Award Data

DESCRIPTION provided by applicant Development of radiological nuclear medical countermeasures to treat Acute Radiation Syndrome ARS is a high priority research area for NIAID Bone marrow is one of the most sensitive tissues to radiation damage and impaired hematopoiesis is one of the first clinical signs of excessive radiation exposure often resulting i death Granulocyte colony stimulating ...

CEO Praxis, Inc. is proposing to research the feasibility of developing an approach for small and medium sized manufacturing enterprises to implement the key steps needed to 1) evaluate market opportunities and trends, 2) build interfirm relationships with customers and/or collaborators, 3) develop marketing strategies, and 4) execute effective marketing tactics. The research will be completed by ...

Studies have found Cryptosporidium parvum (C. parvum) oocysts in 65-97% of surface water tested inthe United States. The current Surface Water Treatment Rule does not include analysis for C. parvum.However, the increased incidence of outbreaks involving Cryptosporidiosis have instigated aninvestigation into whether or not testing should be included in the Enhanced Surface Water TreatmentRule. Th ...

Phase I research will demonstrate the feasibility of the proposed Rural Distributed ManufacturingSystem (RDMS). The RDMS concept has the potential to bring new jobs to rural states.The RDMS is a disciplined framework that ties together technologies and operating techniques todistribute manufacturing work over a region. The RDMS will integrate dispersed laborresources, enabling the manufacture of ...

Phase I research will demonstrate the feasibility of a new cracked grain monitor that can mount directlyonto a combine to detect breakage in a variety of clean grains while they are being harvested. Whenintegrated into a closed-loop threshing control system, this sensor will greatly improve the quality ofgrain by providing real-time monitoring and control of cracked grain percentages, will reduce ...

DESCRIPTION (provided by applicant): Invasive candidiasis (IC) is one of the most serious threats to patients in a critical setting. With as many as 60,000 cases per year in the U.S., the total cost associated with IC in the U.S. may be as high as 2-4 billion/year. One of the most critical factors influencing patient outcome is early diagnosis. The goal of this project is a rapi and inexpensive i ...

DESCRIPTION: New therapeutic agents are urgently needed for the treatment of sickle cell disease (SCD), the world's most common genetic disease. Our long-term goal is to develop a drug for use in children that prevents the inexorable progression of SCD. SCD affects approximately 100,000 people in the United States and millions worldwide. It kills more children in Africa than HIV, but while HI ...

DESCRIPTION (provided by applicant): Breast cancer is expected to cause 39,510 deaths of American women in 2012 and 450,000 deaths globally. Once breast cancer has spread, it is essentially incurable. A critical barrier to treating advanced breast cancer is the lack of cancer-specific drugs that are effective in a large percentage of cancer patients and have low toxicity. Sixone Solutions, LLC pro ...

DESCRIPTION (provided by applicant): Nonlinear optical microscopy techniques (such as two-photon florescence) are being used to acquire volumetric (i.e. three dimensional) images that probe several hundred microns into scattering tissue. These techniques are being combined with fast acquisition schemes to allow imaging of live, moving specimens at high NA. This combination allows for high-resoluti ...

DESCRIPTION (provided by applicant): The long-term goal of this proposal is to develop more effective therapies for cancer, specifically pancreatic cancer. The specific focus of this proposal is to improve upon the anti-cancer activity of the drug gemcytabine. This will be accomplished by synthesizing novel conjugates of gemcytabine in a form that enables increased pathways for uptake into cancer ...