Award Data

ABSTRACT Human prion diseases are infectious and invariably fatal neurodegenerative diseases including sporadic Creutzfeldt Jakob disease sCJD the most common form and variant CJD vCJD which is associated to consumption of cattle meat infected by bovine spongiform encephalopathy Currently there is not sensitive objective and non invasive biochemical diagnosis for these diseases and even ...

Native American Cancer Initiatives Inc NACI is a woman owned minority American Indian business with fewer than three full time equivalent employees This for profit company founded in has the mission to provide technical assistance and products to communities patients researchers academicians universities research institutions and professionals on Native Americans cultural iss ...

Project Summary The long term goal of this project is to develop validate and commercialize an assay for improved analysis of C orf a gene on chromosome that is linked to frontotemporal dementia FTD and amyotrophic lateral sclerosis ALS Expansion of a guanine and cytosine rich hexanucleotide repeat GGGGCC in the non coding region of C orf is associated with of familial ALS Th ...

Despite the recent development of novel therapeutic approaches no curative treatment is available for advanced stage melanoma with year survival below Targeted therapy is one of the most promising therapeutic strategies to the treatment of cancer and is a key component of precision medicine which aims to individualize cancer treatment for a given patient IL RA an oncogenic isoform o ...

Boulder Nonlinear Systems BNS and Prof Edward Boyden s Synthetic Neurobiology Group at the Massachusetts Institute of Technology MIT Media Lab propose to develop a new liquid crystal spatial light modulator SLM capable generating high resolution holograms to overcome the imaging gap that currently divides cellular level optogenetic techniques and whole brain techniques to improve function ...

Abstract Peripheral artery disease PAD is a common circulatory problem in which narrowed arteries reduce blood flow to your limbs thereby restricting blood flow During exercise or simply walking there is not sufficient blood flow to keep up with the metabolic demand This causes symptoms most notably leg pain when walking intermittent claudication PAD is also likely to be a sign of more w ...

Project Summary This Phase research project will develop a somatostatin receptor targeted Cu radiopharmaceutical for clinical imaging of neuroendocrine tumors with positron emission tomography PET The short lived Cu radiolabel is readily and repeatedly available for on demand radiopharmaceutical labeling via a compact modular Zn Cu radionuclide generator system developed by Propor ...

ABSTRACT Human prion diseases are infectious and invariably fatal neurodegenerative diseases including sporadic Creutzfeldt Jakob disease sCJD the most common form and variant CJD vCJD which is associated to consumption of cattle meat infected by bovine spongiform encephalopathy Currently there is not sensitive objective and non invasive biochemical diagnosis for these diseases and even ...

PROJECT SUMMARY Healing of chronic wounds is impaired by the presence of necrotic tissue which contains dead cells and debris within second deep partial thickness and third degree full thickness burns eschar and chronic ulcers e g diabetic ulcers The accumulation of non viable tissue in a chronic wound can result in a prolonged inflammatory response and mechanical obstruction of the wo ...

PROJECT SUMMARYLynntech has developed a process to readily identify specific genomic loci in RNA based bacteriophage andvirusesWe have demonstrated direct amplification of specific loci within the dengue genome using convectiveRT PCRcRT PCRThis direct detection of dengue eliminates the need for an independent samplepreparation step in the diagnosis of dengue infectionIn doing sowe transitioned our ...