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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Engineering probiotics to biosynthesize natural substances for microbiome brain research

    SBC: HGG Research LLC            Topic: R

    PROJECT SUMMARY To advance microbiome brain studies the general goals of this collaborative proposal are to provide services to research community by engineering probiotics e g E coli Nissle EcN Bifidobacteria longum Lactobacillus plantarum to biosynthesize various naturally occurring chemicals as prebiotic probiotic conjugates which will be marketed as important laboratory agents ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Preventing Vascular Complications in Type Diabetes Muscle Metabolic Monitoring

    SBC: Infrared Rx, Inc.            Topic: NIDDK

    Project Summary Abstract While much has been accomplished in managing hyperglycemia morbidity and mortality in patients with type diabetes T D often results from cardiovascular complications Evidence suggests peripheral artery disease and skeletal muscle mitochondrial dysfunction One reason is the lack of reliable tools to characterize skeletal muscle microcirculation and mitochondrial capa ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. In Situ Autovaccination against Solid Cancers with Intratumoral Hiltonol Poly ICLC A phase II Adaptive Multicenter Clinical Study

    SBC: Oncovir            Topic: 102

    DESCRIPTION provided by applicant Hiltonol poly ICLC is a stabilized dsRNA therapeutic viral mimic or andapos danger signalandapos that activates multiple elements of innate and adaptive immunity It is a standalone immunomodulator but when properly combined with antigen it generates a comprehensive Th weighted immune response best suited for antiviral and antitumor action This project ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Digital Star HIV Prevention for Youth in Mental Health Treatment

    SBC: VIRTUALLY BETTER INC            Topic: 105

    DESCRIPTION provided by applicant Adolescents in mental health treatment are at greater risk for HIV and other STIs than their peers due to an earlier age of onset of sex less protected sex more sexual partners and more frequent substance use This greater risk is due to multiple factors including cognitive misperceptions affect dysregulation and less self efficacy The numerous adolescent ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Point of care immunoassay for rapid diagnosis of tinea capitis

    SBC: DxDiscovery Incorporated            Topic: NIBIB

    Tinea capitis scalp ringworm is a fungal dermatophyte infection of scalp hair follicles that afflicts of the U S pediatric population Tinea capitis is a major health care disparity because it occurs predominantly among individuals with a disadvantaged socioeconomic background and sub Saharan African descent Diagnosis of tinea capitis is currently dependent on culture and microscopy Both ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Small molecule therapy for metastatic prostate cancer

    SBC: MetCure Therapeutics LLC            Topic: 102

    Enzalutamide resistance is a major obstacle in the treatment of metastatic castration resistant prostate cancer mCRPC Recently we developed a small molecule lead compound GH and demonstrated its potent activity against bone metastatic prostate cancer cells In this Phase I STTR application we hypothesize that GH is a novel lead compound with nanomolar potency against enzalutamide resist ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Development of a Non adjuvanted VLP Vaccine against Stealth H N Influenza

    SBC: EPIVAX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The avian origin H N influenza virus that emerged in humans in China in presents a unique challenge to vaccine development because it is poorly immunogenic Neutralizing antibodies are not detected in acute phase infection Anti H antibody responses are significantly delayed and exhibit low avidity in comparison with antibodies generated following seas ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Online professional development training for promotoras on lupus

    SBC: KDH Research And Communication, Inc.            Topic: NIMHD

    DESCRIPTION provided by applicant KDH Research and Communication KDHRC with the American College of Rheumatology ACR will develop LLPI Latinas con Lupus Promotoras con Informaci n Latinas with Lupus Promotoras with Information a culturally competent unique online professional development course course to improve the ability of promotoras de salud promotoras to raise awareness ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  9. NITRC Image Repository A Commercial Solution to Advancing Data Sharing in Neuroscience

    SBC: TCG, Inc.            Topic: 106

    DESCRIPTION provided by applicant The NIH Blueprint for Neuroscience Research National Institute of Biomedical Imaging and Bioengineering National Institute of Neurological Disorders and Stroke National Institute of Drug Addiction and National Institute of Mental Health have undertaken a historic community wide effort in their support of the funding of the Neuroimaging Informatics Tools an ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  10. I Live Inspired Individually Tailored and Integrated Social Support Network for Tobacco Cessation

    SBC: Live Inspired, LLC            Topic: NIDA

    DESCRIPTION provided by applicant Smoking kills Americans annually exacerbates myriad diseases and costs billions in healthcare and productivity losses Numerous barriers exist to accessing traditional treatment e g costs traveling to and scheduling appointments other logistics Text messaging is an extremely popular communication method Over of all Americans use text m ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health

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