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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A Metabologenomics Platform for Large Scale High Throughput Natural Product Discovery

    SBC: Microbial Pharmaceuticals, Inc.            Topic: NCCIH

    ABSTRACT The estimates of natural product producing gene clusters within the genomes of microorganisms are far greater than the number of known natural products indicating that there is a wealth of untapped molecules within these organisms that offer huge potential as leads for new medicines Unfortunately the prevailing paradigms for natural product discovery are ill suited for accessing this ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. A rapid and portable test for home monitoring of phenylalanine levels by patients with phenylketonuria using a blood glucose meter

    SBC: GlucoSentient, Inc            Topic: NICHD

    Project Summary Abstract Phenylketonuria PKU is a serious inborn metabolic disorder affecting out of every children born in the U S annually Characteristic effect of PKU is the impaired capability of the body to convert the amino acid phenylalanine Phe to tyrosine and as a result Phe level is elevated in the blood stream While Phe is required for normal growth and brain developm ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Optimizing NGF for Topical Treatment of Glaucoma

    SBC: HUMAN CELL CO            Topic: N

    Glaucoma is one of the leading causes of blindness in the world This chronic and progressive optic neuropathy is characterized by loss of axons of the retinal ganglion cells RGC that constitute the optic nerve Reduction of elevated intraocular pressure the only modifiable causative factor slow the onset and progression of the disease yet no treatment is available to restore o ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Technology Enabled Mental Health Intervention for Individuals in the Criminal Justice System A

    SBC: Jail Education Solutions, Inc.            Topic: 104

    In the United States over million people are incarcerated While these numbers are alarming even more distressing is the rapid growth in the number of mentally ill individuals caught in this system Within any given year approximately of females and of males in jail will experience a mental health problem This results in the criminal justice system serving as a de facto mental ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Recombinant Prothrombin Therapy for Hemorrhage

    SBC: HUMAN CELL CO            Topic: NHLBI

    Uncontrolled bleeding remains one of the leading causes of trauma induced death Current treatment recommendations focus on fresh frozen plasma and blood cell transfusions which do not seem to be effective Over the last few years these is increasing use of prothrombin complex cencentrate to treat hemorrhage associated coagulapathy which is effective but induces disseminated intravascular coagula ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Study of the New HDAC i SW as a Treatment for Alzheimer's Disease and Other Tauopathies

    SBC: Starwise Therapeutics LLC            Topic: NIA

    ABSTRACT Alzheimerandapos s and other tauopathies are medical problems growing to historical proportions that threaten the long term viability of medical care systems world wide Alzheimerandapos s costs today are of the US GDP and growing as the population ages Effective disease modifying treatments have yet to be developed A number of drugs in clinical testing target amyloid but very fe ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. In Home Reading Eye Movement Training System

    SBC: Kilbride, Paul            Topic: N

    Given the rapidly aging population and the incidence of age related eye diseases the number of individuals with low vision is expected to increase dramatically in the next decades Patients with central vision loss can no longer use their foveas and eccentric retina must be used to perform visual tasks Since the peripheral retina has reduced sensory capabilities and altered oculomotor behavior ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Wireless implantable optofluidic systems for programmed pharmacology and optogenetics

    SBC: Neurolux, Inc.            Topic: 101

    Project Summary Abstract Diseases of the central and peripheral nervous systems affect the quality of life of millions of people worldwide Progress in understanding the function of neural networks and in developing associated insights into the underlying causes of these diseases can be accelerated by advances in techniques and methodologies for neuroscience research Collaborative efforts between ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Immersive Virtual Reality as a Tool to Improve Police Safety in Adolescents and Adults with ASD

    SBC: Floreo, Inc.            Topic: 103

    Floreo Technology proposes to develop the Police Safety Module PSM an innovative immersive mobile virtual reality VR application designed to train police safety in adolescents and adults with autism spectrum disorder ASD ASD has been increasing in prevalence over recent years While much attention has been paid to the causes and early diagnosis of ASD there remains a clear need for effec ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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