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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Micro Patterned Intraocular Lens Membrane for Reducing Incidence of PCO

    SBC: Sharklet Technologies Inc.            Topic: N

    DESCRIPTION provided by applicant The exponential increase of diabetics and the elderly in the U S has more than tripled the number of cataract surgeries performed in just two decades As many as half of these surgeries will lead to posterior capsular opacification PCO which requires follow up Nd YAG laser capsulotomy surgery Without this additional procedure patients can suffer permanent ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Single Somatic Cell Epigenetic Models

    SBC: Topogen, Inc            Topic: 200

    DESCRIPTION provided by applicant Epigenetic modifications of DNA and histones are stable encryption systems essential for life For example the importance of DNA methylation is underscored by the consequences of its mis regulation which include defects in tissue homeostasis chronic disease and accelerated aging thus epigenetics broadly impacts human health The information stored in the di ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Selenium-derivatized New Reagents for Nucleic Acid X-ray Crystallography

    SBC: SENA RESEARCH, INC.            Topic: NIEHS

    DESCRIPTION provided by applicant There are growing demands for D structure determination of nucleic acids and their protein complexes for understanding disease molecule level mechanisms and discovering innovative drugs X ray crystallography is one of the most direct and powerful tools for structure determination of these macromolecules and complexes However the crystallization and phase d ...

    STTR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Optimization and Lead Selection of Novel Antimycobacterial Agents

    SBC: CRESTONE, INC.            Topic: 300

    DESCRIPTION provided by applicant The nontuberculous Mycobacteria NTM are a growing public health concern as the number of opportunistic infections increases Although not a reportable disease there is growing epidemiologic evidence to suggest that NTM cause more infections today in the United States than Mycobacterium tuberculosis Mtb yet unlike Mtb there are few dedicated antimicrobial ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  5. BMX-001 as a Therapeutic Agent for Treatment of High-Grade Gliomas

    SBC: BIOMIMETIX JV LLC            Topic: NCI

    DESCRIPTION provided by applicant Phase and Phase clinical trials of a new class of redox active pharmaceutical are proposed in high grade glioma WHO grade III and IV This project will test a compound that crosses the blood brain barrier and which prevents hippocampal stem cell loss and white matter degradation following radiation therapy RT The compound also inhibits tumor regrowth f ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Personal Exposure Monitoring of the Air Pollutants as a K-12 Educational Tool

    SBC: 2B TECHNOLOGIES, INC.            Topic: NIEHS

    DESCRIPTION provided by applicant Personal Exposure Monitoring of Air Pollutants as an Educational Tool in the GO Treks project launched by the Phase I grant students at schools throughout the U S used personal monitors to measure the air pollutants black carbon and ozone along treks of their own design The treks were uploaded to blogs in the GO website where they were displ ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Directed Lineage Immunizations for Eliciting Broadly Neutralizing Antibody

    SBC: GEOVAX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The proposed project Directed Lineage Immunizations for Eliciting Broadly Neutralizing Antibody tests the directed lineage D L approach to HIV vaccination using clade C immunogens With a D L vaccine a series of progressively evolved Env immunogens are used to drive development of a broadly neutralizing antibody bnAb response which is important because ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Nurbits: Playing for Success in Neuroscience (Phase II)

    SBC: IS3D LLC            Topic: 999

    DESCRIPTION provided by applicant The NIH Blueprint for Neuroscience Research identified a need for novel products that engage students in learning neuroscience In Phase I IS D tested the feasibility of Nurbits a videogame in which students apply neuroscience principles to solve puzzles and make music The research team determined that Nurbits was effective in engaging students teachers wer ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Enhanced multiphoton microscopy through spatial light modulation

    SBC: BOULDER NONLINEAR SYSTEMS, INC.            Topic: 102

    DESCRIPTION provided by applicant Nonlinear optical microscopy techniques and particularly multiphoton fluorescence microscopy have become popular tools for visualizing the three dimensional cellular architecture residing hundreds of microns and up to one millimeter deep in living organisms This is particularly valuable in neurobiology where multiphoton techniques have become widely used fo ...

    STTR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Beam Control with a Broadband, High Speed X-Y Variable Light Modulator

    SBC: BOULDER NONLINEAR SYSTEMS, INC.            Topic: 400

    DESCRIPTION provided by applicant The primary proposed objective is to realize a broadband high speed spatial light modulator SLM for microscopy applications Current microscopy techniques frequently employ spatial light modulators to manipulate the phase and amplitude of light illuminating a sample or and or transmitted by a sample The phase and amplitude of light in the microscope illumina ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
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