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DESCRIPTION provided by applicant Avatar is developing HIV vaccine immunogens based on dityrosine DT crosslinking of soluble native Env gp trimers Several of the most potent broadly neutralizing Abs andquot bnAbsandquot preferentially bind native Env trimers and a trimeric immunogen thus would both present a wide range of key neutralizing epitopes and simultaneously focus immune responses away fro ...

DESCRIPTION provided by applicant Rapid Portable HIV Detection and Monitoring System The long term objectives of this project are Develop a prototype of a rapid portable instrument for detecting and measuring the amount of Human Immunodeficiency Viruses HIVandapos s in samples of patient blood particularly in low resource settings Carry out a pilot study to establish the effectivene ...

DESCRIPTION provided by applicant Approach specific Multi GPU Multi tool High realism Neurosurgery Simulation Surgical treatment of neurological diseases is complicated and requires advanced training However compressed internship schedules in hospitals creates a challenge to young surgeons to master techniques needed for such complex procedures Surgical simulators are powerful tools to p ...

DESCRIPTION provided by applicant Significant obstacles exist in care delivery that prevents meaningful utilization of mental health services by consumers who experience health disparities Specifically individuals facing isolation due to linguistic literacy or cultural bariers often face challenges in procuring mental health care These challenges are in part due to the medical and mental systemsan ...

DESCRIPTION provided by applicant Development of radiological nuclear medical countermeasures to treat Acute Radiation Syndrome ARS is a high priority research area for NIAID Bone marrow is one of the most sensitive tissues to radiation damage and impaired hematopoiesis is one of the first clinical signs of excessive radiation exposure often resulting i death Granulocyte colony stimulating ...

A spacecraft thermal control system must keep the vehicle, avionics and atmosphere (if crewed) within a defined temperature range. Since water is non-toxic and good for heat transport, it is typically used as the coolant that circulates within the crew cabin boundary. This loop then interfaces with another low freeze point fluid, such as ammonia, for transport of heat to a radiator where the tempe ...

NASA is keen on advancing technologies for lightweight composite cryotanks for heavy lift vehicles for future NASA missions. Two primary challenges must be overcome to enable the use of composite tanks for these new classes of heavy launchers. One is to develop novel, microcrack-resistant, polymer matrix composite materials that will enable the manufacture of 5 to 10 meter diameter composite tanks ...

The objective of this proposal is to demonstrate a set of methods for automatically extracting metadata from diverse data sets to serve as a common vocabulary by which data can easily be queried, retrieved and combined for visualization in a geobrowser. We propose extracting keyword tags from both structured and unstructured data sets by applying natural language processing (NLP) to metadata and u ...

The protocols needed to coordinate the activities of distributed components, such as consensus algorithms, are notoriously difficult to design, implement, and verify. Abstraction is the only way to gain intellectual control over this complex problem; so ATC-NY and Cornell University have developed Event Logic, a high-level model for describing and reasoning about distributed systems, and EventML, ...

TDA Research, Inc. is developing a compact, low power, Next-Generation Exercise Device (NGRED) that can generate any force between 5 and 600 lbf. We use a closed loop control system and a servo motor to smoothly and accurately simulate the gravitational and inertial loads of lifting a weight on earth. However, because the system uses a computer-controlled motor, the load can be varied independentl ...