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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. An Advanced Lung Organomimetic to Reproduce Human Airway Pathophysiology

    SBC: Pneumax, LLC            Topic: 113

    PROJECT SUMMARYThree of top five causes of death in humans globally are lung relatedchronic obstructive pulmonary diseaseCOPDlower respiratory infections and lung cancers collectively account for over eight million deaths annuallyCurrentlyin preclinical settingstatic cell cultures and animal models are the most widely used systems for mechanistic and translational studiesHowevercritical limitation ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Development of the first wireless near infrared spectroscopy device for preclinical monitoring of cerebral oxygenation

    SBC: Barati Medical, LLC            Topic: 102

    PROJECT SUMMARY Stroke is the fifth largest cause of death and a leading cause of long term disability among adults in the United StatesMore thanneuroprotective and thrombolytic drug candidates for ischemic stroke have failed in clinical trials betweenandraising concerns regarding the efficacy of preclinical studiesOur longterm goal is to improve the value of animal models of ischemic stroke and a ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Developing, Testing and Validating a Wearable Alcohol Biosensor

    SBC: Clinitech, LLC            Topic: 450

    PROJECT SUMMARYThis application for a Phase II SBIR award extends the successful completion of Phase I and represents acollaboration between ClinitechLLC and McLean Hospital Harvard Medical School to continue thedevelopment of a wearable biosensor for detecting alcohol in the interstitial fluid of humansExcessive use ofalcohol accounts for much of the public health burden related to alcohol use di ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Human Milk Concentration Device; Point of Care Technology for Feeding Preterm Infants in Intensive Care

    SBC: MOTHER'S MILK IS BEST, INC.            Topic: NICHD

    Human milk is the best feeding option for preterm infantsHoweverdue to the high nutrient needs of preterm infants in US Neonatal Intensive Care UnitsNICUsthe mother s own milk is most often mixed with bovine milk sourced fortifiers to achieve goal nutrient levelsThe Human Milk ConcentrationHMCdevice concentrates a mother s milk by removing water so that preterm infants can receive adequate nutrien ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. The Point Digit: A ratcheting prosthetic finger using advanced rapid manufacturing technology

    SBC: POINT DESIGNS, LLC            Topic: NICHD

    The Point DigitA Ratcheting Prosthetic Finger UsingAdvanced Rapid Manufacturing Technology Project SummaryAbstract The goal of the proposed project is to develop and commercialize a purely mechanicalratcheting prosthetic fingerthe Point Digitwhichhas an industry leading strength to weight ratiocan be operated unilaterallyone handedoffers anatomical rotation and flexion around the patient s metacar ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. In Vivo Studies of a Novel HDAC Inhibitor for Treating Hemoglobin Disorders

    SBC: CETYA THERAPEUTICS, INC.            Topic: NHLBI

    PROJECT SUMMARY Thehemoglobinopathies are prevalent genetic blood diseases with few treatment optionsIt is estimate thatof the worldandapos s population carries an abnormal hemoglobin gene withinfants born annually with a severe life threatening hemoglobinopathyDrug mediated induction of normalbut developmentally silencedfetal hemoglobinHbFexpression reduces anemia and ameliorates clinical severit ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. A compact, modular two-photon fiber-coupled microscope for in vivo all-optical electrophysiology

    SBC: INTELLIGENT IMAGING INNOVATIONS, INC.            Topic: 101

    Good methods to interrogateand ideally perturbneural systems at the network level have been elusive until recentlyThe advent of biochemical breakthroughsnamely neuronally targeted genetically encoded calcium reporterssuch as GCaMPand light activated channelssuch as channelrhodopsinhave enabledall opticalelectrophysiology where experiments can be conducted that involve simultaneousor closely sequen ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. A wearable high-density MEG system with uOPMs

    SBC: FieldLine Inc.            Topic: 101

    Abstract This Phase I project will focus on developing key elements needed to achieve a wearablehigh densitymagnetoencephalographyMEGdevice based on optically pumped atomic magnetometersOPMsOPM sensors have progressed to be comparable in sensitivity to liquid helium cooled superconducting sensorsSQUIDsbut without the complexity and bulk required by cryogenic coolingAn OPM based MEG provides furthe ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Chronological Sweat Sensor Patch for Real-Time Human Molecular Biomarker Monitoring

    SBC: TDA Research, Inc.            Topic: DHA18003

    Sweat contains biomarkers that give an indication of human cognitive levels. In this SBIR project TDA Research is developing a modular sweat sensor patch that has the capability to not only carry out real-time monitoring of select biomarkers, but also to collect multiple precisely time stamped chronological samples (50-150 Ls each) for off-line analysis in laboratory assays.In Phase I, we demonstr ...

    SBIR Phase II 2019 Department of DefenseDefense Health Program
  10. Immunoassay for early diagnosis of mucormycosis

    SBC: DxDiscovery Incorporated            Topic: NIAID

    Mucormycosis is one of the deadliest of the invasive fungal infectionsMucormycosis occurs most often in patients with hematological malignancies undergoing chemotherapypatients who have received hematopoietic stem cell transplants or patients with diabetes mellitusImproved diagnosis is the most frequently noted unmet need for management of the mucormycosis patientDelays in treatment increase the m ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health

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