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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Topical Eyedrop Therapy for Keratoconus

    SBC: IVEENA DELIVERY SYSTEMS, LLC            Topic: N

    Project Summary Keratoconus KCN is a progressive disorder associated with structural changes in corneal collagen organization that leads to corneal thinning and ruptures in Bowman s layer and or Descemet s membrane As the disease progresses it leads to irregular astigmatism progressive myopia and subsequently poor visual acuity Treatment options are surprisingly limited with no oral or topi ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. D peptide inhibitors of SIRPα anti phagocytic signaling

    SBC: NAVIGEN, INC.            Topic: 100

    PROJECT SUMMARY The cell surface CD protein is a marker of self and signals through its receptor signal regulatory protein SIRP expressed by macrophages to transmit an anti phagocytic donandapos t eat me signal CD is expressed by virtually all cell types is overexpressed by cancer cells as a mechanism to avoid immune surveillance and phagocytosis and is a negative prognostic f ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Non invasive risk assessment tool for pediatric heart failure

    SBC: CORAMIR BIOMEDICAL, INC.            Topic: NHLBI

    ABSTRACT Heart Failure HF in pediatric patients is a devastating disease that is difficult to evaluate even with invasive hospital procedures Importantly and unique to the pediatric population approximately of pediatric HF patients spontaneously recover normal heart function within year of diagnosis Unfortunately there is no reliable clinical parameter or biomarker that allows pedia ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Development of Antimicrobial Peptides to Target Gram negative Pathogens

    SBC: Aurora Oncology, Inc.            Topic: NIAID

    The dramatic and ever increasing emergence of medically relevant strains of bacteria resistant to traditional antibiotics is now a major human health issue Antibiotic resistance has arisen due to the extensive clinical use of classical antibiotics We have now seen the development of so called Superbugs that are resistant to most or all of the available antibiotics The Infectious Diseases Soci ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Novel iobio analysis supporting genome scale data quality control

    SBC: Frameshift Labs, Inc.            Topic: 172

    Project Summary Identifying disease causing genetic variants is a complex process often involving the analysis of the genomes of affected patients and their immediate families When employing these state of the art techniques however the number of patients receiving a successful diagnosis is still only at approximately One reason for this low diagnosis rate is the presence of localised dat ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Addressing Gaps in Pediatric Prescribing Using Scalable and Interoperable Prescription Decision Support

    SBC: RXREVU, INC.            Topic: NICHD

    ABSTRACT Significance Electronic prescribing is now widely adopted by US healthcare systems but clinical functionality of e prescribing falls short in the realm of pediatrics Medication prescribing is intrinsically more complex for pediatric patients due to weight based dosing the lack of widely adopted medication formulation recipes inconsistent off label ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Matrix free Laser Desorption and Ionization Substrates for Mass Spectroscopy

    SBC: InRedox LLC            Topic: 400

    Project Summary This multi phase SBIR project targets an important problem in life science increasing resolution and throughput of mass spectroscopy MS using inexpensive nanostructures substrates for matrix free laser desorption and ionization LDI Soft ionization techniques for MS such matrix assisted LDI MALDI have become among the most important tools in applications from proteomics ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Point of Care Prognostic Tool for Sepsis

    SBC: Mbio Diagnostics, Inc.            Topic: 200

    Sepsis is a devastating cause of morbidity and mortality in intensive care units ICUs with estimates of U S incidence ranging from to million cases annually The heterogeneity of clinical presentation etiology patient history severity etc creates a major challenge for patient management and has significantly complicated development of new therapies almost all of which have f ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Personal Mercury Monitor for Exposure Measurements

    SBC: 2B TECHNOLOGIES, INC.            Topic: 113

    Personal Mercury Monitor for Exposure Measurements Project Summary Abstract Workers in the oil and natural gas industry are vulnerable to exposure to toxic mercury Hg vapor as a result of routine inspection and maintenance of equipment such as compressors and other process equipment that concentrate species of low volatility over time Exposure of workers to mercury is of concern in many other ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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