Award Data

DESCRIPTION provided by applicant A Phase II SBIR program of preclinical development is proposed for the development of an active specific immunotherapeutic called Cellariumandquot for treatment of glial cell based cancers Successful completion of this project will confirm therapeutic effect and pre clinical safety of the vaccine in preparation for first in human studies Upon demonstration of ...

DESCRIPTION provided by applicant The avian origin H N influenza virus that emerged in humans in China in presents a unique challenge to vaccine development because it is poorly immunogenic Neutralizing antibodies are not detected in acute phase infection Anti H antibody responses are significantly delayed and exhibit low avidity in comparison with antibodies generated following seas ...

DESCRIPTION provided by applicant The overall aim of this project is to evaluate the feasibility of using a novel gemcitabine ibandronate conjugate alone and or as part of a combination therapy for the treatment of osteosarcoma and associated metastases The conjugate consists of chemically linked anticancer antimetabolite Gemcitabine and the bone homing bisphosphonate Ibandronate The novel co ...

DESCRIPTION provided by applicant Enteral nutrition using feeding tubes provides a long term means of improving the nutritional status for infants and children with neurological syndromes cancer gastrointestinal disease cardiac disease and metabolic disease by allowing administration of feeding formula directly to the stomach through the upper abdomen More than pediatric percutaneo ...

DESCRIPTION provided by applicant Sickle cell disease SCD is the most common inherited blood disorder in the U S and disproportionately affects African Americans and Hispanics Approximately U S children are born with SCD annually SCD results from abnormal hemoglobin and causes red blood cells RBCs to become misshaped andquot sickle shapedandquot Sickled cells can block the fl ...

DESCRIPTION provided by applicant This study will aim to assess the feasibility and acceptability of using state of the art social media and game technology to increase HIV testing among adolescents and young adults AYA ages Rates of HIV testing among AYA are low resulting in high proportions of AYA who are positive or unaware of their HIV infection Further public health messages wh ...

DESCRIPTION provided by applicant Asthma is the most common chronic childhood disease and the most frequent reason for hospitalization of children It is also the most common chronic respiratory disorder in adults It results in over million emergency department visits and about hospitalizations annually in the U S alone The National Institutes of Health NIH expert guidelines re ...

PROJECT SUMMARY The Hemagglutination assay HA and Hemagglutination Inhibition HI assay are widely used methods for characterizing viruses bacteria and antibodies The World Health Organization recently recommended that HI remain the gold standard method for influenza seroepidemiology Although the HA and HI assays are applied worldwide they have the disadvantages of manual plate reading no ...

Project Summary Pertussis is rapidly re emerging as a serious public health threat in the United StatesDespite high vaccine coverage nationallyannual reported cases in the U Shave been increasing recentlywith ayear high ofinMoreoverreported cases represent a large underestimate of pertussis infectionsDiagnosis of early pertussiscatarrhal stageprior to paroxysmal coughis particularly challenging be ...

DESCRIPTION provided by applicant This project will develop a commercial product that will enable for the first time realtime tumor tracking during radiotherapy at an attractive price point and with minimal interference with standard clinical practice The key novel technology is an optimized multi source X ray tube with focal spots that is placed below the multi leaf collimator MLC of a r ...