Award Data

The speed resolution and high mass accuracy of modern mass spectrometers have revolutionized proteomics particularly for determining fragile post translational modifications that control most cellular processes Accurate identification and quantitation of phosphorylation sites remain a major challenge in proteomics The key weakness with mass spectrometry for phospho proteomics lies in the metho ...

DESCRIPTION provided by applicant The long term goal of this project is to reduce falls in older adults by improving their ability to recover equilibrium during a slip or trip The proposed strategy is to use AMES an FDA cleared non invasive intervention that has been shown to enhance motor performance in able bodied adults and to reduce sensorimotor impairment in both the upper and lower lim ...

The proposed Dynamic Mining and Contextualization of the Scientific Literature DMCSL provides an open lane of communication between authors science journals readers and databases The outcome of this communication portal will be a database containing mineable metadata for researchers reagent supply and biotech companies Data will be available to companies through individualized subscription ...

The overarching goal of the proposed research is to demonstrate the feasibility of modifying an existing effective computer based tobacco prevention program Click City Tobacco funded by NIH R CA to prevent the initiation of e cigarette use e g e cigarettes and other vaping devices among youth Click City Tobacco is a school based program for th graders with a booster in th ...

Project Summary Abstract Induced pluripotent stem cells iPSCs hold great promise in the areas of disease modeling and regenerative medicine and as a result have unique commercial potential There are currently more than ongoing clinical trials in stem cell therapies including the first in human trial using human iPSC derived retinal pigment epithelial cells to treat ...

Abstract Although an efficient prophylactic vaccine is available for hepatitis B virus HBV chronic hepatitis B CHB affects up to million people worldwide and despite advances remains mostly incurable In adults acute HBV infection is cleared in of cases by CD T cell mediated mechanisms but chronic lifelong infection ensues in the remaining individuals which can lead to liver ci ...

Chikungunya virusCHIKVis an alphavirus that has gained significant attention due to its ability to cause large epidemics among susceptible populations and to be spread beyond endemic countries by international travelersAmong a population of approximatelyon the French island of La Reunionpeople were infected and overCHIKV related fatalities occurred during theoutbreakLikewisean estimatedmillion peo ...

SUMMARY Cytoplasmic nucleic acids alert the immune system to invading pathogens and trigger a robust type I interferon IFN response via activation of the STING stimulator of interferon genes receptor The sensor for cytoplasmic nucleic acids was recently discovered to be a cyclic GMP AMP synthase which produces a unique cyclic dinucleotide second messenger cGAMP that serves as an agonist fo ...

The goal of this research is to dramatically improve the ability to clone and analyze large and unstable DNA fragments We propose to develop a novel linear cloning vector to maximize stability of cloned DNA in the bacterial host The vector will use the replication proteins of the phage Phi to achieve the highest accuracy of replication for all DNA inserts including AT rich repetitive or str ...

ABSTRACT Adolescents in the juvenile justice system demonstrate very high rates of tobacco alcohol and other drug use ATOD with rates that are estimated to be three times higher than non justice involved youth Substance abusing youth especially those who are involved in the juvenile justice system are at higher risk than nonusers for mental health problems including depression conduct ...