Award Data

DESCRIPTION (provided by applicant): There is an urgent need to develop novel, cost-effective manufacturing processes to produce therapeutic antibodies commercially in order to reduce the high manufacturing expenses as well as to address the potential for limited manufacturing capacity. The long-term objectives of this application are to develop novel manufacturing processes using transgenic plant ...

DESCRIPTION (provided by applicant): The objective of this project is to develop an anti-tissue factor antibody, Sunol-cH36, as a treatment for Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS). The association between coagulation and inflammation has been well established and a central role in the coagulopathy of ALI/ARDS has been attributed to tissue factor (TF). TF binding ...

DESCRIPTION (provided by applicant): Microarrays are a powerful way to measure the biological impact of contaminants in the environment. Because they are used to test changes in expression of many genes in parallel, they provide data on the mechanisms by which compounds affect health more quickly than methods now in use, which makes them much less expensive than current tests. Today, gene chips (m ...

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DESCRIPTION (provided by applicant): We will develop a modern, computer-controlled electrical stimulator for performing functional mapping by cortical stimulation. The primary application is for use with patients who are candidates for surgery to control or eliminate occurrence of epileptic seizures. Other applications will include functional mapping to plan surgery for other brain diseases such a ...

DESCRIPTION (provided by applicant): Liver injury induced by hepatic ischemia followed by reperfusion is a major pathogenic cause of liver failure during multiple trauma, thermal injury, hemorrhagic and septic shock, and liver transplantation, which contributes significantly to multiple organ failure and mortality. Current enzymatic assays of serum ALT or LDH are either non-specific or not sensiti ...

DESCRIPTION (provided by applicant): During this Phase I SBIR project, Dakota Technologies, Inc. (Dakota) will demonstrate that a simple solid state halogen specific detector can be miniaturized, hardened, and incorporated into a percussion deliverable probe capable of delineating dense non-aqueous phased liquids (DNAPL) in the subsurface in real time. The proposed system will be based on a haloge ...

DESCRIPTION (provided by applicant): Fluorescence based-assays have greatly facilitated high-throughput screening (HTS) in drug discovery. However, in doing so, they created a bottleneck relating to false positives and false negatives, which may arise due to interferences from light scattering, inner filter effects, and compound fluorescence. Unlike fluorescence intensity, a fluorescence lifetime- ...

DESCRIPTION (provided by applicant): Botulinum toxin is classified as a category A biothreat due to its high potency and the potential to be used as a bioweapon. Because there is no FDA-approved vaccine, there is a high priority in rapid development of a vaccine that can be used in the event of an attack. The overall goal of our Phase I project is to develop an orally administered multivalent s ...

FarSounder proposes to develop a low cost 3D sonar system for underwater threat detection. This system will be based on the FarSounder 3D sonar technology and will utilize COTS components which will leverage FarSounder`s advanced processing techniques to increase the system`s performance when compared to currently available port security sonars. For this Phase I effort FarSounder will perform a fe ...