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Project Summary Abstract Induced pluripotent stem cells iPSCs hold great promise in the areas of disease modeling and regenerative medicine and as a result have unique commercial potential There are currently more than ongoing clinical trials in stem cell therapies including the first in human trial using human iPSC derived retinal pigment epithelial cells to treat ...

SUMMARY Cytoplasmic nucleic acids alert the immune system to invading pathogens and trigger a robust type I interferon IFN response via activation of the STING stimulator of interferon genes receptor The sensor for cytoplasmic nucleic acids was recently discovered to be a cyclic GMP AMP synthase which produces a unique cyclic dinucleotide second messenger cGAMP that serves as an agonist fo ...

The goal of this research is to dramatically improve the ability to clone and analyze large and unstable DNA fragments We propose to develop a novel linear cloning vector to maximize stability of cloned DNA in the bacterial host The vector will use the replication proteins of the phage Phi to achieve the highest accuracy of replication for all DNA inserts including AT rich repetitive or str ...

Multiple myeloma MM is a debilitating and currently incurable hematological malignancy While the median survival has increased to years MM patients ultimately relapse and become resistant to therapy Once they reach this stage it is often a trial and error process until an effective therapy can be found Furthermore the MM bone marrow tumor microenvironment plays a significant role in ...

ABSTRACT The principal business interestiFIT Prosthetics LLCwith STTR fundingcreated a new transtibial prosthetic device and demonstrated its safetycomfortand functionIn contrast to conventionally made prosthetic limbsthe iFIT prosthesis is easily fit and aligned on the residual limb in a single sessionDue to its substantial adjustability and customized inner linerthe iFIT device is a comfortable ...

Supported by DOE and NSF SBIR grants for nanomembrane manufacturing and Quality Assurance, Covalent LLC is developing manufacturing methods and materials for a new class of ultra low energy, single atomic layer nanomembranes for Desalination and water purification operating at the lowest possible energy (Topic 15A). The completed membranes are expected to reduce desalination energy requirements b ...

Supported by DOE and NSF SBIR grants for nanomembrane manufacturing and Quality Assurance, Covalent LLC is developing manufacturing methods for a new class of ultra low energy, single atomic layer nanomembranes for Desalination and water Purification operating at the lowest possible energy (Topic 15A). The completed membranes are expected to reduce desalination energy requirements by 66% over cur ...

Electric vehicles are creating unprecedented demand for lithium. Most lithium is produced from brine resources. Conventional methods for extracting lithium from brines suffer from low lithium recovery and cannot access the expanded resources needed for mass adoption of electric vehicles. The Department of Energy has supported a great variety of projects relate ...

Tracking both the extent of the induced fracture and the distribution of the proppant within the fracture are critical in understanding and optimizing the hydraulic fracture processes. Several groups are studying the use of electromagnetic methods and electrically conductive proppants to image the post-fracture proppant distribution. Interpreting these large-scale electromagnetic surveys will like ...

Novel compact and sensitive instruments measuring light scattering from microscopic airborne particles (i.e., aerosols) are needed for deployment on small aerial platforms to characterize aerosol influence on air quality, earth system dynamics, and visibility degradation. The Phase 1 project has developed, modeled, and characterized prototypes of such instruments based on transformative technologi ...