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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A cloud based software platform to enhance reproducibility collaboration and translation of stem cell research

    SBC: Cellara, LLC            Topic: 400

    Project Summary Stem cell research has shown great potential to help treat or even cure a wide array of health conditions including cardiovascular and neurological disease cancer and diabetes This field is now beginning to move rapidly from the re search stage to clinical translation and commercial applications However it has been widely recognized that stem cell scientists have difficulty ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. A Metabolism Based Test to Diagnose Autism Spectrum Disorder and its Subtypes in Early Childhood

    SBC: STEMINA BIOMARKER DISCOVERY, INC            Topic: 101

    DESCRIPTION provided by applicant Autism spectrum disorder ASD is now diagnosed in of children with recent reports citing as many as in children in the United States The average age of diagnosis is more than years There is a need for a reliable biomarker based test for earlier diagnosis of ASD in young children to improve outcomes such as cognition social function and communic ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  3. A Microfluidic System for POC Molecular Diagnosis of HPV in Oral Fluids

    SBC: LUCIGEN CORPORATION            Topic: NIDCR

    DESCRIPTION provided by applicant The human Papilloma Virus HPV causes a wide variety of diseases in humans including squamous papilloma focal epithelial hyperplasia verruca vulgaris and condyloma acuminatum In addition to benign diseases HPV infection is implicated as an etiologic agent in malignancies including cervical and anogenital cancer HPV has been identified as the most commo ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. A Novel Defined Xenobiotic Free Substrate that Mimics Natural Extracellular Matrix

    SBC: PRIMORIGEN BIOSCIENCES INC.            Topic: 200

    DESCRIPTION provided by applicant Primorigen Biosciences SBIR Proposal Abstract Primorigen Biosciences will develop a defined xenobiotic free synthetic cell culture matrix that fully supports maintenance and directed differentiation of human induced pluripotent stem cells hiPSCs down all three germ layers and dramatically reduces the costs of stem cell culture processes The current most co ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. A Novel Device to Monitor and Quantify Early Hypovolemia due to Hemorrhage

    SBC: Simplex Scientific            Topic: 300

    DESCRIPTION provided by applicant Simplex Scientific LLC Simplex is proposing to develop a medical device that can accurately measure hypovolemia due to hemorrhage from trauma which can lead to shock and ultimately death and which will be suitable for deployment at civilian and military trauma sites and during transport where motion induced artifacts interfere with conventional technologies ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. A Novel Strategy to Identify Substances that Improve Mitochnodrial Fitness

    SBC: CYTEGEN CORP            Topic: NIA

    Project Summary Abstract Mitochondrial dysfunction causes mitochondrial diseases and is tightly linked to aging and neurodegenerative disorders such as Parkinsonandapos s and Alzheimerandapos s Recent discoveries support that mitochondrial dysfunction can be overcome to treat age related decline Cytegenandapos s hypothesis is that exercise induces the secretion of blood borne proteins that act ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. A Novel Substrate to Amplify Growth Factor Impact on hPSC Differentiation

    SBC: PRIMORIGEN BIOSCIENCES INC.            Topic: 300

    DESCRIPTION provided by applicant Primorigen Biosciences R Project Abstract Primorigen will use SBIR funds to develop a paradigm changing technology for expansion and directed differentiation of human pluripotent stem cells hPSCs using a novel peptide that dramatically reduces costs by amplifying the impact of endogenous growth factors and minimizing the need for exogenous growth factors Th ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Accurate protein folding software to predict ligand induced conformational changes in G protein coupled receptors

    SBC: DNASTAR, INC.            Topic: 100

    Abstract In humans and animals G protein coupled receptors GPCRs are embedded on cell surfaces and function as key regulators of physiological events by transmitting signals from extracellular stimulants across the cell membrane into the cell Impaired or abnormal GPCR function can result in disordered physiological processes causing a broad and diverse range of diseases For this reason GPCRs ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  9. An innovative tool for assessment of gait dysfunction in the clinical setting

    SBC: METRIA INNOVATION, INCORPORATED            Topic: N

    DESCRIPTION provided by applicant The overall goal of this SBIR Phase II proposal is to develop and validate a fully commercialized instrumented gait analysis system and associated training and reporting tools Gait dysfunction can dramatically affect a personandapos s ability to perfor activities of daily living and assessment of gait is a critical component of physical therapy practice Cur ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Antibacterial molecular coatings pre-fabricated for biologic wound dressings

    SBC: IMBED BIOSCIENCES, INC            Topic: NIAMS

    DESCRIPTION provided by applicant Clinical infections in burn trauma and surgical wounds represent a huge economic and health care burden In the U S there is a infection rate in surgical wounds and up to a rate in burn wounds The current standard of care is intensive and expensive involving frequent topical application of antimicrobials twice daily with painful dressing changes ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health

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