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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Telehealth Intervention for Improved Blood Pressure Control with Targeted Incentives Using New Technologies and Insights From Behavioral Economics to Increase the Effectiveness of Behavioral Change

    SBC: Wellth Inc.            Topic: NIA

    PROJECT SUMMARY ABSTRACT Hypertension or sustained systolic and diastolic blood pressure BP of and mm Hg or higher is among the most frequently encountered conditions in primary care in the U S The estimated prevalence is among all U S adults and increases with age to affect of seniors Hypertension is also the leading risk factor for cardiovascular disease global mortality ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Isolation and characterization of a primary breast epithelium transforming agent

    SBC: SkinAxis LLC            Topic: 102

    Abstract Breast cancer BC is the most common cancer among women Viruses have long been suspected as a cause of breast cancer However despite the identification of virions in human BC cells and human milk and numerous studies that suggest possible connection between breast cancer and Epstein Barr virus EBV mouse mammary tumor virus MMTV and human papilloma virus HPV the tumorigenic po ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Non invasive risk assessment tool for pediatric heart failure

    SBC: CORAMIR BIOMEDICAL, INC.            Topic: NHLBI

    ABSTRACT Heart Failure HF in pediatric patients is a devastating disease that is difficult to evaluate even with invasive hospital procedures Importantly and unique to the pediatric population approximately of pediatric HF patients spontaneously recover normal heart function within year of diagnosis Unfortunately there is no reliable clinical parameter or biomarker that allows pedia ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. A practical and versatile high resolution D dosimetry system for clinical use

    SBC: HEURIS INC.            Topic: 102

    Quality assurance QA is a critical component of radiation oncology that ensures both effective treatment delivery and patient safety Over the last decade dQA is now particularly important asramatic innovations in treatment delivery technologiesy have led to increasingly sophisticated and complex treatments that are difficult to adequately verify with conventional dosimetric verification system ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. An Improved Method of Delivering a Sclerosing Agent for the Treatment of a Malignant Pleural Effusion

    SBC: TDL Innovations, LLC            Topic: 102

    Project Summary We are developing an improved clinical method to treat patients with malignant pleural effusions A pleural effusion is an abnormal build up of fluid in the pleural cavity the fluid space that surrounds the lungs These malignant pleural effusions MPE occur in patients in the US each year affecting between to of all cancer patients Management of a MPE is p ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Development of Antimicrobial Peptides to Target Gram negative Pathogens

    SBC: Aurora Oncology, Inc.            Topic: NIAID

    The dramatic and ever increasing emergence of medically relevant strains of bacteria resistant to traditional antibiotics is now a major human health issue Antibiotic resistance has arisen due to the extensive clinical use of classical antibiotics We have now seen the development of so called Superbugs that are resistant to most or all of the available antibiotics The Infectious Diseases Soci ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Addressing Gaps in Pediatric Prescribing Using Scalable and Interoperable Prescription Decision Support

    SBC: RXREVU, INC.            Topic: NICHD

    ABSTRACT Significance Electronic prescribing is now widely adopted by US healthcare systems but clinical functionality of e prescribing falls short in the realm of pediatrics Medication prescribing is intrinsically more complex for pediatric patients due to weight based dosing the lack of widely adopted medication formulation recipes inconsistent off label ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Method for High Throughput Assembly of Long DNA Fragments in vitro

    SBC: PHARMASEQ, INC            Topic: 200

    SUMMARY The main project goal is to develop principles and demonstrate the feasibility of a fast in vitro method that will increase the length of synthetic double stranded DNA from its current limit of about kb to kb This in turn will facilitate the ability to more rapidly create artificial genes and chromosomes and thus become an important tool in synthetic biology The proposed approac ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Small Molecule Therapy for the Treatment of Heart Failure

    SBC: SUMOCOR LLC            Topic: NHLBI

    ABSTRACT The incidence of heart failure HF continues to increase in the United States despite significant advances in pharmacological therapies and novel devices There is an acute need for novel treatment strategies for heart failure A key abnormality in HF is defective handling of calcium that has been partially related to abnormal sarcoplasmic reticulum SR function in cardiac myocytes Red ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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