Award Data

DESCRIPTION provided by applicant The exponential increase of diabetics and the elderly in the U S has more than tripled the number of cataract surgeries performed in just two decades As many as half of these surgeries will lead to posterior capsular opacification PCO which requires follow up Nd YAG laser capsulotomy surgery Without this additional procedure patients can suffer permanent ...

DESCRIPTION provided by applicant The nontuberculous Mycobacteria NTM are a growing public health concern as the number of opportunistic infections increases Although not a reportable disease there is growing epidemiologic evidence to suggest that NTM cause more infections today in the United States than Mycobacterium tuberculosis Mtb yet unlike Mtb there are few dedicated antimicrobial ...

DESCRIPTION provided by applicant Neurodegenerative diseases such as Alzheimer and other dementias present significant societal and economic burden The number of patients suffering from these disorders grows rapidly owing to the aging of the world population Alzheimerandapos s Association projects that the number of Americans living with Alzheimerandapos s disease AD will increase from ...

DESCRIPTION provided by applicant Advanced imaging technologies such as Positron Emission Tomography PET and Magnetic Resonance Imaging MR have led to remarkable improvement in our knowledge of brain metabolism function and biochemistry And yet our understanding of most neurological disorders is at best rudimentary Etiology of such common diseases as drug and alcohol addiction schiz ...

DESCRIPTION provided by applicant The goal of this Phase I Phase II fast track application is to develop and evaluate a simulation based product for training students and clinicians to develop the skills necessary to effectively apply Cognitive Behavioral Treatment CBT with patients with substance use disorders SUDs CBT is one of the most common and effective treatments for SUDs however ...

DESCRIPTION provided by applicant As new genetic analysis methods are developed rising emphasis is being placed on high quality sample preparation and the ability to obtain large quantities of high molecular weight and high purity DNA In DNA sequencing rd generation technologies offer long read lengths up to kb and require high quality isolated DNA In gene therapy and DNA vaccines high ...

DESCRIPTION provided by applicant Wireless Enhanced Myoelectric Control to Improve Upper Extremity Amputee Ability ABSTRACT The overall goal of our research program is to enable upper extremity amputees to be productive and independent For these individuals one of the most promising developments in the past decade has been the introduction of fully dexterous terminal devices However an effe ...

DESCRIPTION provided by applicant Phase and Phase clinical trials of a new class of redox active pharmaceutical are proposed in high grade glioma WHO grade III and IV This project will test a compound that crosses the blood brain barrier and which prevents hippocampal stem cell loss and white matter degradation following radiation therapy RT The compound also inhibits tumor regrowth f ...

DESCRIPTION provided by applicant Personal Exposure Monitoring of Air Pollutants as an Educational Tool in the GO Treks project launched by the Phase I grant students at schools throughout the U S used personal monitors to measure the air pollutants black carbon and ozone along treks of their own design The treks were uploaded to blogs in the GO website where they were displ ...

DESCRIPTION provided by applicant Sample preparation frequently presents a bottleneck for clinical molecular biology workflows and diagnostic tests Whereas there are many molecular detection modalities there are only a handful of automated sample preparation workflow strategies Existing instruments that are built around these sample preparation strategies and chemistries range in cost from $ ...