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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. A Novel Strategy to Identify Substances that Improve Mitochnodrial Fitness

    SBC: CYTEGEN CORP            Topic: NIA

    Project Summary Abstract Mitochondrial dysfunction causes mitochondrial diseases and is tightly linked to aging and neurodegenerative disorders such as Parkinsonandapos s and Alzheimerandapos s Recent discoveries support that mitochondrial dysfunction can be overcome to treat age related decline Cytegenandapos s hypothesis is that exercise induces the secretion of blood borne proteins that act ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Development of a Photoacoustic Quantitative Ultrasound PAQUS device for clinical use

    SBC: IF, LLC            Topic: NIAMS

    Title Development of a Photoacoustic Quantitative Ultrasound PAQUS device for clinical use Abstract The objective of this program is to develop a highly innovative bone assessment device by combining our recently invented photoacoustic physio chemical analysis PAPCA technique with more established quantitative ultrasound QUA techniques After a clinic ready Photoacoustic Quantitative Ultra ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Non invasive risk assessment tool for pediatric heart failure

    SBC: CORAMIR BIOMEDICAL, INC.            Topic: NHLBI

    ABSTRACT Heart Failure HF in pediatric patients is a devastating disease that is difficult to evaluate even with invasive hospital procedures Importantly and unique to the pediatric population approximately of pediatric HF patients spontaneously recover normal heart function within year of diagnosis Unfortunately there is no reliable clinical parameter or biomarker that allows pedia ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Development of Antimicrobial Peptides to Target Gram negative Pathogens

    SBC: Aurora Oncology, Inc.            Topic: NIAID

    The dramatic and ever increasing emergence of medically relevant strains of bacteria resistant to traditional antibiotics is now a major human health issue Antibiotic resistance has arisen due to the extensive clinical use of classical antibiotics We have now seen the development of so called Superbugs that are resistant to most or all of the available antibiotics The Infectious Diseases Soci ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Addressing Gaps in Pediatric Prescribing Using Scalable and Interoperable Prescription Decision Support

    SBC: RXREVU, INC.            Topic: NICHD

    ABSTRACT Significance Electronic prescribing is now widely adopted by US healthcare systems but clinical functionality of e prescribing falls short in the realm of pediatrics Medication prescribing is intrinsically more complex for pediatric patients due to weight based dosing the lack of widely adopted medication formulation recipes inconsistent off label ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Novel Continuous Esophageal Pressure Monitoring Catheter with Feeding Tube

    SBC: RUSH RIVER RESEARCH CORPORATION            Topic: NICHD

    PROJECT SUMMARY ABSTRACT Over US adults and children are on mechanical ventilators in intensive care units each year While major advancements in ventilator devices have improved outcomes for critically ill patients current ventilator practice is predominately based on measurements of airway pressure The more relevant pressure particularly to determine if mechanical ventilation is causi ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. A cloud based software platform to enhance reproducibility collaboration and translation of stem cell research

    SBC: Cellara, LLC            Topic: 400

    Project Summary Stem cell research has shown great potential to help treat or even cure a wide array of health conditions including cardiovascular and neurological disease cancer and diabetes This field is now beginning to move rapidly from the re search stage to clinical translation and commercial applications However it has been widely recognized that stem cell scientists have difficulty ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Matrix free Laser Desorption and Ionization Substrates for Mass Spectroscopy

    SBC: InRedox LLC            Topic: 400

    Project Summary This multi phase SBIR project targets an important problem in life science increasing resolution and throughput of mass spectroscopy MS using inexpensive nanostructures substrates for matrix free laser desorption and ionization LDI Soft ionization techniques for MS such matrix assisted LDI MALDI have become among the most important tools in applications from proteomics ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Point of Care Prognostic Tool for Sepsis

    SBC: Mbio Diagnostics, Inc.            Topic: 200

    Sepsis is a devastating cause of morbidity and mortality in intensive care units ICUs with estimates of U S incidence ranging from to million cases annually The heterogeneity of clinical presentation etiology patient history severity etc creates a major challenge for patient management and has significantly complicated development of new therapies almost all of which have f ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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