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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. SnapCap: a device to decontaminate central venous catheters (CVC) with 5 snaps

    SBC: Contech Medical, Inc.            Topic: NICHD

    Project Summary Abstract We propose a new approach to the decontamination of central venous catheters and the prevention of central line associated bloodstream infectionsCLABSIan important healthcare associated infectionCLABSIs cost the US healthcare system approximately $billion annuallyPronovostNEJMAdditionallyCLABSIs can be life threateningespecially in the very young and critically illEven whe ...

    STTR Phase I 2018 Department of Health and Human Services
  2. Caring for the Caregiver: A Theory-Driven Mobile Intervention to Promote Caregiver Well-Being

    SBC: Pro-Change Behavior Systems Inc            Topic: NIA

    Overmillion Americans are currently providing unpaid care to a family memberrelativeor friend with Alzheimer s disease or related dementiaWhile caregiving can be a positive experience that brings meaning and an increased sense of purposeit can also take a tollNearlyof Alzheimer s and dementia caregivers rate their emotional distress as high or very highand as many assuffer from depressionCaregiver ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Development of Spleen Tyrosine Kinase (SYK) negative allosteric modifiers for therapeutic intervention in Alzheimer's disease.


    Pathological hallmarks of Alzheimerandapos s diseaseADinclude extracellular deposits of Apeptidesintraneuronal aggregates of abnormally phosphorylated tau protein and neuroinflammationMost proposed AD disease modifying therapies have focused on strategies that reduce brain Aamyloid or tau pathological accumulationHoweversuch approaches have been unsuccessful in late stage AD clinical trials and ma ...

    STTR Phase I 2018 Department of Health and Human Services
  4. A Phase 2b Clinical Trial to Study the Efficacy of Longeveron Mesenchymal Stem Cells (LMSCs) to Treat Aging Frailty

    SBC: Longeveron LLC            Topic: NIA

    Aging Frailty is a biologically driven geriatric syndrome of multisystem physiological decline that is distinct from normal aging and disproportionately increases vulnerability to adverse clinical outcomesFrailty has an overall prevalence ofof thoseyears and olderand there is growing awareness in the geriatric community to diagnose and treat this conditionas it is not an inevitable consequence of ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Technology for the non-invasive surveilance of post-traumatic compartment syndrome

    SBC: Myolex Inc            Topic: NIAMS

    PROJECT SUMMARYAcute compartment syndromeACSremains one of the most devastating and often overlooked traumatic musculoskeletal disorders in clinical practiceIn this conditionpressure increases in one of the body s spacelimited compartmentsdue most commonly to direct trauma or bone fractureresulting ultimately in an ischemic injury to all of the compartment s contentsincluding muscle and nerveOnce ...

    STTR Phase I 2018 Department of Health and Human Services
  6. Biomaterial-Based Delivery of Suppressor of Cytokine Signaling Mimetics to Ameliorate Type 1 Diabetes

    SBC: ONEVAX, LLC            Topic: NIDDK

    TypeDiabetesT Dresults from a breakdown of self tolerance that is characterized by immune cell mediated destruction of the insulin producingcells in the pancreasUltimatelyglucose metabolism is interrupted resulting in the development of life threatening complications such as heart disease and renal failureT D affects an estimatedmillion Americanswith more thannew patients diagnosed annuallyresulti ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Development of an Oral WNT inhibitor

    SBC: Stemsynergy Therapeutic            Topic: 102

    ABSTRACT Colorectal cancerCRCrepresents the fourth most commonly diagnosed cancer withnew cases each yearUnfortunatelyCRC results in a disproportionate number of deathsprojected indue to advanced stage at diagnosisthe aggressive phenotype of the disease and lack of effective therapeuticsGreater thanof CRC patients possess activating mutations in the WNT signaling pathwayWNT pathway activation is a ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Electrical impedance myography technology for quantitative, at-home muscle assessment in amyotrophic lateral sclerosis and other neuromuscular disorders.

    SBC: Myolex Inc            Topic: NINDS

    Project SummaryTo improve the efficiencyconvenience and quality of ALS clinical trialswe need better biomarkers for assessing amyotrophic lateral sclerosisALSprogression and response to therapyAll recent ALS trials require patients to visit an ALS clinical trials center everymonths at which time assessments are obtainedincluding limb strengthvital capacityand the ALS functional rating scale revise ...

    SBIR Phase II 2018 Department of Health and Human Services
  9. Innovative Electrode Designs for Next Generation Electrical Impedance Myography

    SBC: Myolex Inc            Topic: NIAMS

    Project SummaryElectrical impedance myographyEIMis a non invasive technique for muscle evaluation that is finding increased application in a variety of neuromuscular diseases ranging from amyotrophic lateral sclerosis to muscular dystrophy to radiculopathyIn EIMa weak electrical current is passed between two electrodes through a muscle of interesttwo additional electrodes measure the resulting vol ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Development of an integrated 4-organ animal model

    SBC: Hesperos, Inc            Topic: NIEHS

    Project Summary AbstractWe propose to construct multi organ microphysiological systemsBody on a Chipor BoaCsfrom human and rat cells to use as a basis to understand species differences in response to exposure to drugs or chemicals in this new platformThe results will then be compared to clinical datawhere availableand to archived in vivo animal dataThis work will directly test whether such in vitr ...

    SBIR Phase I 2018 Department of Health and Human Services

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