Award Data

DESCRIPTION (provided by applicant): Calista Therapeutics has discovered a first-in-class, proprietary PDZ1-2 lead drug, AT010, that is being optimized and developed as an inhaled daily therapy for cystic fibrosis (CF). CF is a deadly inherited genetic disorder that disrupts chloride channel function, resulting in the buildup of sticky mucus in patient's lungs and other organs.CF patients hav ...

CES in cooperation with QinetiQ-NA successfully demonstrated a rapid deployment 18 thick, 24 wide x 24 tall, 400 pound applique support system that easily surpassed its Phase 1 performance requirement of 3-5 G by as much as 300%; an unprecedented 10 G (4140 pounds) of sustained static loading. CES, working with QinetiQ-NA proposes to advance and refine the technology and design during Phase II ...

This Small Business Technology Transfer (STTR) Phase I effort will demonstrate the feasibility of an innovative tungsten carbide (WC) metal matrix composite for use as a non-carcinogenic penetrator for armor piercing (AP) munitions for small arms. The objectives of this effort are to: 1) Mechanically compact the WC and binder powders, 2) Sinter the compacted powders into a fully dense composite, 3 ...

The proposed Phase I work will deliver a noninvasive, small, portable functional pulse oximeter based finger prototype device capable of heartbeat-to-heartbeat estimation of: 1) closeness to hemodynamic decompensation of injured warfighters for the purpose of triage; 2) effectiveness of fluid resuscitation in a bleeding or a potentially bleeding patient; and, 3) fluid volume required by a bleedin ...

Sporian proposes to develop a wireless sensor suite for rotorcraft Generator Control Unit (GCU) and Main Power Relay (MPR) health monitoring. This sensor suite will monitor the GCU for changes in component characteristics (e.g. resistance of relay contacts), temperature, vibration extremes, voltage surges, and other factors that will indicate the unit is close to the end of its serviceably life. T ...

DESCRIPTION (provided by applicant): Invasive candidiasis (IC) is one of the most serious threats to patients in a critical setting. With as many as 60,000 cases per year in the U.S., the total cost associated with IC in the U.S. may be as high as 2-4 billion/year. One of the most critical factors influencing patient outcome is early diagnosis. The goal of this project is a rapi and inexpensive i ...

DESCRIPTION (provided by applicant): Chronic musculoskeletal pain creates a significant public health burden. Veterans are disproportionately affected by chronic musculoskeletal pain, and in particular, chronic low back pain (CLBP). The frequency and extent of co-occurrence of pain and PTSD, pain and Traumatic Brain Injury (TBI), and all three conditions (Post-deployment Multi-symptom Disorder (PM ...

In this Phase I STTR proposal we will determine the ruggedness of the genetic immunization technique in the production of duck egg derived immunoglobulin; specifically the natural F(ab")2 analog, IgY^Fc. We have already demonstrated that potently neutralizing duck egg antibodies generated with an early candidate Andes virus DNA vaccine, delivered via intramuscular electroporation, can protect afte ...

In this Phase II STTR proposal we will demonstrate the scalability and ruggedness of the production system necessary for the commercialization of the goose egg-derived immunoglobulin product that is a countermeasure to the lethal (40 %) Hantavirus Pulmonary Syndrome caused by Andes Virus (ANDV). A major objective will be creating a Quality System (QS) around the global process that aligns it with ...

Reliable knowledge of soil moisture is required for numerous Army and civilian applications including mobility assessments, flood forecasting, agricultural management, erosion mitigation, and control of vector-borne diseases. Soil moisture cannot be measured at the resolution that is required for these purposes (approx. 30 m grid cells), so a simple but accurate downscaling tool is needed. The p ...