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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Developing Testing and Validating a Wearable Alcohol Biosensor

    SBC: Clinitech, LLC            Topic: 450

    PROJECT SUMMARY This application for a Phase I SBIR award represents a collaboration between Clinitech LLC and McLean Hospital Harvard Medical School to develop a wearable biosensor for detecting alcohol in the interstitial fluid of humans who have consumed alcohol Excessive use of alcohol accounts for much of the public health burden related to alcohol use disorders including fetal ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Multi Scale In Vitro D Tissue Model of Vascularized Bone Cartilage Interactions

    SBC: CFD Research Corporation            Topic: NIAMS

    Abstract Current in vitro models of vascularized bone tissues do not mimic the in vivo microenvironment comprising of diverse cell types in communication with each other through stromal barriers In addition they are hampered by lack of real time visualization and quantitation of vasculature bone as well as bone cartilage interactions In contrast animal models while providing useful information ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Humanized Kidney Cellular Toxicity Platforms

    SBC: DISCOVERYBIOMED, INC.            Topic: NIEHS

    Principal Investigators for Small Business DiscoveryBioMed Inc DBM Project Summary Abstract The over arching goal of this proposed SBIR driven program is to create relevant DiscoveryBioMed DBM human cellular toxicity HCT platforms for the kidney grown in D and in D cell culture formats for a new gold standard in lead therapeutic asset and materials in vitro testing and to reduce marke ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Coating to enhance endothelialization after left atrial appendage closure

    SBC: ENDOMIMETICS, LLC            Topic: NHLBI

    The prevalence of atrial fibrillation in the US is approximately to million putting patients at significantly increased risk of cardioembolic stroke Approximately of all strokes are caused by atrial fibrillation Most atrial fibrillation is treated with blood thinners however some patients are at such high risk of bleeding that it prohibits anticoagulation Left atrial appendage ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Novel Mitochondrial DNA Repair Enzyme for Heart Failure

    SBC: EXSCIEN CORPORATION            Topic: NHLBI

    ABSTRACT Previous studies have demonstrated that heart failure triggers and sustains increases in oxidative stress inducing mitochondrial DNA mtDNA damage that then propagates myocardial injury resulting in cardiac dysfunction and myocardial cell death Fortunately mtDNA injury is reparable via endogenous base excision repair BER mechanisms The rate limiting step within BER is the amount of ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. ESTABLISHMENT OF D HUMAN TISSUE CULTURE MODEL SYSTEM FOR ADVANCING BREAST CANCER

    SBC: Tatva Biosciences, LLC            Topic: NCI

    Despite the recognition of obvious breast cancer BC racial health disparity we have failed to reduce the BC outcome gaps in African American women Unavailability of three dimensional D tissue culture model systems that mimics the original tumor s architecture and molecular characteristics of the racially disparate breast tumors limits our advancement in this area The overall goal of this S ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. SMARTPLATE TECHNOLOGY FOR ADVANCED CELLULAR STAC M

    SBC: CFD Research Corporation            Topic: NIDA

    This project will develop design fabricate test and demonstrate a novel SmartPlate Technology for Advanced Cell based Models STAC M The STAC M technology will be demonstrated for both current static culture and next generation cell based assays The proposed effort features a collaboration between CFD Research Corporation and Vanderbilt University and builds on several critical element ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Development of a Non adjuvanted VLP Vaccine against Stealth H N Influenza

    SBC: EPIVAX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The avian origin H N influenza virus that emerged in humans in China in presents a unique challenge to vaccine development because it is poorly immunogenic Neutralizing antibodies are not detected in acute phase infection Anti H antibody responses are significantly delayed and exhibit low avidity in comparison with antibodies generated following seas ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Multi Source E Beam kV X Ray Tube for Image Guided Radiotheraphy

    SBC: TELESECURITY SCIENCES, INC.            Topic: 102

    DESCRIPTION provided by applicant This project will develop a commercial product that will enable for the first time realtime tumor tracking during radiotherapy at an attractive price point and with minimal interference with standard clinical practice The key novel technology is an optimized multi source X ray tube with focal spots that is placed below the multi leaf collimator MLC of a r ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health

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