Award Data

The speed resolution and high mass accuracy of modern mass spectrometers have revolutionized proteomics particularly for determining fragile post translational modifications that control most cellular processes Accurate identification and quantitation of phosphorylation sites remain a major challenge in proteomics The key weakness with mass spectrometry for phospho proteomics lies in the metho ...

DESCRIPTION provided by applicant The long term goal of this project is to reduce falls in older adults by improving their ability to recover equilibrium during a slip or trip The proposed strategy is to use AMES an FDA cleared non invasive intervention that has been shown to enhance motor performance in able bodied adults and to reduce sensorimotor impairment in both the upper and lower lim ...

The proposed Dynamic Mining and Contextualization of the Scientific Literature DMCSL provides an open lane of communication between authors science journals readers and databases The outcome of this communication portal will be a database containing mineable metadata for researchers reagent supply and biotech companies Data will be available to companies through individualized subscription ...

The overarching goal of the proposed research is to demonstrate the feasibility of modifying an existing effective computer based tobacco prevention program Click City Tobacco funded by NIH R CA to prevent the initiation of e cigarette use e g e cigarettes and other vaping devices among youth Click City Tobacco is a school based program for th graders with a booster in th ...

Project Summary Abstract Behavioral parent trainingBPTis the gold standard treatment for disruptive behavior in preschool and elementary school age childrenDespite clear empirical evidence that it is effectiveadoption rates by practitioners remains woefully low due in part to a shortage of clinicians trained in BPTIn additioneven when BPT is administeredit is often done incorrectlyThe current stud ...

Project Summary Abstract Induced pluripotent stem cells iPSCs hold great promise in the areas of disease modeling and regenerative medicine and as a result have unique commercial potential There are currently more than ongoing clinical trials in stem cell therapies including the first in human trial using human iPSC derived retinal pigment epithelial cells to treat ...

There is an urgent need for more effective mechanisms that leverage current technologies and best practices to both identify capacity and refer patients to drug treatment facilitiesThe applicant organizationOpenBeds Incis partnering with the non profit MESH Coalitionthree of the largest health care systems offering drug treatment in Indiana and the Indiana Division of Mental Health and AddictionDM ...

Project SummaryWhile the mosquito borne illness malariais entirely preventable and treatablecountries are currently plagued by malaria transmission and half the world s population is at risk of malariaA great deal of progress has been made against malaria as a result of the massive rollout of resources and technology focused on malaria controlThirty five of theaffected countriesincluding China and ...

Abstract Although an efficient prophylactic vaccine is available for hepatitis B virus HBV chronic hepatitis B CHB affects up to million people worldwide and despite advances remains mostly incurable In adults acute HBV infection is cleared in of cases by CD T cell mediated mechanisms but chronic lifelong infection ensues in the remaining individuals which can lead to liver ci ...

Scarab Genomics goal is to commercialize carrier proteins for conjugate vaccine manufacture This proposal focuses on two bacterial carrier proteins that have been approved by the FDA and that are in use in pre clinical and clinical studies Exoprotein A EPA from Pseudomonas aeruginosa and Protein D PD from non typeable Haemophilus influenzae These proteins are difficult to make by the conve ...