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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Low Cost Online Real Time Metal Analysis during Pharmaceutical Manufacturing

    SBC: UHV TECHNOLOGIES, INC.            Topic: NIDA

    The purpose of this SBIR Phase II contract is to develop an inexpensive and easy to use instrument that will becapable of measuring low ppm levels at least andlt ppm of a range of metals typically used in the pharmaceuticalindustry The instrument would be co located with the reaction and purification equipment where metal removalis performed and preferably amenable to continuous monitoring ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Rapid and Low cost POC Assay for Zika Virus Diagnosis

    SBC: AI BIOSCIENCES, INC.            Topic: NIAID

    PROJECT SUMMARY The aim of this proposal is to develop a rapid low cost and easy to use POC diagnostic test for Zika virus ZIKV ZIKV is an emerging mosquito borne Flavivirus that has gained global attention due to new evidence that it is linked to birth defect microcephaly Additionally health experts are also concerned about the link between the virus and Guillain Barr syndrome GBS Pres ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Novel multifunctional oligosaccharide for treating sepsis and severe sepsis

    SBC: AyuVis Research Limited            Topic: NIAID

    Project Summary Hyper inflammation induced by bacteria or bacterial products through toll like receptor TLR leads to sepsis and hence current approaches are directed towards blockade of such receptors While many such candidate antagonists have shown promise they also result in induction of inappropriate innate immune responses thus increasing risk of development of shock leading to death W ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Sensitive and Portable Physician Office Based Urine Analyzer to Tackle Prescription Drug Abuse

    SBC: BreviTest Technologies, Inc.            Topic: NIDA

    PROJECT SUMMARY The United States is in the midst of a prescription opioid epidemic Deaths from misuse daily exceed deaths from heroin overdose and account for nearly one fifth of all drug related deaths The estimated burden on the US healthcare system was $ billion in and increased to an estimated $ billion annually in A key recommendation of several federal agencies is t ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Portable High surety Detection of Zika Virus Directly in Mosquitoes and Humans

    SBC: Paratus Diagnostics            Topic: NIAID

    PROJECT SUMMARY ABSTRACT Zika virus ZIKV an emerging arbovirus transmitted by the Aedes mosquitoes has been correlated with newborn microcephaly and Guillain Barre syndrome in adults The World Health Organization has declared Zika a public health emergency and is calling for new diagnostics and enhanced surveillance In particular point of care POC diagnostics that enable rapid sharing of ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Novel AMPK Activators for the Treatment of Neuropathic Pain

    SBC: CERSCI THERAPEUTICS INCORPORATED            Topic: 300

    Project Summary Abstract NIH Phase I SBIR Proposal Company CerSci Therapeutics PI Scott Dax Title Novel AMPK Activators for the treatment of neuropathic pain Chronic pain contributes to over $ billion worth of healthcare expenditures annually more than the yearly cost of cancer heart disease and diabetes combined Neuropathic pain affects between and of the population and is assoc ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Biomaterials for mRNA based cellular reprogramming

    SBC: Stem Pharm, Incorporated            Topic: 100

    Project Summary Abstract Induced pluripotent stem cells iPSCs hold great promise in the areas of disease modeling and regenerative medicine and as a result have unique commercial potential There are currently more than ongoing clinical trials in stem cell therapies including the first in human trial using human iPSC derived retinal pigment epithelial cells to treat ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Lead Compound Discovery from Engineered Analogs of Occidiofungin

    SBC: Sano Chemicals, Inc.            Topic: NIAID

    Project Summary Occidiofungin is a cyclic nonribosomally synthesized antifungal peptide with submicromolar fungicidal activity against a broad spectrum of fungi Occidiofungin is produced by the Gram negative bacterium Burkholderia contaminans From our structural characterization studies occidiofungin was determined to have a unique chemical composition Our studies have also revealed that occi ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Aminooxyacetic Acid Prodrugs for Colon Cancer Therapy

    SBC: CBS THERAPEUTICS, INC.            Topic: 102

    ABSTRACT Recent studies of the applicants support the role of the endogenous gaseous biological mediator hydrogen sulfide H S in colorectal cancer In specific the selective upregulation of cystathionine synthase CBS and the subsequent production of H S in colonic cancer cells serves as a pro survival factor by stimulating tumor cell bioenergetics ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Aspirin-PC for Chemoprevention of Colorectal Cancer

    SBC: PLx Opco Inc.            Topic: NCI

    ABSTRACT Colorectal cancerCRCis the third leading cause of cancer related deaths in the U SBased on numerous epidemiological studies and recent prospective clinical trialsthe use of daily aspirin is associated with a significant reduction in CRC incidencedeaths and metastatic spreadHoweverthe chronic use of this drug is limited due to the side effects of gastrointestinal bleeding ulceration in sus ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
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