You are here

Award Data

For best search results, use the search terms first and then apply the filters
Reset

The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Brain-enriched microRNAs detectable in plasma as biomarkers of Alzheimer's disease

    SBC: DIAMIR, LLC            Topic: NIA

    SUMMARY Aboutof Americans agehave Mild Cognitive ImpairmentMCIof whichprogress to dementia annuallyA growing number of companies are developing new therapeutics aiming to intervene early in the development of Alzheimerandapos s diseasethe most common form of dementiaand there is a great need for accurateminimally invasive diagnostics for primary screening of individuals with earlyincluding presymp ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  2. A user friendly point of care device for G PDH determination

    SBC: ANALYTICAL DIAGNOSTICS SOLUTIONS            Topic: NIAID

    Malaria caused by Plasmodium vivax threatens over billion people globally and sickens tens of millions annually Radical cure for P vivax malaria includes therapy aimed both at the acute attack blood schizontocidal and against future attacks hypnozoitocidal The only hypnozoitocide available are aminoquinolines such as primaquine or tafenoquine However clinicians often do not prescribe ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Interstitial Intensity Modulated Photodynamic Therapy i IMPDT

    SBC: SIMPHOTEK, INC.            Topic: 102

    Over worldwide cases of head and neck Handamp N cancer occur annually Despite aggressive treatment about of Handamp N cancers recur and progress Recent studies of interstitial PDT I PDT have shown promising results in the treatment of patients with locally advanced Handamp N cancer that fail standard therapies I PDT provides a means to treat cancerous tumors while minimizing da ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Improved cleaning technology for reducing risk of transmitting infection in endoscopy

    SBC: ADVANCED BIODEVICES, LLC            Topic: NIAID

    Project Summary Abstract More than million procedures were performed with GI endoscopic devices in Since endoscopes cannot be sterilized risk of infection from contaminated endoscopes can be tangible and needs to be urgently addressed Infection at endoscopy has recently been recognized as a significant risk after two patient deaths from CRE infection transmitted by contaminated duodenos ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Biomaterials for mRNA based cellular reprogramming

    SBC: Stem Pharm, Incorporated            Topic: 100

    Project Summary Abstract Induced pluripotent stem cells iPSCs hold great promise in the areas of disease modeling and regenerative medicine and as a result have unique commercial potential There are currently more than ongoing clinical trials in stem cell therapies including the first in human trial using human iPSC derived retinal pigment epithelial cells to treat ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. A Topical Non-steroidal Anti-inflammatory for Atopic Dermatitis

    SBC: SIGNUM BIOSCIENCES, INC.            Topic: NIAID

    SUMMARY Atopic dermatitis is a chronic dermatological condition afflicting mostly infants and young childrenCurrent treatments are associated with a wide range of side effects therefore development of novel therapeutic agents that are efficacious and have an improved safety profile is neededAlthough disease etiology has yet to be fully understoodskin inflammation is known to be critically involved ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Soluble E NTPDase for sepsis

    SBC: Purine Pharmaceuticals Inc.            Topic: NIGMS

    SUMMARY Sepsis is a medical condition caused by an overwhelming systemic inflammatory response to infection Although the underlying infection can now be efficiently treated with antibiotics there are no effective therapies to control the organ damage caused by the inflammatory response of the host As a result sepsis is the leading cause of mortality in intensive care units and is the tenth lea ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. HTS Assays for Targeting the cGAS STING Pathway in Autoimmune Diseases and Cancer

    SBC: Bellbrook Labs, LLC            Topic: 300

    SUMMARY Cytoplasmic nucleic acids alert the immune system to invading pathogens and trigger a robust type I interferon IFN response via activation of the STING stimulator of interferon genes receptor The sensor for cytoplasmic nucleic acids was recently discovered to be a cyclic GMP AMP synthase which produces a unique cyclic dinucleotide second messenger cGAMP that serves as an agonist fo ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Protein therapeutic to facilitate healing of chronic wounds

    SBC: TRIM-EDICINE, INC.            Topic: 300

    Project Summary This Phase I SBIR proposal targets the development of recombinant human MG rhMG a novel tissue repair protein as a topical therapeutic candidate to facilitate healing of chronic wounds Wound care represents a challenging problem to the public health as no effective treatments for chronic non healing wounds are available MG is an essential component of the cell membrane ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Amplification-Free Target Enrichment and Direct Sequencing of Large Chromosomal Segments

    SBC: GENERATION BIOTECH, LLC            Topic: 172

    This project develops a platform independent target enrichment technology for the preparation of largekbDNA fragmentsThese are magnetically selected from genomic regions of interest and used directlywithout any intermediate amplification stepfor next generation sequencingNGSThis will allow the direct detection of methylated base information on several of the newer NGS systemsLarge DNA templates ca ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
US Flag An Official Website of the United States Government