Award Data

Discriminating viral and bacterial meningitis infections with iDDS probes Confidential PI Shafer David A PhD PROJECT SUMMARY Rapid and accurate molecular diagnostics assays empower physicians to make informed treatment decisions especially when a disease state may result from variable causes that are indeterminable without such testing Meningitis may be caused by infection with microorganism ...

ABSTRACT The development of transformative therapeutics including the possibility of a cure though gene therapy is the sole mission of Expression Therapeutics and continues to be a major research and development activity in the overall $ B USD hemophilia market space However progress in the field has been limited by significant hurdles including the size complexity instability immunogenic ...

Project Summary Abstract Induced pluripotent stem cells iPSCs hold great promise in the areas of disease modeling and regenerative medicine and as a result have unique commercial potential There are currently more than ongoing clinical trials in stem cell therapies including the first in human trial using human iPSC derived retinal pigment epithelial cells to treat ...

KDH Research andamp Communication KDHRC submits this Fast Track SBIR proposal to develop and evaluate AVOID Anti Vaping Online Information Dissemination a media based online toolkit to support community based organizations CBO prevention programming against youth e cigarette e cig use Youth e cig use also known as vaping is a rapidly growing public health threat with use among hi ...

Project Summary Abstract Despite mandatory use of hand sanitizer on cruise ships there are reported cruise ship onboard norovirus outbreaks in exceeded the number of norovirus outbreaks outbreaks onboard cruise ships in One of the problems of currently available alcohol based hand sanitizer is that alcohol evaporates in less than seconds after each application to a surface ...

Metastatic castration resistant prostate cancer CRPC PCa accounts for of PCa deaths and is associated with skeletal metastases CRPC affects patients differently making this disease difficult for physicians to provide standardized treatments with similar outcomes Docetaxel can prolong the overall survival in patients with metastatic CRPC but current therapies do not provide a cure Doce ...

Abstract The liver is the most common organ for metastasis of various cancersincluding pancreaticovariancolorectalgastric cancers and melanomaUveal melanoma metastasizes inof patients and upon metastasis targets the liver inof these casesThe most common primary malignant liver cancer worldwide is hepatocellular carcinomaHCCThe use of blind liver biopsy as a diagnostic tool for liver cancer has man ...

PROJECT SUMMARY To advance microbiome brain studies the general goals of this collaborative proposal are to provide services to research community by engineering probiotics e g E coli Nissle EcN Bifidobacteria longum Lactobacillus plantarum to biosynthesize various naturally occurring chemicals as prebiotic probiotic conjugates which will be marketed as important laboratory agents ...

Project Summary Abstract The two major obstacles to progress in glycomics relative to proteomics and genomics are the lack of simple robust and automated methods for determining glycan structures and for synthesis of glycans The net result of this situation is an overall lack of defined glycans for use in functional studies and for use as standards in structural analysis Significant effort has ...

Project Summary OC Go Facilitating fidelity and dissemination of evidence based treatment for childhood OCD via an interactive crowd sourced patient provider tool The long term objective of this project is to leverage mobile technologies and crowdsourcing to create a new paradigm of evidence based treatment delivery and dissemination as current methods are often insufficient The project seeks ...