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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. High throughput RNAi based functional genomics in primary cells and in vivo

    SBC: ADVANCED RNA TECHNOLOGIES LLC            Topic: 172

    DESCRIPTION provided by applicant Completion of the HGP human genome program has opened the andapos Genomic Eraandapos in biomedical research and enables functional genomics analysis of various gene elements The long term goal of the ENCODE Project is to identify and functionally characterize all of the sequence based genomic elements Functional elements that have been studied in ENCODE in ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  2. 3D living neural networks

    SBC: MEADOWLARK OPTICS, INC.            Topic: 101

    DESCRIPTION provided by applicant Mental disease including schizophrenia depression and autism spectrum disorders are still poorly understood although it is clear that they mostly represent cortical disorders The cortex is the primary site of higher mental functions yet despite extensive research there is still no unified theory of how the cortex works This is partly due to the fact that ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. A Biomimetic Prehensile Digit for Upper-Limb Amputees

    SBC: Invisible Hand Enterprises, LLC            Topic: NICHD

    DESCRIPTION provided by applicant Prostheses reduce the incidence of contralateral overuse syndrome in upper limb amputees by encouraging balanced bimanual limb usage Benefits include reduced pain and muscular atrophy increased productivity and self reliance improved self image a sense of well being and increased social acceptance Body powered prostheses are used extensively in the Uni ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Galectin 1: A novel small protein therapy for Duchenne muscular dystrophy

    SBC: STRYKAGEN CORPORATION            Topic: NIAMS

    DESCRIPTION provided by applicant Duchenne Muscular Dystrophy DMD is a fatal muscle disease affecting in every male births DMD results from mutations in the gene encoding the dystrophin a kDa scaffolding protein responsible for providing a mechanical link between the muscle fiber actin cytoskeleton and a transmembrane protein complex called the dystrophin associated glycoprotein ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Identification of Borrelia burgdorferi diagnostic biomarkers in humans and nonhum

    SBC: DxDiscovery Incorporated            Topic: NIAID

    DESCRIPTION provided by applicant The number of Lyme disease cases in the US has been recently estimated by the CDC at cases year This is major public health concern Currently available diagnostics rely on detection of the antibody response serology to Borrelia burgdorferi the causative agent of Lyme disease However serological tests are not accurate during the early stages of Ly ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Point-of-care immunoassay for early diagnosis of pertussis

    SBC: DxDiscovery Incorporated            Topic: NIAID

    DESCRIPTION provided by applicant Pertussis is a serious and potentially life threatening respiratory disease caused by the bacterium Bordetella pertussis Worldwide million people become ill with pertussis each year and of these patients die Despite high vaccine coverage in the United States there were still over pertussis cases reported in the U S in Rapid diagn ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. INNOVATIVE OPTICAL SYSTEM FOR HEMAGGLUTINATION ASSAYS

    SBC: INDEVR, INC.            Topic: NIAID

    DESCRIPTION provided by applicant We propose to eliminate the time consuming manual plate readout for hemagglutination assays by developing an innovative well plate and associated optical reader capable of accurately and rapidly determining hemagglutination and associated titer values in a fully automated system The need for improved analytical tools for vaccine development and produc ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Long-Acting G-CSF Analog for Treating ARS

    SBC: BOLDER BIOTECHNOLOGY INC            Topic: NIAID

    DESCRIPTION provided by applicant Development of radiological nuclear medical countermeasures to treat Acute Radiation Syndrome ARS is a high priority research area for NIAID Bone marrow is one of the most sensitive tissues to radiation damage and impaired hematopoiesis is one of the first clinical signs of excessive radiation exposure often resulting i death Granulocyte colony stimulating ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  9. Adjustable Helmet Array for Neonatal Magnetoencephalography

    SBC: QUSPIN INC.            Topic: NICHD

    DESCRIPTION provided by applicant The goal of this project is to develop a very low cost whole head neonatal MEG system that can adapt to the shape and size of the head Clinically there is a longstanding need for a technology that can aid in the diagnosis and prognosis of babies with brain dysfunction due to intrauterine and postnatal central nervous system insults which may result in menta ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  10. TITER ON CHIP ALTERNATIVE TO SRID FOR INFLUENZA VACCINE POTENCY DETERMINATION

    SBC: INDEVR, INC.            Topic: NIAID

    DESCRIPTION provided by applicant It is widely acknowledged that for split vaccines potency determination is often a rate limiting step The FDA approved andquot gold standardandquot potency assay for influenza hemagglutinin HA protein based vaccines is single radial immunodiffusion SRID SRID is a time and labor intensive assay often requiring days to complete and a minimum of hou ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
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