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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. AAAPT Technology for Improving Chemotherapy

    SBC: Sci-Engi-Medco Solutions, Inc            Topic: NCI

    DESCRIPTION provided by applicant Dysregulation of apoptosis pathways and loss of Human Beta Defensin hBD are the common tactics adapted by cancer cells to circumvent the effects of chemotherapy Consequently high dose of chemotherapy is required to obtain a clinically relevant therapeutic index which in turn compromises safety and develops resistance to therapy The problem is acute p ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Mindfulness and Acceptance Applied in Colleges Through Web-Based Guided Self-Help

    SBC: CONTEXTUAL CHANGE, LLC            Topic: 213

    DESCRIPTION provided by applicant Nearly half of all college students have a diagnosable mental health problem Blanco et al College counseling centers CCCs are faced with increasing demands for services from Universities students and parents to meet the treatment needs of their students Kay and Schwartz in the context of increasingly severe cases and declining resources ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Noninvasive Total Hemoglobin Monitor

    SBC: Kestrel Labs Inc            Topic: NHLBI

    DESCRIPTION provided by applicant It is a rare event when new and useful medical parameters can be added to the suite of monitoring and diagnostic tests available in a clinical setting Of particular importance is the ability to measure crucial physiological parameters or analyses in a continuous and noninvasive manner evidenced by the importance of noninvasive vital signs monitoring because it ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Experimental Design Software for Translational Gastrointestinal Microbiome Studie

    SBC: WILLIAM D SHANNON CONSULTING LLC            Topic: 300

    DESCRIPTION provided by applicant Design of experiments and test of hypotheses need to be available to research teams to develop and validate taxonomic metagenomic biomarkers in gastrointestinal tract GIT diseases The translational research team needs to design an experiment to test a hypothesis e g microbiota in Crohnandapos s disease is different than in normal controls calculat ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. High throughput RNAi based functional genomics in primary cells and in vivo

    SBC: ADVANCED RNA TECHNOLOGIES LLC            Topic: 172

    DESCRIPTION provided by applicant Completion of the HGP human genome program has opened the andapos Genomic Eraandapos in biomedical research and enables functional genomics analysis of various gene elements The long term goal of the ENCODE Project is to identify and functionally characterize all of the sequence based genomic elements Functional elements that have been studied in ENCODE in ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  6. MIST System for Simultaneous Parallel Intracellular Delivery & Transfection

    SBC: OPENCELL TECHNOLOGIES, INC.            Topic: 400

    DESCRIPTION provided by applicant Alternative nanomaterial and gene transfer solutions are needed to access the potential held in intracellular imaging biopharmaceuticals gene therapy and stem cell research Delivery of small and macromolecules including nucleic acids drug molecules imaging agents peptides antibodies and enzymes into cells is criti ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  7. 3D living neural networks

    SBC: MEADOWLARK OPTICS, INC.            Topic: 101

    DESCRIPTION provided by applicant Mental disease including schizophrenia depression and autism spectrum disorders are still poorly understood although it is clear that they mostly represent cortical disorders The cortex is the primary site of higher mental functions yet despite extensive research there is still no unified theory of how the cortex works This is partly due to the fact that ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. A Biomimetic Prehensile Digit for Upper-Limb Amputees

    SBC: Invisible Hand Enterprises, LLC            Topic: NICHD

    DESCRIPTION provided by applicant Prostheses reduce the incidence of contralateral overuse syndrome in upper limb amputees by encouraging balanced bimanual limb usage Benefits include reduced pain and muscular atrophy increased productivity and self reliance improved self image a sense of well being and increased social acceptance Body powered prostheses are used extensively in the Uni ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Galectin 1: A novel small protein therapy for Duchenne muscular dystrophy

    SBC: STRYKAGEN CORPORATION            Topic: NIAMS

    DESCRIPTION provided by applicant Duchenne Muscular Dystrophy DMD is a fatal muscle disease affecting in every male births DMD results from mutations in the gene encoding the dystrophin a kDa scaffolding protein responsible for providing a mechanical link between the muscle fiber actin cytoskeleton and a transmembrane protein complex called the dystrophin associated glycoprotein ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Direct RT-PCR detection of RNA pathogens in crude samples

    SBC: DNA POLYMERASE TECHNOLOGY, INC.            Topic: 200

    DESCRIPTION provided by applicant The objective of this application is to introduce a novel simplified low cost technology to address the broad need of detecting RNA pathogens directly in crude samples such as blood Traditional RT PCR requires purifying the RNA which increases the cost time and risk of cross contamination We intend to reduce or eliminate the purification step by producin ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
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