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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Ice Free Vitrification and nanowarming of large cartilage samples for transplantation

    SBC: TISSUE TESTING TECHNOLOGIES LLC            Topic: NIAMS

    Resurfacing of articular cartilage with cold stored osteochondral allografts is employed clinically for repair of trauma and osteoarthritis induced articular cartilage surface damage Chondrocyte viability of transplanted articular cartilage is accepted as one of the determinants of outcome following osteochondral allograft transplantation We have previously developed an ice free vitrification me ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. A Novel Millimeter wave mmw DNP EPR Front end Compatible with Versatile High field NMR Probes

    SBC: DOTY SCIENTIFIC, INC.            Topic: NIA

    A Novel Millimeter wave mmw DNP EPR Front end Compatible with Versatile High field NMR Probes Abstract There has been explosive growth in interest in Dynamic Nuclear Polarization DNP with Magic Angle Spinning MAS over the past five years because it has demonstrated S N gains exceeding two orders of magnitude at K compared to conventional MAS NMR and non spinning NMR of biological macro ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Non invasive risk assessment tool for pediatric heart failure

    SBC: CORAMIR BIOMEDICAL, INC.            Topic: NHLBI

    ABSTRACT Heart Failure HF in pediatric patients is a devastating disease that is difficult to evaluate even with invasive hospital procedures Importantly and unique to the pediatric population approximately of pediatric HF patients spontaneously recover normal heart function within year of diagnosis Unfortunately there is no reliable clinical parameter or biomarker that allows pedia ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Evaluation of a Connexin based Peptide for the Treatment of Age Related Macular Degeneration

    SBC: FirstString Research, Inc            Topic: N

    PROJECT SUMMARY ABSTRACT FirstString Research has identified a novel peptide that shows therapeutic potential in the treatment of age related macular degeneration AMD This Phase I SBIR will assess both the feasibility and mechanism of action involved in the topical delivery of a synthetic connexin based peptide aCT for the treatment of AMD AMD is a retinal disease in patients who progress ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. A Novel Scaffold to Promote Skin Regeneration

    SBC: FirstString Research, Inc            Topic: NIAMS

    PROJECT SUMMARY Dermal scarring affects more than million people worldwide annually over million people are injured in motor vehicle accidents over million patients are severely burned and thousands of warriors are wounded in military blasts In severe burns more than of patients develop hypertrophic scar contraction which leads to hypertrophic scar contractures HSc HSc a ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Development of Antimicrobial Peptides to Target Gram negative Pathogens

    SBC: Aurora Oncology, Inc.            Topic: NIAID

    The dramatic and ever increasing emergence of medically relevant strains of bacteria resistant to traditional antibiotics is now a major human health issue Antibiotic resistance has arisen due to the extensive clinical use of classical antibiotics We have now seen the development of so called Superbugs that are resistant to most or all of the available antibiotics The Infectious Diseases Soci ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Addressing Gaps in Pediatric Prescribing Using Scalable and Interoperable Prescription Decision Support

    SBC: RXREVU, INC.            Topic: NICHD

    ABSTRACT Significance Electronic prescribing is now widely adopted by US healthcare systems but clinical functionality of e prescribing falls short in the realm of pediatrics Medication prescribing is intrinsically more complex for pediatric patients due to weight based dosing the lack of widely adopted medication formulation recipes inconsistent off label ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Matrix free Laser Desorption and Ionization Substrates for Mass Spectroscopy

    SBC: InRedox LLC            Topic: 400

    Project Summary This multi phase SBIR project targets an important problem in life science increasing resolution and throughput of mass spectroscopy MS using inexpensive nanostructures substrates for matrix free laser desorption and ionization LDI Soft ionization techniques for MS such matrix assisted LDI MALDI have become among the most important tools in applications from proteomics ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. SBIR Phase I Protein A membrane columns for rapid protein purification

    SBC: Purilogics, LLC            Topic: 400

    Project Summary This SBIR Phase I project is significant because it addresses a critical need for products that increase research productivity during drug discovery and development Improving research productivity plays a key role in translating biologics from research labs to approved medications efficiently and economically Product purification often limits the productivity and time delays in ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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