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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Scientific Merit and Feasibility of Fructokinase Inhibition for Obesity

    SBC: COLORADO RESEARCH PARTNERS LLC            Topic: 300

    Our goal is to develop a firstin class therapeutic agent that directly blocks the metabolism of fructosea key component in sugarIntake of sugarsucroseand high fructose corn syrupHFCSinduces metabolic syndrome and diabetes in laboratory animals and are strongly associated with obesity and diabetes in humansBoth sucrose and HFCS contain fructosewhich stimulates food intake by inducing leptin resista ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Evidence-Based Pain Intervention for Veterans: Leveraging Mobile and Social Media

    SBC: Pro-Change Behavior Systems, Inc.            Topic: NCCIH

    Chronic musculoskeletal pain creates a significant public health burden, and Veterans are disproportionately affected. The frequency and extent of co-occurrence of pain and PTSD, pain and Traumatic Brain Injury (TBI), all three conditions (Post-deployment Multi-symptom Disorder (PMD), and other multi-symptom syndromes can complicate and reduce the effectiveness of pain treatment. Furthermore, the ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Novel Bone-Targeting Combination Therapy for Osteosarcoma Phase II

    SBC: MBC Pharma, Inc.            Topic: NCI

    Project Summary AbstractThe overall aim of this project is to further develop a novel gemcitabine ibandronate conjugate alone and or as part of a combination therapy for the treatment of osteosarcoma and associated metastasesThe conjugate consists of chemically linked anticancer antimetabolite Gemcitabine and the bone homing bisphosphonate IbandronateThe novel conjugate directly addresses the limi ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Topical proprietary biologic to treat oral mucositis

    SBC: Allander Biotechnologies            Topic: NIDCR

    Summary Oral mucositisa severe oral ulcerationis a common toxic effect of radioor chemoradio therapy and a limiting factor to using the maximum dose of radiation for effective cancer treatmentAt leastand up toof cancer patients treated with standard chemotherapy regimens or upper body radiation develop oral mucositisIntensity modulated RTIMRTlessens chronic side effectsbut not the acute toxicity s ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Targeting the checkpoint regulator VISTA for treatment of inflammatory disease

    SBC: Immunext, Inc.            Topic: R

    ImmuNext has identified and developed a putative lead anti VISTA monoclonal antibodymAbthat we aim to bring to the clinic for the treatment of human autoimmune diseaseVISTA is a member of the highly successful negative checkpoint regulatorNCRfamily of drug targetswhose members have demonstrated proven efficacy in inducing long term remissions in human cancersWe contend that antibodies that suppres ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Open Source System for Audio Processing

    SBC: CREARE LLC            Topic: NIDCD

    This proposal responds to RFA–DC-16-002, in which the NIDCD is seeking to support the development of acoustic signal processing tools that have the potential to accelerate research studies and to facilitate the translation of novel algorithms for hearing aids. Approximately 15% of American adults report some degree of hearing trouble, and 12.7% of Americans aged 12 and over experience bilateral ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Breast Cancer Locator

    SBC: CAIRNSURGICAL, INC.            Topic: 101

    PROJECT SUMMARY ABSTRACTCairnSurgical LLCa Dartmouth spin off companywill optimize and test multi site clinical feasibility of a new image guided intervention devicethe Breast Cancer LocatorBCLin breast conserving surgeryBCStoieliminate wire localizationa moderately effectivesomewhat costly and certainly inconvenient procedure for patients and surgeonsand concomitantly toiireduce positive margin r ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Electrochemical Paper-Based Analytical Devices for Metal Determination

    SBC: Access Sensor Technologies LLC            Topic: NIEHS

    Project Summary The goal of this project is to develop a new sampling and analysis system combining two new technologiesA lightweight ultrasonic sampler will be paired with an electrochemical paper based analytical deviceePADfor measurement of metals in airborne particulate matterPMExposure to particulate matterPMair pollution ranks as theth leading risk factor for human morbidity and mortality wo ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Development of GIFT4: a B cell focused immunotherapy for cancer

    SBC: CELDARA MEDICAL, LLC            Topic: NCI

    Project Summary Our goal is to develop a novel immunotherapy for the treatment of melanomaand potentially a wide array of tumorsAlthough surveillance by the immune system eliminates cancer cells in some instancestumor cells have developed a variety of mechanisms to escape immune recognition often resulting in tumor outgrowthImmune checkpoint inhibitorse gipilimumabnivolumaband pembrolizumaband cel ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Micropatterned surfaces for minimizing pediatric gastrostomy tube complications

    SBC: Sharklet Technologies Inc.            Topic: NICHD

    Summary In a variety of diseases and conditions when oral feeding is impossibleenteral feeding through percutaneous gastrostomyPGis necessary to provide long term nutrition for adult and pediatric patientsIt is estimated that overthousand feeding tubes are placed in pediatric patients in the US annuallyHoweverthese patients frequently experience complications associated with PG tube placementLate ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
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