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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. An Integrated Pan Genome Resistome Platform for Nosocomial Pathogen Surveillance in Hospitals

    SBC: ICBiome            Topic: NIAID

    Nosocomial hospital infections are a significant public health concern as they severely harm patients disrupt normal operations and increase hospital costs To reduce these risks and allow for preemptive responses there is a critical need for routine surveillance of nosocomial pathogens within a hospital environment patients staff ventilation equipment With the decreasing costs of sequenci ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Promoting AdheRence via Objective Technology to Assess Cystic Fibrosis Treatment PROTRACT

    SBC: BARRON ASSOCIATES, INC.            Topic: NHLBI

    Significance The proposed research Promoting AdheRence via Objective Technology to Assess Cystic Fibrosis Treatment PROTRACT will develop a novel cost effective system that combines multiple sensing modalities to provide an accurate practical and affordable method for reliably assessing adherence to treatment of cystic fibrosis CF Problem to be Addressed CF is a life shortening disea ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Biomaterials for mRNA based cellular reprogramming

    SBC: Stem Pharm, Incorporated            Topic: 100

    Project Summary Abstract Induced pluripotent stem cells iPSCs hold great promise in the areas of disease modeling and regenerative medicine and as a result have unique commercial potential There are currently more than ongoing clinical trials in stem cell therapies including the first in human trial using human iPSC derived retinal pigment epithelial cells to treat ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Development of Peptide Inhibitor of Complement to treat neonatal asphyxial brain damage

    SBC: Childrens Specialty Group PLLC            Topic: NIAID

    Abstract The hypothesis for the proposed project is that inhibition of the classical complement pathway with Peptide Inhibitor of complement C PIC will be neuroprotective in a rat model of neonatal hypoxic ischemic encephalopathy HIE HIE is an ischemia reperfusion injury of the brain that occurs around the time of birth with up to mortality and of survivors left with a significant ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. HTS Assays for Targeting the cGAS STING Pathway in Autoimmune Diseases and Cancer

    SBC: Bellbrook Labs, LLC            Topic: 300

    SUMMARY Cytoplasmic nucleic acids alert the immune system to invading pathogens and trigger a robust type I interferon IFN response via activation of the STING stimulator of interferon genes receptor The sensor for cytoplasmic nucleic acids was recently discovered to be a cyclic GMP AMP synthase which produces a unique cyclic dinucleotide second messenger cGAMP that serves as an agonist fo ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Reducing Cervical Cancer Health Disparities among African American Women An mHealth Approach to Improving Prevention and Treatment Outcomes

    SBC: ISA ASSOCIATES INC            Topic: NIMHD

    African American women in the United States continue to be disproportionately burdened by cervical cancer The incidence rate is higher in black women than white women Black women are also twice as likely to die from the disease The year survival rate is for black women It is for white women And yet it does not have to be this way A multifaceted preventive approach could potent ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Cardiovascular Hemodynamics Processing System CHAMPS

    SBC: BARRON ASSOCIATES, INC.            Topic: NHLBI

    Summary Abstract Hypertension is a leading cause of excess cardiovascular morbidity and mortality and remains a signi cant national problem with approximately one third of all adults having high blood pressure BP BP monitoring has high diagnostic and prognostic value as an important marker of cardiovascular disease Static BP snapshots which are typically obtained via sphygmomanometry during ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. High Fidelity Linear MicroVector to Clone Complex Problematic and Large DNAs

    SBC: VARIGEN BIOSCIENCES CORPORATION            Topic: 200

    The goal of this research is to dramatically improve the ability to clone and analyze large and unstable DNA fragments We propose to develop a novel linear cloning vector to maximize stability of cloned DNA in the bacterial host The vector will use the replication proteins of the phage Phi to achieve the highest accuracy of replication for all DNA inserts including AT rich repetitive or str ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Speech Perception Training Advanced Scoring and Feedback Methods

    SBC: SeeHear LLC            Topic: NIDCD

    PROJECT SUMMARY Speech perception in noise is a pervasive frustrating problem for older adults with mild to moderate hearing loss Few of these adults qualify for or use hearing aids Auditory speech recognition training is considered a possible intervention but research has failed to deliver reliably effective training regimes to ameliorate speech recognition difficulties Training to improve v ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Automation of MicroC as a CDx for myeloma therapies

    SBC: Lynx Biosciences, Inc.            Topic: 102

    Multiple myeloma MM is a debilitating and currently incurable hematological malignancy While the median survival has increased to years MM patients ultimately relapse and become resistant to therapy Once they reach this stage it is often a trial and error process until an effective therapy can be found Furthermore the MM bone marrow tumor microenvironment plays a significant role in ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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