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DESCRIPTION provided by applicant There are roughly new cases of metastatic cancer to the skeleton in the U S each year andquot Bone seekingandquot radiopharmaceuticals are used for bone pain palliation and have shown promise for treating bone metastases They typically combine a radioactive metal such as samarium with a chelant The chelant part of the molecule is taken up by gr ...

DESCRIPTION provided by applicant MALDI tissue imaging when enabled by Nanoparticulate NP Matrix implantation is maturing into a useful preclinical tool for biomarker and drug discovery in our laboratory and at NIDA IRP Quantitatively reproducible images from serial coronal sections suggest that relative quantitation is now possible in rodent models of disease and injury Nanoparticulate ...

DESCRIPTION provided by applicant Development of radiological nuclear medical countermeasures to treat Acute Radiation Syndrome ARS is a high priority research area for NIAID Bone marrow is one of the most sensitive tissues to radiation damage and impaired hematopoiesis is one of the first clinical signs of excessive radiation exposure often resulting i death Granulocyte colony stimulating ...

DESCRIPTION provided by applicant Persistent respiratory methicillin resistant Staphylococcus aureus MRSA infections have become increasingly common in cystic fibrosis CF patients with a prevalence of almost in CF patients in the US This is concerning as MRSA positivity is associated with a faster decline of lung function and a years shorter median life expectancy compared to CF p ...

The integrated sensor suites of the Apache Longbow and Guardian are capable of the most advanced enemy and friendly unit classification for ground support operations to date. Satellite-synched tracking maps, enemy weapons classification, and precision targeting will all be realized in the latest upgrades to the AH-64 platform. Smart rounds are set to utilize this integrated sensor suite to deploy ...

The main goal of the Phase II program is to build and test an operational prototype compressive sensing (CS) camera capable of high-speed change detection. Based on the algorithmic development, hardware modeling and simulation achievements of Phase I, we have defined a real-time CS framework that will be implemented in Phase II in an operational prototype. This framework, similar to Phase I, begin ...

We propose to leverage the expertise of Applied Nanotech, Inc. (ANI) in building highly sensitive, selective, portable and versatile GC/DMS instruments, to create a system to uniquely identify pollen species in complex mixtures based on their VOC profile. This project will determine which VOCs shall be collected and how many pollen grains are needed in order to increase the confidence of accuratel ...

In this Phase II STTR proposal we will demonstrate the scalability and ruggedness of the production system necessary for the commercialization of the goose egg-derived immunoglobulin product that is a countermeasure to the lethal (40 %) Hantavirus Pulmonary Syndrome caused by Andes Virus (ANDV). A major objective will be creating a Quality System (QS) around the global process that aligns it with ...

Knowledge Based Systems, Inc. (KBSI) proposes to design, build, and validate a semantic framework for Collaborative Analysis and Knowledge Exploration (CAKE). CAKE provides the following innovative capabilities (1) Automated ontology-driven semantic tagging of multi-source text and image data; (2) Semantic information fusion and collaborative information analysis for enhanced situational awarenes ...

Methanol crossover of commercial Nafion membranes is a major issue that results in lowering of the efficiency of direct methanol fuel cells (DMFCs). A biomimetic approach for the membrane design using either proton conducting nanochannels and/or nanothin barrier layer can produce DMFC membranes with highly selective and fast proton transfer. In the Phase I project, Lynntech demonstrated the feasib ...