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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. "Modulation of Immune Checkpoints by Self Deliverable RNAi for Adoptive Cell Transfer"

    SBC: ADVANCED RNA TECHNOLOGIES LLC            Topic: 102

    Two of the most promising approaches to cancer immunotherapy are immune checkpoint blockade by monoclonal antibodies and the adoptive transfer of immune cells The recent successes in treating melanoma with anti PD and anti CTLA antibodies as well as the extremely successful application of T cells engineered to express the CAR receptor targeting CD to treat B cell lymphomas initiated a waterfal ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. 3D living neural networks

    SBC: MEADOWLARK OPTICS, INC.            Topic: 101

    DESCRIPTION provided by applicant Mental disease including schizophrenia depression and autism spectrum disorders are still poorly understood although it is clear that they mostly represent cortical disorders The cortex is the primary site of higher mental functions yet despite extensive research there is still no unified theory of how the cortex works This is partly due to the fact that ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. A Biomimetic Prehensile Digit for Upper-Limb Amputees

    SBC: Invisible Hand Enterprises, LLC            Topic: NICHD

    DESCRIPTION provided by applicant Prostheses reduce the incidence of contralateral overuse syndrome in upper limb amputees by encouraging balanced bimanual limb usage Benefits include reduced pain and muscular atrophy increased productivity and self reliance improved self image a sense of well being and increased social acceptance Body powered prostheses are used extensively in the Uni ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  4. A Holographic Module for Multiphoton Microscopes in Neuroscience

    SBC: Boulder Nonlinear Systems, Inc.            Topic: 101

    DESCRIPTION provided by applicant Improving our understanding of the functional circuitry of the brain has important and manifold implications for our understanding of mental health as well as fields like consciousness and computing In the last decade optical techniques have arisen that allow both recording and control of targeted neurons for brain mapping and many of the best of these tech ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  5. A next generation spatial light modulator for mapping of neural networks

    SBC: Boulder Nonlinear Systems, Inc.            Topic: NIBIB

    Boulder Nonlinear Systems BNS and Prof Edward Boyden s Synthetic Neurobiology Group at the Massachusetts Institute of Technology MIT Media Lab propose to develop a new liquid crystal spatial light modulator SLM capable generating high resolution holograms to overcome the imaging gap that currently divides cellular level optogenetic techniques and whole brain techniques to improve function ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  6. A next-generation spatial light modulator for mapping of neural networks

    SBC: Boulder Nonlinear Systems, Inc.            Topic: NIBIB

    DESCRIPTION provided by applicant Improving our understanding of the fundamental circuitry and dynamics of the brain has far reaching implications for a wide range of fields including mental health computing and the philosophy of the mind To this end one of the critical questions currently facing neuroscientists lies in how brain states and behaviors arise from the activity of ensembles of ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. A Topical Nrf Activator for Oral Mucositis

    SBC: Pathways Bioscience, LLC            Topic: NIDCR

    We propose to develop a topical formulation for preventing or treating oral mucositis Oral mucositis is a common and harmful side effect of radiation therapy and chemotherapy in cancer patients that affects nearly patients in the US annually and can be dose limiting impairing the clinical ability to continue the otherwise needed therapy and that also greatly impacts the patientandapos s ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Addressing Gaps in Pediatric Prescribing Using Scalable and Interoperable Prescription Decision Support

    SBC: RXREVU, INC.            Topic: NICHD

    ABSTRACT Significance Electronic prescribing is now widely adopted by US healthcare systems but clinical functionality of e prescribing falls short in the realm of pediatrics Medication prescribing is intrinsically more complex for pediatric patients due to weight based dosing the lack of widely adopted medication formulation recipes inconsistent off label ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Adjustable Helmet Array for Neonatal Magnetoencephalography

    SBC: QUSPIN INC.            Topic: NICHD

    DESCRIPTION provided by applicant The goal of this project is to develop a very low cost whole head neonatal MEG system that can adapt to the shape and size of the head Clinically there is a longstanding need for a technology that can aid in the diagnosis and prognosis of babies with brain dysfunction due to intrauterine and postnatal central nervous system insults which may result in menta ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Advanced Micropatterned Wound Dressings for Enhanced Epithelialization

    SBC: Sharklet Technologies Inc.            Topic: NIAMS

    Summary Nearly million wounds are treated in U S emergency departments every year Skin wounds such as severe burns large trauma wounds or non healing chronic wounds that are too extensive or complex to close by natural healing are often reconstructed using autologous skin grafts Although autologous skin grafts are currently the gold standard in complex wound repair there are significant ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health

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