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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. In Vitro Culture of Plasmodium falciparum Sporozoites for Malaria Vaccine

    SBC: SANARIA INC.            Topic: R

    DESCRIPTION provided by applicant Sanariaandapos s platform technology is production of aseptic purified cryopreserved Plasmodium falciparum Pf sporozoites SPZ This technology has produced three products administered by needle and syringe all of which are in clinical trials PfSPZ Vaccine radiation attenuated PfSPZ PfSPZ Challenge infectious PfSPZ for controlled human malaria infec ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Genetically Attenuated PfSPZ Malaria Vaccine

    SBC: SANARIA INC.            Topic: R

    DESCRIPTION provided by applicant We build on the successful work in Phase II SBIR R AI in which a genetically attenuated Plasmodium falciparum Pf parasite GAP was produced and shown to generate aseptic Pf sporozoites SPZ that invade hepatocytes but do not replicate We will use this genetically attenuated double mutant parasite deficient in the genes encoding SLARP and B Pf ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Plasmodium Falciparum Whole Sporozoite Malaria Vaccine

    SBC: SANARIA INC.            Topic: NIAID

    DESCRIPTION provided by applicant The ideal tool for eliminating Plasmodium falciparum Pf the causative agent of of all malaria deaths would be a highly effective vaccine that prevents blood stage infection and thereby prevents the disease and transmission The only immunogens demonstrated in humans to be able to induce andgt protective efficacy that is sustained months are ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  4. Plasmodium Falciparum Whole Sporozoite Malaria Vaccine

    SBC: SANARIA INC.            Topic: NIAID

    DESCRIPTION provided by applicant The ideal tool for eliminating Plasmodium falciparum Pf the causative agent of of all malaria deaths would be a highly effective vaccine that prevents blood stage infection and thereby prevents the disease and transmission The only immunogens demonstrated able to induce andgt sustained months protective efficacy in humans are Pf sporozoit ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  5. Phase IIa study of VBP for Duchenne muscular dystrophy

    SBC: ReveraGen BioPharma, Inc.            Topic: 106

    DESCRIPTION provided by applicant ReveraGen BioPharma is a clinical stage drug development company that is developing VBP a novel dissociative steroidal class drug The initial indication for development is Duchenne muscular dystrophy where VBP holds promise for retaining or increasing efficacy of glucocorticoids while reducing side effects bone fragilit stunting of growth VBP is c ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Optimization of a Therapeutic HIVSIV Multi Antigen DNA Vaccine

    SBC: PROFECTUS BIOSCIENCES, INC.            Topic: R

    DESCRIPTION The HIV pandemic is one of the greatest public health challenges in history It is estimated that million people are living with HIV and million of those are newly infected In a number of developed countries the risk of death associated with HIV infection has sharply declined due to the use of highly active antiretroviral therapy HAART Unfortunately the rate of new HIV i ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Pilot Human Study Using Transnasal Cooling on Cardiac Arrest Subjects

    SBC: KEY TECHNOLOGIES INC            Topic: NHLBI

    DESCRIPTION provided by applicant This project will result in the creation of a clinical grade product called the CoolStat that will be able to quickly and safely cool the brain and body after cardiac arrest The CoolStat is designed to be initiated by EMS personnel to start early cooling post arrest which has been shown to improve survival rates and neurological outcomes As part of this over ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Optimization of a DNA Subunit Regimen for an HIV Vaccine

    SBC: PROFECTUS BIOSCIENCES, INC.            Topic: NIAID

    DESCRIPTION provided by applicant Our primary approach to develop an effective prophylactic vaccine against HIV utilizes a novel immunogen called the Full Length Single Chain FLSC that consists of gp derived from HIV BaL genetically linked via a amino acid linker to the D D domains of human CD Rhesus macaques were inoculated with rhFLSC a surrogate version of FLSC that contains CD derived from rhe ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  9. Attend BIO conference to meet with potential commercialization partners for ultra-fast MRI technology

    SBC: Weinberg Medical Physics, Inc.            Topic: NINDS

    DESCRIPTION provided by applicant This application represents a competing renewal request for a Phase II STTR project in which we constructed an ultra fast gradient system for magnetic resonance imaging Operation of the novel system is based upon the principle that the nervous system is relatively insensitive to very short exposures to changing magnetic fields As a result we are showing in ...

    STTR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
  10. An Intuitive Prosthetic System for Upper Extremity Amputees

    SBC: Infinite Biomedical Technologies, LLC            Topic: 102

    DESCRIPTION provided by applicant There are well over people living with upper limb loss in the United States today and in new amputations are of the upper limb The loss of an upper limb is devastating to a personandapos s quality of life their work productivity and it bring about many psychosocial challenges While there have been exciting technological advances which promise th ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health

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