Award Data

DESCRIPTION (provided by applicant): A closed loop, glucose sensing, and insulin responsive system could dramatically improve treatment options for insulin dependent diabetics. Current artificial systems, however, lack the ability to provide this precise control. Clinical islet transplantation, the intrahepatic loading of allogeneic islets, shows the potential to provide this intimate control, by ...

DESCRIPTION (provided by applicant): Principal Investigator/Program Director (Last, First, Middle): Abstract We propose to design and deploy a handheld breath-based "personal" medication adherence monitoring system (MAMS) which will meet the criteria of the solicitation from the National Institute of Mental Health (NIMH) for "Development of information, instruments or methodologies to improve and/ ...

DESCRIPTION (provided by applicant): Building on our Phase I achievements, we will design and deploy a handheld, breath-based medication adherence monitoring system (adherence system) to identify adherence for clinical trials. The system consists of a miniature, battery powered gas chromatograph (the device) capable of measuring volatile metabolites (e.g., butanone) on an individual's breath after ...

DESCRIPTION (provided by applicant): Addiction annually costs America gt 500B. Narcotic addiction is especially worrisome since intravenous drug abuse (IVDA) also promotes HIV transmission. Reducing IVDA is critical to lowering the incidence of HIV. Sincegt75% of IVDA is with opioids, effective treatment of opiate addiction should markedly reduce IVDA and lower HIV transmission rates. Naltrexone ...

Severe patient-ventilator asynchrony affects 12-30% of ventilated patients in the intensive care unit (ICU) or approximately 200,000-500,000 patients annually in the US. Many patients will become asynchronous with the ventilator and will be attempting to exhale when the machine (ventilator) is attempting to move air into the lungs, and vice versa. Severe asynchrony, where asynchrony index (quantif ...

DESCRIPTION (provided by applicant): The proposed project is related to NIMH research topic Assessment of Emotional and Psychological States. The goal is to develop a multidimensional, modular, self-report questionnaire that evaluates the course and outcome of psychiatric treatment. The Multidimensional Assessment of Symptoms and Psychosocial Functioning (MASP) is designed to assess symptom severi ...

DESCRIPTION (provided by applicant): The proposed project is related to NIMH research topic Assessment of Emotional and Psychological States. The goal is to develop a multidimensional, modular, self-report questionnaire that evaluates the course and outcome of psychiatric treatment. The Multidimensional Assessment of Symptoms and Psychosocial Functioning (MASP) is designed to assess symptom severi ...

Project Summary This project proposes further development of a computational discovery platform shown to quantifiably identify and prioritize both targets and compounds for therapeutic intervention, which will accelerate the development of newer, more effective drugs with fewer side-effects. This platform is based on a novel fusion of two state of the art computational approaches (phenolog mapping ...

Project Summary This project proposes implementation of a computational discovery platform that quantifiably identifies and prioritizes both targets and compounds for therapeutic intervention This platform is based on a novel fusion of two state of the art computational approaches phenolog mapping and functional networks with proprietary data from our powerful gene drug screening assays HIP H ...

PROJECT SUMMARYThis project s goal is to develop an innovative cost effective robotic platform for fast on demand pharmacy production of pediatric drugs as individually tailored palatable gummy dosage formsMedication adherence is notoriously low among children due to difficulty swallowing pills and rejection of bad tasting medicationsAlthough some common pediatric drugs have flavored liquid formsp ...