Award Data

DESCRIPTION provided by applicant Our goal is to develop a new molecular entity with a novel mechanism of action for targeting and eliminating glioblastoma multiforme GBM high grade glioma a deadly and invasive brain tumor with no effective treatment Of the patients expected to be diagnosed with GBM this year most will succumb within a year There is an urgent demand for an efficac ...

DESCRIPTION provided by applicant The significance of the proposed research is based on the growing demand for healthcare resources to treat and manage prostatic disease particularly benign prostatic hyperplasia BPH and cancer Both the incidence and cost of treatment for BPH and its complications are growing rapidly with the aging U S population prostate cancer is the second leading cau ...

DESCRIPTION provided by applicant This project aims to demonstrate that the evolution of plant biosynthetic pathways can be accelerated and driven to favor the synthesis of ligands which interact with a specific human target protein This is achieved by subjecting mutant plant cells to selection pressures favoring the survival of mutants with the phenotype of interest As an example this appro ...

DESCRIPTION provided by applicant Development of radiological nuclear medical countermeasures to treat Acute Radiation Syndrome ARS is a high priority research area for NIAID Bone marrow is one of the most sensitive tissues to radiation damage and impaired hematopoiesis is one of the first clinical signs of excessive radiation exposure often resulting i death Granulocyte colony stimulating ...

DESCRIPTION provided by applicant Tuberculosis TB disease which results from infection with Mycobacterium tuberculosis Mtb is a leading cause of infectious morbidity and mortality in children andlt years old worldwide In TB endemic regions in which the vast majority of the worldandapos s annual million adult cases of TB disease reside children andlt years old account for ...

There are a significant number of people in the U.S. whose literacy deficits significantly limit opportunities for written self-expression, including individuals with intellectual disabilities. While this population can offer revealing insights given their unique perspectives, self-expression often occurs in the dependent context of transcription by another person, or, perhaps too often, not at al ...

People with intellectual disability depend a great deal on work for their quality of life. Working in community-based jobs can make substantial differences in income, relationships and self-esteem. Technology has improved opportunities for this population to independently express their career interests, but current tools are limited in that they do not support customization to reflect local job an ...

The project goal is to develop and test the feasibility of a self-management system, Goal Guider, consisting of a mobile application and companion web site that allows individuals with intellectual disabilities and autism to effectively manage self-defined goals for everyday living across various personal, educational, and vocational life domains. Users will be able to easily enter goals, work wit ...

This project team is developing a prototype of software for a tablet computer to replace paper tests for teachers to assess the reading fluency of special education students in grade 5 and 6. The technology will provide: scoring and tracking assessments with a stop watch for appropriate timing of questions, upload of data generated from the assessment directly to a database, audio playback capabil ...

The web-based game, Numbershire II, will include modules to support students with or at-risk for disabilities in learning 2nd grade level mathematics, as defined by Common Core State Standards, including fluency with place value ideas, foundations of multiplication, and procedural fluency with multi-digit operations. In the narrative-based game, each student will build and maintain an idyllic Rena ...