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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Topic 364: SysMet: Integrative Systems Metabolomics

    SBC: OmicsCraft LLC            Topic: NCI

    Metabolomics plays an indispensable role in the growing systems biology approaches to identify reliable cancer biomarkers. Liquid chromatography coupled to mass spectrometry (LC-MS) and gas chromatography coupled to mass spectrometry (GC-MS) have been extensively used for high-throughput comparison of the levels of thousands of metabolites among biological samples. However, the potential values of ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Topic 380- QIDS: Using Radiomics to Impact Radiotherapy Treatment Planning- Moonshot

    SBC: HealthMyne, Inc.            Topic: NCI

    HealthMyne proposes developing a Clinical Decision Support tool to be used in the point-of-care workflow for the Radiation Oncologist that uses radiomic features that have evidence-based association to disease course and/or normal organ damage, in order to impact the treatment planning process. Phase 1 will focus on extraction, calculation, and validation of identified radiomic features for lung c ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Biomaterials for mRNA based cellular reprogramming

    SBC: Stem Pharm, Incorporated            Topic: 100

    Project Summary Abstract Induced pluripotent stem cells iPSCs hold great promise in the areas of disease modeling and regenerative medicine and as a result have unique commercial potential There are currently more than ongoing clinical trials in stem cell therapies including the first in human trial using human iPSC derived retinal pigment epithelial cells to treat ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. HTS Assays for Targeting the cGAS STING Pathway in Autoimmune Diseases and Cancer

    SBC: Bellbrook Labs, LLC            Topic: 300

    SUMMARY Cytoplasmic nucleic acids alert the immune system to invading pathogens and trigger a robust type I interferon IFN response via activation of the STING stimulator of interferon genes receptor The sensor for cytoplasmic nucleic acids was recently discovered to be a cyclic GMP AMP synthase which produces a unique cyclic dinucleotide second messenger cGAMP that serves as an agonist fo ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Automation of MicroC as a CDx for myeloma therapies

    SBC: Lynx Biosciences, Inc.            Topic: 102

    Multiple myeloma MM is a debilitating and currently incurable hematological malignancy While the median survival has increased to years MM patients ultimately relapse and become resistant to therapy Once they reach this stage it is often a trial and error process until an effective therapy can be found Furthermore the MM bone marrow tumor microenvironment plays a significant role in ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. A Novel Strategy to Identify Substances that Improve Mitochnodrial Fitness

    SBC: CYTEGEN CORP            Topic: NIA

    Project Summary Abstract Mitochondrial dysfunction causes mitochondrial diseases and is tightly linked to aging and neurodegenerative disorders such as Parkinsonandapos s and Alzheimerandapos s Recent discoveries support that mitochondrial dysfunction can be overcome to treat age related decline Cytegenandapos s hypothesis is that exercise induces the secretion of blood borne proteins that act ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Highly sensitive isothermal method and instrument for field diagnostics to facilitate malaria eradication

    SBC: CASCADE BIOSYSTEMS, INC.            Topic: NIAID

    Plasmodium falciparum is the most virulent form of malaria causing million deaths per year Success with patient treatment and a malaria eradication campaign depends significantly on our ability to detect new infections as early as possible in the field rural areas including asymptomatic cases preferably using a small amount of blood e g from a finger prick and to clearly discrim ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. A cloud based software platform to enhance reproducibility collaboration and translation of stem cell research

    SBC: Cellara, LLC            Topic: 400

    Project Summary Stem cell research has shown great potential to help treat or even cure a wide array of health conditions including cardiovascular and neurological disease cancer and diabetes This field is now beginning to move rapidly from the re search stage to clinical translation and commercial applications However it has been widely recognized that stem cell scientists have difficulty ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Graphene based Nanosensor Device for Rapid Onsite Detection of Dissolved Lead in Tap Water

    SBC: NANOAFFIX SCIENCE LLC            Topic: NIEHS

    PROJECT SUMMARY There is an increasing public concern about monitoring water quality in the entire drinking water supply system especially at the point of use spurred by recent water catastrophes such as the one in Flint Michigan that has caused severe health issues for thousands of children due to the unsafe level of lead in contaminated drinking water Current quantitative detection methods ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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