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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. A Randomized Blinded Placebo Controlled Clinical Trial to Evaluate Longeveron Mesenchymal Stem Cell LMSC Therapy for Treating The Metabolic Syndrome

    SBC: Longeveron LLC            Topic: NIA

    The metabolic syndrome MetS is a cluster of factors that increases the risks for cardiovascular disease type diabetes mellitus and mortality and currently affects andgt of US adults MetS is associated with endothelial dysfunction decreased circulating endothelial progenitor cells EPCs and a pro inflammatory state We have made the exciting discovery that therapy with allogeneic me ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Optimizing electrical impedance myography outcomes through data mining

    SBC: Myolex Inc            Topic: NIAMS

    Project summary Electrical impedance myography EIM is a non invasive technology for the assessment of muscle that is based on the application of a weak high frequency electrical current to a muscle and the measurement of the resulting surface voltages The further development and application of EIM remains the main business focus of Skulpt Inc a small business concern based in Boston and San ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Therapeutic TRPA Mechanism Based Treatment of Chemotherapeutic Induced Neuropathic Pain

    SBC: ALGOMEDIX, INC.            Topic: 102

    Abstract Cancer patients treated with many widely used chemotherapeutic agents including paclitaxel PAC and oxaliplatin OXA frequently develop chemotherapy induced peripheral neuropathy CIPN that may lead to dose reduction dosing schedule changes and termination of treatment In some patients acute peripheral neuropathy PN can transition into chronic PN lasting well beyond termination ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Rational drug selection for Alzheimer s disease using Indicator Cell Assay Platform iCAP

    SBC: PreCyte Inc            Topic: NIA

    Project Summary We are developing a novel tool for disease diagnosis called the indicator cell assay platform iCAP that uses standardized cultured cells as biosensors to detect disease status of patients from blood or cerebral spinal fluid CSF samples Here we propose to establish proof of concept for applying the assay to drug discovery by initiating development of the iCAP for drug selectio ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Functional integrated human on a chip systems for Alzheimer s research

    SBC: Hesperos, Inc            Topic: NIA

    Project Summary The goal of this proposal at the end of the Phase II effort is to have a service available to academia and industry to screen drugs for Alzheimer s to predict patient outcomes and determine how potential therapeutics are delivered to the CNS There are currently few companies able to offer multi organ evaluation with a recirculating medium utilizing functional readouts and none ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Clinical Study of an Extended Patency Dialysis Access Graft

    SBC: HEALIONICS CORPORATION            Topic: 300

    Clinical Study of an Extended Patency Dialysis Access Graft PROJECT SUMMARY Objective The goals of this PAR Clinical Studies Fast Track SBIR proposal are to move a novel hemodialysis access graft design to k submission and upon k clearance conduct a patient clinical study to demonstrate improved performance compared to current synthetic grafts which have high rate of clot ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Integration of a kidney module into a organ human on a chip system

    SBC: Hesperos, Inc            Topic: 400

    Project Summary Our overall strategy for Hesperos is to utilize microphysiological systems in combination with functional readouts to establish platforms capable of sophisticated analysis of chemicals and drug candidates for toxicity and efficacy during pre clinical testing with initial emphasis on predictive toxicity This is a service based company and is developing low cost in vitro systems u ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Preclinical characterization of THR to induce pancreatic beta cell regeneration Phase I

    SBC: Ophysio Inc.            Topic: NIDDK

    The exocrine acinar ductal compartment of the pancreas has been hypothesized to harbor progenitor cells with the ability to give rise to new b cells The activation of such progenitors may potentially result in new b cell formation through differentiation rather than reprogramming We hypothesized that if pancreatic progenitors existed they would respond to bone morphogenetic protein BMP ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Low Cost Catalytic Biomass Cookstove for Improved Indoor Air Quality

    SBC: MAINSTREAM ENGINEERING CORPORATION            Topic: NIEHS

    Project Summary An estimated billion people or about one third of the world s population rely on biomass fuel for cooking Emissions from biomass cookstoves contribute to global climate change indoor local air quality issues and related health effects In particular indoor air quality issues related to biomass cookstoves contribute significantly to rates of acute respiratory infection Re ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health

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