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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Topic 364: SysMet: Integrative Systems Metabolomics

    SBC: OmicsCraft LLC            Topic: NCI

    Metabolomics plays an indispensable role in the growing systems biology approaches to identify reliable cancer biomarkers. Liquid chromatography coupled to mass spectrometry (LC-MS) and gas chromatography coupled to mass spectrometry (GC-MS) have been extensively used for high-throughput comparison of the levels of thousands of metabolites among biological samples. However, the potential values of ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Topic 375: Novel Diagnostic Imaging Modality for Monitoring Tumor Responses to a Hyperthermia Immunotherapy (Moonshot)

    SBC: Imago Systems, Inc.            Topic: NCI

    Immunotherapies have been emerging in the past decades as powerful approaches for cancer treatment. However, the immune system is complex, and therapy efficacy is substantially affected by the tumor microenvironment. For this reason, it is currently difficult to visualize tumor response and predict therapeutic efficacy. In this Contract, Imago Systems, Inc., a company with substantial experience i ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Analytical Tools and Approaches for (Multidimensional) Scholarly Research Assessment and Decision Support in the Biomedical Enterprise

    SBC: NET ESOLUTIONS CORPORATION            Topic: NIDA

    NIHthrough NIDAseeks advanced tools that could be broadly used by the life science community and generate results that would be understood by non scientists as well as professional evaluatorsIn Phase Ithe Contractor completed initial development of ERNIEan accessible big data platform integrating multiple data sources and associated methods for quantitative description of research that would facil ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. To develop a nanoSPRi sparing assay.

    SBC: Luna Innovations Incorporated            Topic: NIAID

    Proposes to develop a novelstandardized immune assay that improves monitoring of several biomarkerscytokinesassociated with immunologic pathways of AD with the constraint of having a limited amount of biological samplesThis overall goal is supported by the following program objectivesPhase IDemonstrate proof of concept of nanoSPRiSAas a sensitive and efficient technique in assessing cytokines in h ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. The objective of this contract is to develop a novel LBL RNA vaccine that can be administered to induce long-lasting protection against HIV challenge.

    SBC: Luna Innovations Incorporated            Topic: NIAID

    Extensive efforts have gone towards safe and effective vaccines for Human Immunodeficiency VirusHIVprevention and treatmentAlthough many strategies have been attempted for HIV vaccine developmentnone have been successfully establishedOne category of vaccines gaining increased popularity is RNA based vaccineswhich are vaccines containing antigens encoded by RNA and can be delivered by viral or usin ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Innovative Oral Formulations for Anti-Tb Drugs

    SBC: Luna Innovations Incorporated            Topic: NIAID

    The overall objective of this Phase II work plan is to develop a WHO certified fixed dose combinationFDCtroche for treatment of pediatric tuberculosisThis SBIR Phasecontract seeks to finalize development of a fixed dose combinationFDCAnti TB formulation that is stable under ambient conditions foryears and palatable to childrenThe goal of this project is to develop an innovative oral formulation fo ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. An Integrated Pan Genome Resistome Platform for Nosocomial Pathogen Surveillance in Hospitals

    SBC: ICBiome            Topic: NIAID

    Nosocomial hospital infections are a significant public health concern as they severely harm patients disrupt normal operations and increase hospital costs To reduce these risks and allow for preemptive responses there is a critical need for routine surveillance of nosocomial pathogens within a hospital environment patients staff ventilation equipment With the decreasing costs of sequenci ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Promoting AdheRence via Objective Technology to Assess Cystic Fibrosis Treatment PROTRACT

    SBC: BARRON ASSOCIATES, INC.            Topic: NHLBI

    Significance The proposed research Promoting AdheRence via Objective Technology to Assess Cystic Fibrosis Treatment PROTRACT will develop a novel cost effective system that combines multiple sensing modalities to provide an accurate practical and affordable method for reliably assessing adherence to treatment of cystic fibrosis CF Problem to be Addressed CF is a life shortening disea ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Development of Peptide Inhibitor of Complement to treat neonatal asphyxial brain damage

    SBC: Childrens Specialty Group PLLC            Topic: NIAID

    Abstract The hypothesis for the proposed project is that inhibition of the classical complement pathway with Peptide Inhibitor of complement C PIC will be neuroprotective in a rat model of neonatal hypoxic ischemic encephalopathy HIE HIE is an ischemia reperfusion injury of the brain that occurs around the time of birth with up to mortality and of survivors left with a significant ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Reducing Cervical Cancer Health Disparities among African American Women An mHealth Approach to Improving Prevention and Treatment Outcomes

    SBC: ISA ASSOCIATES INC            Topic: NIMHD

    African American women in the United States continue to be disproportionately burdened by cervical cancer The incidence rate is higher in black women than white women Black women are also twice as likely to die from the disease The year survival rate is for black women It is for white women And yet it does not have to be this way A multifaceted preventive approach could potent ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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