List

For best search results, use the search terms first and then apply the filters
Reset

The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Development of novel Ku targeted kinase inhibitors

    SBC: NERX BIOSCIENCES, INC.            Topic: 102

    Title Development of novel Ku targeted kinase inhibitors Abstract DNA PK the DNA dependent protein kinase is a validated target for cancer therapeutics that drives the DNA damage response and plays a critical role in the non homologous end joining NHEJ DNA repair pathway NHEJ is responsible for the repair of DNA double strand breaks DSB particularly those induced by ionizing radiati ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Detection quantitation and analysis of extracellular vessicles using reflective phase grating technology

    SBC: CYTOMICS ANALYTICAL, LLC            Topic: NIDA

    Over the past or years it has become clear that extracellular vesicles EVs play a far more important role in patient physiology than previously thought There are now numerous examples of studies showing that EVs have a role in cell cell communication in neuronal cells may be involved in drug transport across the blood brain barrier and impact a variety of signaling mechanism because ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. A Novel Probiotic Platform to Treat Necrotizing Enterocolitis

    SBC: Monon Bioventures LLC            Topic: 300

    PROJECT SUMMARY Probiotics hold enormous potential for promoting human health and treating disease One major hurdle to many probiotic products is their lack of persistence in the gut Monon Bioventures MBV and their research partners at the Research Institute at Nationwide Childrenandapos s Hospital RINCH are developing a novel enhanced tunable technology called ProNextTM that allows for a ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Developing Testing and Validating a Wearable Alcohol Biosensor

    SBC: Clinitech, LLC            Topic: 450

    PROJECT SUMMARY This application for a Phase I SBIR award represents a collaboration between Clinitech LLC and McLean Hospital Harvard Medical School to develop a wearable biosensor for detecting alcohol in the interstitial fluid of humans who have consumed alcohol Excessive use of alcohol accounts for much of the public health burden related to alcohol use disorders including fetal ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Next generation quantitative HCV drug resistance assay

    SBC: Medosome Biotec, LLC            Topic: 300

    Project Summary Abstract The objective of this Phase I STTR application is to develop a next generation quantitative drug resistance assay that can accurately determine the abundance and linkage of HCV variants resistant to direct antiviral agents DAAs Drug resistance to HCV is a major threat to achieving sustained virologic response SVR in HCV infected individuals RAVs pre exist in patients ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Development of CaSR nutrient therapy for childhood diarrhea

    SBC: Medosome Biotec, LLC            Topic: NICHD

    Project Abstract Acute infectious diarrhea is a worldwide problem especially among infants young children and immune compromised patients Sadly million children die each year not because of the infections causing diarrhea but due to the associated dehydration The pro absorptive Oral Rehydration Solution ORS is the only recommended oral therapy for children with acute diarrhea yet it ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Tools to Measure Non Receptor Tyrosine Kinase Activities for Drug Discovery and Biomarker Analysis

    SBC: Kinasense LLC            Topic: 102

    Project Abstract Advanced cell based technologies for kinase activity profiling are needed for earlier identification of next generation kinase inhibitors and to enable clinical evaluation of kinase activity biomarkers The long term goal of this proposal is to generate targeted kinase activity tests compatible with viable cells from patient derived samples The objectives in this proposal work t ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Wearable technology to reduce risk of DVT and increase patient compliance

    SBC: RECOVERY FORCE, LLC            Topic: NHLBI

    Project Abstract Deep Vein Thrombosis DVT is a condition wherein a blood clot forms in a vein of the deep system These clots can break loose travel through the blood stream and into the lungs causing pulmonary embolism PE This is life threatening and requires immediate medical care Each year in the United States between and people get a blood clot in the legs or in the lun ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Point of care immunoassay for rapid diagnosis of tinea capitis

    SBC: DxDiscovery Incorporated            Topic: NIBIB

    Tinea capitis scalp ringworm is a fungal dermatophyte infection of scalp hair follicles that afflicts of the U S pediatric population Tinea capitis is a major health care disparity because it occurs predominantly among individuals with a disadvantaged socioeconomic background and sub Saharan African descent Diagnosis of tinea capitis is currently dependent on culture and microscopy Both ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government