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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Topic 364: SysMet: Integrative Systems Metabolomics

    SBC: OmicsCraft LLC            Topic: NCI

    Metabolomics plays an indispensable role in the growing systems biology approaches to identify reliable cancer biomarkers. Liquid chromatography coupled to mass spectrometry (LC-MS) and gas chromatography coupled to mass spectrometry (GC-MS) have been extensively used for high-throughput comparison of the levels of thousands of metabolites among biological samples. However, the potential values of ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Topic 380- QIDS: Using Radiomics to Impact Radiotherapy Treatment Planning- Moonshot

    SBC: HealthMyne, Inc.            Topic: NCI

    HealthMyne proposes developing a Clinical Decision Support tool to be used in the point-of-care workflow for the Radiation Oncologist that uses radiomic features that have evidence-based association to disease course and/or normal organ damage, in order to impact the treatment planning process. Phase 1 will focus on extraction, calculation, and validation of identified radiomic features for lung c ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Development of a novel highly effective influenza vaccine

    SBC: Flugen, Inc.            Topic: NIAID

    Seasonal influenzafluvirusan NIAID category C priority pathogencauses widespread infectionresulting in at leastmillion cases of severe illness anddeaths worldwideWhile annual vaccination is recommended for all individuals aged overmonths in the UScurrent vaccines are only aroundeffective and there is an urgent need for safemore effective influenza vaccines that offer broad spectrum protectionTo me ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. A Direct-Reading Liquid Crystal Based Formaldehyde Dosimeter for Personal Exposure Monitoring

    SBC: Platypus Technologies, LLC            Topic: NIEHS

    Platypus Technologies aims to advance the liquid crystalLCbased molecular analytic detection of formaldehyde that it established with SBIR Phase I support to complete the development and integrate its innovative LC based technology into product forms for rapid identification of formaldehyde emissions for short term and time weighted exposureTWAFormaldehyde is a known carcinogenand workplace exposu ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Immersive Virtual Reality as a Tool to Improve Police Safety in Adolescents and Adults with ASD

    SBC: Floreo, Inc.            Topic: 103

    Floreo Technology proposes to develop the Police Safety ModulePSMan innovativeimmersive mobile virtual realityVRapplication designed to train police safety in adolescents and adults with autism spectrum disorderASDASD has been increasing in prevalence over recent yearsWhile much attention has been paid to the causes and early diagnosis of ASDthere remains a clear need for effective interventions f ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. A 3-month Release Naltrexone for Addiction Treatment

    SBC: Plumb Pharmaceuticals LLC            Topic: NIDA

    Opioid misuse is a world wide problemand it is increasingThe epidemic has shifted from a problem largely confined to urban areas to one that is both urban and ruralMaintenance therapy helps alleviate situational cravings and makes addiction therapy more effectivebut methadone clinics are largely confined to larger citiesbuprenorphine must be prescribed by physicians with a specific waiverand it ma ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. CapioCyte circulating tumor cell assay as a biomarker for cancer immunotherapy response

    SBC: CAPIO BIOSCIENCES, INC.            Topic: NCI

    Cancer immunotherapythe utilization of the patientsown immune system to treat cancerhas emerged as a powerful new strategy in cancer treatmentAn unmet need in cancer immunotherapy treatment has been the lack of a predictive biomarker for treatment responseImagingwhich has been thegold standardfor monitoring treatment response is unreliable in immunotherapy due to the pseudoprogression phenomenonAn ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Mobile Support to Improve Recovery and Treatment Court Outcomes

    SBC: Live Inspired, LLC            Topic: NIDA

    PROJECT SUMMARY ABSTRACTDrug Treatment CourtsDTCsare a rapidly evolving alternative to incarceration for non violent drug offenders in the U SPresently there are moreDrug Treatment Courts operating nationwideThese courts take a collaborativenon adversarialteam approach uniting the judgeprosecution and defense attorneys with substance abuse treatment professionals to facilitate effective drug treat ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Synthetic biomaterials designed for the generation of mouse neural organoids for in vitro toxicity screening.

    SBC: Stem Pharm, Incorporated            Topic: NIEHS

    ABSTRACT There is a well recognized need for more accurate and cost effective toxicology screening methods for therapeutic and environmental chemicalsAdvances in the field of stem cell derived brain organoids have led to exploration of these models not only in the study of neural developmentbut also for drug and toxicity screeningHoweverbecause of their costcomplexityand workflow requirementsthese ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. HTS Assays for Targeting the cGAS-STING Pathway in Autoimmune Diseases and Cancer

    SBC: Bellbrook Labs, LLC            Topic: 300

    Project Summary Cyclic GMP AMP synthasecGASis a recently discovered enzyme that acts as a foreign DNA sensor to elicit an immune response to pathogens via activation of the STINGstimulator of interferon genesreceptorThough there are other DNA sensorse gTLRthe cGAS cGAMP STING pathway appears to be essential for DNAmediated immune response irrespective of cell type or DNA sequenceDNA binds to a spe ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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