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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Biomaterials for mRNA based cellular reprogramming

    SBC: Stem Pharm, Incorporated            Topic: 100

    Project Summary Abstract Induced pluripotent stem cells iPSCs hold great promise in the areas of disease modeling and regenerative medicine and as a result have unique commercial potential There are currently more than ongoing clinical trials in stem cell therapies including the first in human trial using human iPSC derived retinal pigment epithelial cells to treat ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. HTS Assays for Targeting the cGAS STING Pathway in Autoimmune Diseases and Cancer

    SBC: Bellbrook Labs, LLC            Topic: 300

    SUMMARY Cytoplasmic nucleic acids alert the immune system to invading pathogens and trigger a robust type I interferon IFN response via activation of the STING stimulator of interferon genes receptor The sensor for cytoplasmic nucleic acids was recently discovered to be a cyclic GMP AMP synthase which produces a unique cyclic dinucleotide second messenger cGAMP that serves as an agonist fo ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. High Fidelity Linear MicroVector to Clone Complex Problematic and Large DNAs

    SBC: VARIGEN BIOSCIENCES CORPORATION            Topic: 200

    The goal of this research is to dramatically improve the ability to clone and analyze large and unstable DNA fragments We propose to develop a novel linear cloning vector to maximize stability of cloned DNA in the bacterial host The vector will use the replication proteins of the phage Phi to achieve the highest accuracy of replication for all DNA inserts including AT rich repetitive or str ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Automation of MicroC as a CDx for myeloma therapies

    SBC: Lynx Biosciences, Inc.            Topic: 102

    Multiple myeloma MM is a debilitating and currently incurable hematological malignancy While the median survival has increased to years MM patients ultimately relapse and become resistant to therapy Once they reach this stage it is often a trial and error process until an effective therapy can be found Furthermore the MM bone marrow tumor microenvironment plays a significant role in ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. IMMEDIATE FIT USING INNOVATIVE TECHNOLOGY PROSTHETIC SYSTEMS

    SBC: IFIT PROSTHETICS, LLC            Topic: N

    ABSTRACT The principal business interestiFIT Prosthetics LLCwith STTR fundingcreated a new transtibial prosthetic device and demonstrated its safetycomfortand functionIn contrast to conventionally made prosthetic limbsthe iFIT prosthesis is easily fit and aligned on the residual limb in a single sessionDue to its substantial adjustability and customized inner linerthe iFIT device is a comfortable ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Nanomembrane Interactive Forward Osmosis (FO) Polymers for Desalination and Remediation

    SBC: Covalent LLC            Topic: 15a

    Supported by DOE and NSF SBIR grants for nanomembrane manufacturing and Quality Assurance, Covalent LLC is developing manufacturing methods and materials for a new class of ultra low energy, single atomic layer nanomembranes for Desalination and water purification operating at the lowest possible energy (Topic 15A). The completed membranes are expected to reduce desalination energy requirements b ...

    SBIR Phase I 2017 Department of Energy
  7. Ultra Low Energy, Low Cost Industrial Nanomembrane Substrate for Desalination, Water Purification, and Remediation.

    SBC: Covalent LLC            Topic: 15a

    Supported by DOE and NSF SBIR grants for nanomembrane manufacturing and Quality Assurance, Covalent LLC is developing manufacturing methods for a new class of ultra low energy, single atomic layer nanomembranes for Desalination and water Purification operating at the lowest possible energy (Topic 15A). The completed membranes are expected to reduce desalination energy requirements by 66% over cur ...

    SBIR Phase I 2017 Department of Energy
  8. Ion Exchange Materials for Lithium Extraction (Topic: 15, Subtopic: e)

    SBC: Lilac Solutions, Inc.            Topic: 15e

    Electric vehicles are creating unprecedented demand for lithium. Most lithium is produced from brine resources. Conventional methods for extracting lithium from brines suffer from low lithium recovery and cannot access the expanded resources needed for mass adoption of electric vehicles. The Department of Energy has supported a great variety of projects relate ...

    SBIR Phase I 2017 Department of Energy
  9. Broad Spectrum Electromagnetic Sensing Using Passive and Active Fraction Injection Transient Responses and the Feasibility of Uniquely Separating Fracture and Proppant Distributions

    SBC: Multi Phase Technologies LLC            Topic: 18b

    Tracking both the extent of the induced fracture and the distribution of the proppant within the fracture are critical in understanding and optimizing the hydraulic fracture processes. Several groups are studying the use of electromagnetic methods and electrically conductive proppants to image the post-fracture proppant distribution. Interpreting these large-scale electromagnetic surveys will like ...

    SBIR Phase I 2017 Department of Energy
  10. Integrating Sphere-Based Nephelometer for UAS Applications

    SBC: American Ecotech L.C.            Topic: 17a

    Novel compact and sensitive instruments measuring light scattering from microscopic airborne particles (i.e., aerosols) are needed for deployment on small aerial platforms to characterize aerosol influence on air quality, earth system dynamics, and visibility degradation. The Phase 1 project has developed, modeled, and characterized prototypes of such instruments based on transformative technologi ...

    SBIR Phase II 2017 Department of Energy
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