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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Enhancing cytarabine efficacy in leukemia through CDK inhibition

    SBC: SENEX BIOTECHNOLOGY, INC.            Topic: 102

    Acute myeloid leukemia AML is the most common acute leukemia in adults with new cases annually in the US A deoxycytidine nucleoside analog Cytarabine AraC is the principal chemotherapeutic agent used in AML AraC containing chemotherapeutic regimens induce complete remission in of newly diagnosed AML patients but a substantial minority of leukemias is intrinsically resistant t ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Novel injectable resiquimod formulation for treatment of metastatic cancers

    SBC: Curebiotech, Inc.            Topic: NCI

    PROJECT SUMMARY Malignant melanoma is one of the most aggressive types of skin cancer causing a large majority of skin cancer related deaths worldwide Recently there have been staggering breakthroughs with the advent of drugs that act on checkpoint inhibitors These are paradigm shifting immunotherapeutic agents not only for melanoma but for cancers in general because they harness the bodyan ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. CRISPR Cas Systems Delivered by Targeted Nanoparticles to Eradicate Herpesvirus Pathogens

    SBC: Theragnostic Technologies Inc.            Topic: NIAID

    Abstract Herpesviruses are chronic pathogens that infect for life there is no cure years since the discovery of the first tumor virus the herpesvirus Epstein Barr virus EBV there exist no specific antivirals for EBV during its latency phase and there are no vaccines The same holds true for most of the other eight human herpesviruses This proposal aims to develop novel tools to eradicat ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. A Nitric Oxide Polymer Platform for the Prevention and Treatment of Infected Wounds

    SBC: IFYBER, LLC            Topic: NIAID

    This proposed SBIR research effort will lay the foundation for commercializing a new class of biomaterial for the prevention and treatment of infected skin wounds thereby enhancing patient health through improved patient outcome and reduced patient morbidity Specifically we will focus on evaluating and developing a biomaterial comprised of a nitric oxide NO releasing based on a commonly used ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Fluorescent reporters for real time single cell Pol III transcription measurement

    SBC: Lucerna Inc.            Topic: 400

    SUMMARY RNA polymerase III Pol III is increasingly recognized as an important drug target and a rapidly developing area of academic research Pol III is responsible for generating RNAs that are critical for cell growth such as tRNAs certain rRNAs and various noncoding RNAs involved in processes such as mRNA splicing These RNAs are required for cell growth proliferation and differentiation ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. A phosphopeptide multiplex PRM mass spectroscopic biomarker assay for PAH

    SBC: Pulmokine, Inc.            Topic: NHLBI

    The purpose of this phase SBIR grant is to develop a quantitative phosphopeptide biomarker assay for pulmonary arterial hypertension PAH The commercial product will consist of a kit of stable isotopically labeled internal standards of a selected set of phosphopeptides either up or down regulated in PAH The set of stable isotopically labeled peptides will be used in a parallel reaction monito ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. FMRI Dynamic Phantom for Improved Detection of Resting State Brain Networks

    SBC: ALA SCIENTIFIC INSTRUMENTS, INC.            Topic: NIDA

    Abstract Functional magnetic resonance imaging fMRI has rapidly become the dominant tool in human neuroscience research and is poised to become a transformative technology in the areas of psychiatric and neurological diagnostics In recent years large scale $ M $ B USD and long term year international investments e g NIDA Adolescent Brain Cognitive Development Study NIH Human ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Epigenetic fingerprinting of label free DNA using a solid state nanopore

    SBC: Esper Biosciences Inc            Topic: 172

    Project Summary In an effort to improve the scientific and medical communities ability to access epigenetic information this project aims to develop a label free method to detect epigenetically modified bases in DNA The method that will be developed relies on the use of a carbon nanotube charge sensor integrated with a solid state nanopore DNA will be driven through the nanopore by electropho ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. CDK inhibitor for the treatment of HER breast cancer

    SBC: SENEX BIOTECHNOLOGY, INC.            Topic: 102

    Approximately of breast cancers overexpress oncogenic tyrosine kinase receptor HER NEU Patients with metastatic HER cancer typically receive HER targeting monoclonal antibodies trastuzumab and pertuzumab often combined with a taxane a small molecule HER inhibitor lapatinib or a HER specific antibody drug conjugate T DM are used in later arms of treatment Despite the transformative ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Nature inspired methods for long term banking of endocrine cells within encapsulation devices

    SBC: Sylvatica Biotech, Inc.            Topic: 200

    Project Summary The objective of this study is to investigate and develop long term storage of cells using cryopreservation in the context of improving health of islets for islet transplantation as a Type Diabetes treatment The goal is to develop a high subzero cryopreservation method that cools cells inside protective immunoisolation devices to extend preservation time to weeks and months Our ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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