Award Data

Traumatic brain injury TBI is an acquired neurological disorder that can cause long lasting disability with limited treatment options Therefore preventative strategies must be emphasized in high risk activities to reduce the individual and societal burden of this pervasive injury Bicycle activities account for of all sports related TBI with over annual injuries in the US In an e ...

Abstract The goal of this project is to utilize cytomegalovirus CMV vectors to develop a therapeutic vaccine against Trypanosoma cruzi the causative agent of Chagas disease Although the most common transmission route is by a triatomine bug vector known as the kissing bug Chagas disease is also spread vertically from mother to child and along blood born routes such as organ transplant and tr ...

Native American Cancer Initiatives Inc NACI is a woman owned minority American Indian business with fewer than three full time equivalent employees This for profit company founded in has the mission to provide technical assistance and products to communities patients researchers academicians universities research institutions and professionals on Native Americans cultural iss ...

Project Summary All cancer patients live with the possibility that their cancer will recur and many patients develop secondary cancers as a result of treatments used for their original cancer This project addresses the problem of drug resistance and disease recurrence in cancer by leveraging unique single nanoparticle techniques to identify rare often hidden drug resistant cells in leukemia ...

Boulder Nonlinear Systems BNS and Prof Edward Boyden s Synthetic Neurobiology Group at the Massachusetts Institute of Technology MIT Media Lab propose to develop a new liquid crystal spatial light modulator SLM capable generating high resolution holograms to overcome the imaging gap that currently divides cellular level optogenetic techniques and whole brain techniques to improve function ...

Project Summary Mobility limitations including gait and balance impairments are common in older adults and are a major cause of falls and reduced quality of life Although laboratory studies show that biofeedback during exercise training can improve motor performance physical therapists do not have access to an overground gait biofeedback system for their patients We will develop Mobility Rehab ...

DESCRIPTIONprovided by applicantChildren who don t master the basics of literacye gphonological awarenessalphabetic awareness and letter writingvocabulary and oral languagein preschool risk failure in acquiring conventional reading skills later in elementary schoolNational Early Literacy PanelStorch et alConsidering that Head StartHSlargely serves children from minority or English learning backgro ...

Project Summary Falls are the leading cause of injurieshospital visitsnursing home admissionsand reduced quality of life for people with neurological disordersAlthough there is consensus that impaired mobility is the basis for most fallsit is very di cult to evaluate these complex abilities outside a laboratory settingBrief clinical examinations do not accurately re ect dailyfunctional mobility in ...

Abstract Stroke is a leading cause of morbidity and mortality in the United States However less than of patients are eligible for the current approved interventions of tissue plasminogen activator or thrombectomy We seek to develop new therapeutics to reduce the extent of damage and functional impairment resulting from ischemic injury to the brain an area of significant unmet medical need ...

DESCRIPTION provided by applicant Bladder cancer is one of the most common forms of cancer in North America Most often bladder cancer presents as superficial disease which is treatable through surgical resection but is also associated with recurrence rates of up to Thus patients must be monitored at regular intervals following resection of the tumor to assess for recurrence This moni ...