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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Developing Nanopieces, a Platform RNAi Delivery Technology for Treatment of Multiple Diseases

    SBC: Nanode Therapeutics, Inc.            Topic: NCATS

    STTR_Developing Nanopieces 7. Project Summary/Abstract The bottleneck of developing new RNAi (RNA Interference) drugs is the lack of highly efficient and non-toxic RNA delivery to non-liver tissues in vivo. It is especially challenging to deliver negatively-charged nucleic acid into avascular, dense, and negatively-charged matrix in hard-to-reach tissues including joint cartilage. NanoDe Therapeut ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  2. Cryopreservation of Anopheles Embryos

    SBC: SANARIA INC.            Topic: NIAID

    ABSTRACT: PfSPZ Vaccine is currently on track to be the world’s first licensed vaccine against malaria and the first vaccine against a human parasitic disease. PfSPZ Vaccine is composed of aseptic, attenuated, metabolically active, purified, vialed and cryopreserved Plasmodium falciparum (Pf) sporozoites (SPZ). Manufacture of PfSPZ Vaccine shares all steps (except radiation attenuation) with PfS ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  3. Development of Intact Proviral DNA Assays for SIV and SHIV

    SBC: Accelevir Diagnostics, LLC            Topic: NIAID

    PROJECT SUMMARY/ABSTRACTHuman immunodeficiency virus type-1 (HIV-1) is a retrovirus that infects CD4+ T cells of the immune system. If left untreated, HIV-1 infected individuals will progress to AIDS and may ultimately die as a result. Combination antiretroviral therapy is extremely effective at stopping the replication of HIV-1 in infected individuals. Despite the success of this therapy at suppr ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  4. Multivalent Adjuvant Immunization to Prevent Hospital Acquired Infections

    SBC: EXBAQ LLC            Topic: NIAID

    PROJECT SUMMARY According to the CDC, 550,000 Healthcare Associated Infections (HAIs) occur per year in the US, costing ~$100 billion and killing tens of thousands of patients. Reducing HAIs is a top priority of the US DHHS and NIH and experts have called for novel strategies including vaccination to achieve this goal.ExBaq was founded by scientists and business colleagues who have spent years stu ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  5. Directed evolution of N-terminal amino acid binding proteins for application to protein sequencing

    SBC: ENCODIA, INC.            Topic: 300

    ABSTRACT More accessible and cost-effective technologies for analysis of the proteome would accelerate biological and medical research. The goal of this proposal is to develop a highly-scalable digital protein analysis technology. The approach is broadly applicable and greatly improves upon cost, sensitivity, usability, and throughput of current approaches.NARRATIVE This proposal is to develop tec ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  6. Feelix @ Home: Testing and optimization of a smart stethoscope for home use to monitor changes in lung status of individuals with chronic conditions

    SBC: SONAVI LABS INC            Topic: NHLBI

    Project SummaryThe goal of this project is to further develop an existing smart stethoscope in order to be capable of monitoring pediatric patients at home who suffer from asthma as well as adults with COPD. Lung diseases impose a serious burden on healthcare systems, individuals and governments. The World Health Organization (WHO) found that chronic obstructive pulmonary disease (COPD) and lower ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  7. An additive solution optimized for anaerobic (hypoxic) RBC storage to minimize storage lesion development.

    SBC: NEW HEALTH SCIENCES, INC.            Topic: NHLBI

    The objective of this project is to develop an additive solution optimized for red blood cells (RBCs) stored under hypoxic environment, with the goal of producing highest quality RBCs by minimizing storage- associated damage (storage lesion). The additive solution developed in this project will be commercialized as a part of the Hemanext hypoxic storage platform. The proposal builds on the strong ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  8. Third line treatment of drug resistant FLT3-positive acute myeloid leukemia with a novel FLT3 kinase inhibitor

    SBC: KinaRx, LLC            Topic: 102

    Project Summary Acute myeloid leukemia (AML) is one of the most challenging malignancies with the 5-year survival for younger and medically fit patients hovering around the 30% mark for over 3 decades. About 30% of AML patients harbor activating mutations in FLT3 kinase that are associated with very poor prognosis. The non-specific tyrosine kinase inhibitor (TKI) Midostaurin was approved in 2017 f ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  9. Bloodstream infection detection directly on whole blood

    SBC: SCANOGEN INC.            Topic: NIAID

    Bloodstream infection detection directly on whole blood Summary Sepsis is a life-threatening condition triggered by the presence of fungi or bacteria in the bloodstream that affects 1.3 million people each year in the United States.1 Rapid antimicrobial administration is critical for sepsis treatment.2-4 However, the current gold standard for bloodstream infection diagnosis is blood culture (BC), ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  10. Novel therapeutic for treatment of type 1 diabetes

    SBC: Veralox Therapeutics Inc.            Topic: NIDDK

    The incidence of type 1 diabetes (T1D) has been increasing in the US for reasons that remain elusive. The Centers for Disease Control and Prevention (CDC) reports that T1D is the third most prevalent chronic disease of childhood in the USA, behind asthma and obesity. Approximately 5% of the 30.3 million adults with diabetes in the USA have T1D. The pathogenesis of T1D encompasses a spectrum that r ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
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