprise Services (CANES) capabilities to further enhance individual unit and watchteam team ASW & ASUW capabilities. The MAI team will incorporate a robust embedded interactive training curriculum applicable to operators and supervisors. ...

Mine countermeasure (MCM) operations employ neutralizers with a small explosive charge to engage naval mines. During the engagement, the neutralizer approaches a targeted mine and detonates its explosive charge, which can cause a sympathetic detonation or lower-order reaction in the naval mine. Battle damage assessment (BDA) to determine the outcome of the attack currently requires a follow-on mis ...

Propel proposes to conduct research in order to determine the performance level of a seamless cold weather mesh undershirt and drawers as compared to the existing undershirt and drawers.  Propel shall develop initial concepts and evaluate their technical feasibility.  Comparison to conventionally sewn seams using internationally recognized standards and test methods, as well as novel test method ...

BTech proposes a directional hydrophone for acoustic noise measurements for various host platforms including floats, gliders, and observation buoys. The BTech design is provided in Phase I report including sensing concept and configuration, mechanical packing, power consumption, communication interfaces, sensor (re)calibration methodology, algorithms to extract the information content of the ocean ...

ABSTRACT The identification and removal of process-related protein impurities (PRPI) from biologic products is a critical step in drug development. Despite recent improvements in the purification and processing of biologics, the presence of immunogenic PRPI continue to raise concerns about drug safety and efficacy. We propose an innovative approach for assessing immunogenicity risk of PRPI using o ...

It is estimated that approximately 5-10% of all diagnosed cancers are caused by Hereditary Cancer Syndromes (HCS) that are associated with germline mutations (inherited genetic mutations passed directly from a parent to a child that create a genetic predisposition to certain types of cancer). Recent epidemiologic models indicate that 1 in 279 people may be carriers of one of the most common HCS, a ...

Modern pharmaceuticals have greatly improved the quality of life for many patients suffering a variety of illnesses. Unfortunately, among the 17 most commonly prescribed drugs, only 6 are highly effective for most patients, 5 have a modest effect, and 6 show little clinical effect. Worse still, unwanted illness and death from treatment of patients with the incorrect drug or dosage causes over 275, ...