Award Data

DESCRIPTION provided by applicant Evaluation of dental tobacco cessation tool in practice based research network This Phase II project will finish development and evaluate QuitAdvisorDDS as a tool for dental providers to advise patients on tobacco cessation The University of Kentucky will evaluate the effectiveness of QuitAdvisorDDS in increasing quit attempts in tobacco using patients The ev ...

DESCRIPTION provided by applicant This application andquot Imaging Software of Functional Connectivity MRI for Alzheimerandapos s Diseaseandquot is written in response to PA andquot Lab to Marketplace Tools for Brain and Behavioral Research SBIR R R andquot Alzheimerandapos s disease AD is the most common form of dementia However developing drugs that effectively slow or alter the course of Alzhei ...

DESCRIPTION provided by applicant There are roughly new cases of metastatic cancer to the skeleton in the U S each year andquot Bone seekingandquot radiopharmaceuticals are used for bone pain palliation and have shown promise for treating bone metastases They typically combine a radioactive metal such as samarium with a chelant The chelant part of the molecule is taken up by gr ...

DESCRIPTION provided by applicant My Coverage Plan Inc MCP proposes to use our newly patented technology to create a commercially viable and nationally replicable suite of software and services for health care providers and other social service agencies that reduces avoidable health disparities and increases provider reimbursements The MCP health IT solution will help providers proactively ...

DESCRIPTION provided by applicant MALDI tissue imaging when enabled by Nanoparticulate NP Matrix implantation is maturing into a useful preclinical tool for biomarker and drug discovery in our laboratory and at NIDA IRP Quantitatively reproducible images from serial coronal sections suggest that relative quantitation is now possible in rodent models of disease and injury Nanoparticulate ...

DESCRIPTION provided by applicant Development of radiological nuclear medical countermeasures to treat Acute Radiation Syndrome ARS is a high priority research area for NIAID Bone marrow is one of the most sensitive tissues to radiation damage and impaired hematopoiesis is one of the first clinical signs of excessive radiation exposure often resulting i death Granulocyte colony stimulating ...

DESCRIPTION provided by applicant Persistent respiratory methicillin resistant Staphylococcus aureus MRSA infections have become increasingly common in cystic fibrosis CF patients with a prevalence of almost in CF patients in the US This is concerning as MRSA positivity is associated with a faster decline of lung function and a years shorter median life expectancy compared to CF p ...

DESCRIPTION (provided by applicant): Invasive candidiasis (IC) is one of the most serious threats to patients in a critical setting. With as many as 60,000 cases per year in the U.S., the total cost associated with IC in the U.S. may be as high as 2-4 billion/year. One of the most critical factors influencing patient outcome is early diagnosis. The goal of this project is a rapi and inexpensive i ...

DESCRIPTION: New therapeutic agents are urgently needed for the treatment of sickle cell disease (SCD), the world's most common genetic disease. Our long-term goal is to develop a drug for use in children that prevents the inexorable progression of SCD. SCD affects approximately 100,000 people in the United States and millions worldwide. It kills more children in Africa than HIV, but while HI ...

DESCRIPTION (provided by applicant): Colorectal cancer is the third leading cause of cancer-related deaths in the U.S. Based on numerous epidemiological studies and recent prospective trials; the use of daily aspirin is associated with a significant reduction in colorectl cancer incidence, deaths and metastatic spread to other organs. However, the chronic use of this drug is limited due to the sid ...