Award Data

DESCRIPTION provided by applicant Techshot Inc has successfully completed SBIR Phase I and Phase II research demonstrating that magnetically labeled porcine islets of Langerhans can be isolated from contaminating exocrine tissue by flow sorting using a quadrupole magnetic separator andquot Quadrasepandquot designed for that purpose Magnetically sorted islets are superior in morphology and ...

DESCRIPTION provided by applicant Development of radiological nuclear medical countermeasures to treat Acute Radiation Syndrome ARS is a high priority research area for NIAID Bone marrow is one of the most sensitive tissues to radiation damage and impaired hematopoiesis is one of the first clinical signs of excessive radiation exposure often resulting i death Granulocyte colony stimulating ...

The proposed goal of Nevada Nanotech Systems Inc for the Phase I program is to select a practical technological solution and develop a Con-Ops for the problem of detecting U.S. currency via unique vapor signature(s) in confined spaces for three related, though unique, application scenarios (bags, vehicles, and shipping containers). Nevada Nano will document a matrix of technical and operational re ...

For Phase II work, we propose to complete the development of the DICOS compliant ATR algorithm whose feasibility has been demonstrated by results of Phase I work. Important project milestones for the first base year of Phase II are as follows: (1) implementation of the DICOS standard including network protocol, (2) improvement of the proposed ATR algorithm in terms of explosive detection performan ...

The personal protective equipment (PPE) worn by firefighters (turnout Gear, SCBA, helmet, etc.) protects the wearer against burns and hazardous environments. Unfortunately, they work so well that they decrease the firefighter's situational awareness, in particular their ability to notice rapidly increasing temperatures. Although current thermal sensor technologies (generally built in to the Pers ...

Timing and position data from civil GPS receivers have become integral to the operation of many of the Nation's critical infrastructures. Through the Patriot Watch architecture, DHS is coordinating efforts to identify, locate, and attribute domestic GPS interference, maintain a central database for reports of domestic and international interference to civil use of GPS and its augmentations, and n ...

The proposed SkySight Technologies Quick Release Connector will independently detect an unexpected mechanical load on the power distribution line. The compact and lightweight SkySight Quick Release Connector uses existing methods and hardware to integrate into the infrastructure, and no special tools or skills are required. While the connector can be latched by hand without any special tools, it c ...

DESCRIPTION (provided by applicant): Inhibitors of Mycobacterial Protein Tyrosine Phosphatase B (mPTPB) for therapy of tuberculosis Aarden Pharmaceuticals Project Summary/Abstract The need exists for a new, breakthrough therapeutic for tuberculosis (TB). Current treatment regimens with toxic chemotherapeutic drugs are too long, causing poor compliance which results in reduced efficacy and the emer ...

DESCRIPTION (provided by applicant): Invasive candidiasis (IC) is one of the most serious threats to patients in a critical setting. With as many as 60,000 cases per year in the U.S., the total cost associated with IC in the U.S. may be as high as 2-4 billion/year. One of the most critical factors influencing patient outcome is early diagnosis. The goal of this project is a rapi and inexpensive i ...

DESCRIPTION: New therapeutic agents are urgently needed for the treatment of sickle cell disease (SCD), the world's most common genetic disease. Our long-term goal is to develop a drug for use in children that prevents the inexorable progression of SCD. SCD affects approximately 100,000 people in the United States and millions worldwide. It kills more children in Africa than HIV, but while HI ...