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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Passive Exoskeleton for Children with Neuromuscular Disorders

    SBC: RUSH RIVER RESEARCH CORPORATION            Topic: NICHD

    Project Summary Abstract Rush River ResearchRRRCorporation proposes to develop and commercialize a novel passive exoskeleton that helps young children with very little residual strength to use their armsThe proposed orthosis could help the overchildren with many different neuromuscular disorders including muscular dystrophyspinal muscular atrophycerebral palsyarthrogryposis multiplex congenitalAMC ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Noninvasive Functional Cortical Mapping with Innovative tEEG

    SBC: CREmedical Corp            Topic: 106

    PROJECT SUMMARY Resective neurosurgery is essential for treating a range of neurologic conditions such as epilepsy and brain tumorsFor some patientswhose lesion is close to cortical language areaspostoperative expressive or receptive language deficit is a major and feared postoperative complicationMuch effort is devoted to identifying the cortical language regionsand relating such localization to ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. A multivalent, easy-to-use product to mitigate and treat radiation exposure

    SBC: FIBROPLATE, INC            Topic: NIAID

    ABSTRACTThe threat of radiological and nuclear accidents or attacks demands for effective radiation medical countermeasuresMCMable to mitigate and treat the effects of exposure to ionizing radiationsHematopoietic acute radiation syndromeHRASand cutaneous radiation syndromeCRSpose severelife threatening risks to exposed individualsCurrently no effective radio mitigatorto be administered after radia ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Lysis-free extraction of biopharmaceuticals from the periplasm of Clean Genome E. coli

    SBC: SCARAB GENOMICS, LLC            Topic: NIAID

    Thirty percent of recombinant therapeutic proteins are made in Ecoli and include important vaccine components such as carrier proteinsFurtherburgeoning new immunotherapies that use proteins such as single chain antibodies and virus like particles are enjoying increasing successTo meet the production needs of these expanding areasScarab Genomics proposes to extend the versatility of its Clean Genom ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. HLS-Cardiac Safety AI Trained Human Heart and Micro Heart Model

    SBC: Invivosciences, Inc.            Topic: NHLBI

    HLSThe US FDA is considering to establish a new cardiac safety assessment approachdefined by a new paradigm calledComprehensive in vitro Proarrhythmia AssayCIPAThe CIPA willassess drug effects on each cardiac ion channel type individually using a highthroughput assay ion channel assayscompute net effect on repolarization and risks fortorsade pointesTdPusing a mathematical modelandconfirm the compu ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Immunoassay for early diagnosis of mucormycosis

    SBC: DxDiscovery Incorporated            Topic: NIAID

    Mucormycosis is one of the deadliest of the invasive fungal infectionsMucormycosis occurs most often in patients with hematological malignancies undergoing chemotherapypatients who have received hematopoietic stem cell transplants or patients with diabetes mellitusImproved diagnosis is the most frequently noted unmet need for management of the mucormycosis patientDelays in treatment increase the m ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Scalable post-assembly editing software for finishing and annotating personal genomes

    SBC: DNASTAR, INC.            Topic: 300

    We are entering a new era of personal genomics where an individualandapos s genome sequence will be used to identify disease susceptibilityimprove diagnosis and better treat illnesses as well as be combined across cohorts and populations to identify new biomarkers and causal mutations underlying any phenotypeDespite the tremendous success of mapping short read next generation sequencingNGSdata ont ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Developing, Testing and Validating a Wearable Alcohol Biosensor

    SBC: Clinitech, LLC            Topic: 450

    PROJECT SUMMARYThis application for a Phase II SBIR award extends the successful completion of Phase I and represents acollaboration between ClinitechLLC and McLean Hospital Harvard Medical School to continue thedevelopment of a wearable biosensor for detecting alcohol in the interstitial fluid of humansExcessive use ofalcohol accounts for much of the public health burden related to alcohol use di ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Custom-Fit Personal Sound Amplification Smartphone Application

    SBC: ASCENDING HEARING TECHNOLOGIES, LLC            Topic: NIDCD

    PROJECT SUMMARYPersonal sound amplification productsPSAPshave recently become available to the publicPSAPs serve a potentially important role in providing audibility of sounds for adults who have difficulty hearing in some daily living situationsbut may not be candidates for traditionalhigh amplification hearing aidsFewer thanof adults with hearing loss reporting use of hearing aidsciting high cos ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. A novel asthma drug candidate targeting the GABAergic system in lung inflammation

    SBC: PANTHERICS INCORPORATED            Topic: NHLBI

    The proposed research will advance preclinical characterization and validation of a novel drug for asthmaA growing body of research has uncovered functional gamma amino butyric acid type A receptorGABAARsignaling in non neuronal cellsOur research has demonstrated that ligands activating GABAAR subtypes located on airway smooth muscle and immune cells reduce airway hyper responsivenessAHRand inflam ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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