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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Development of an adenosine A1 receptors agonist, MRS5474 for the treatment of chronic depression

    SBC: Primetime Life Sciences, LLC            Topic: 101

    Depression is a common mental disorderwhich can be chronic or recurrentmarkedly tarnishing a person s ability to function in their normal lifePeople with a depression can feel emptysadhelplessrestlesshopelessanxiousworthlessguiltyirritableashamed or suicidalThey may lose interest in routine work or physical activitiesThey show appetite disorderproblems concentratingremembering details or making de ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Infection Site Targeted Antitoxin Antibody (ISTAb) against Bacillus anthracis

    SBC: Integrated Biotherapeutics, Inc.            Topic: NIAID

    Project Summary Bacillus anthracisBais a Gram positive spore forming bacterium that is listed as an agent of highest concernCategory Aby NIAID and CDCBa is easy to growand its spores can be formulated into highly stable powder form and disseminated as aerosol or used to contaminate food or waterInletters laced with powdered anthrax spores were mailed to several US politiciansTwenty two peopleinclu ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Towards virtual laboratory for optimizing cardiac rhythm

    SBC: CARDIOSOLV ABLATION TECHNOLOGIES, INC.            Topic: NHLBI

    PROJECT SUMMARY CardioSolv Ablation TechnologiesInchas developed and aims to commercialize a simulation based approach for non invasive prediction of the optimal targets of catheter ablation in patients with infarctrelated ventricular tachycardiaSuccessful completion of the commercialization will result in a major paradigm shift in the clinical procedure of ventricular tachycardia ablationwhere ac ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Automated 3D Ultrasound-based Surveillance of Arteriovenous Fistula Maturation for Post-operative Hemodialysis Patients

    SBC: Sonavex, Inc.            Topic: NHLBI

    PROJECT SUMMARY ABSTRACT Severe kidney disease accounts forof all Medicare and Medicaid costsThe most cost effective way to perform dialysis uses an arteriovenous fistula to connect to dialysis machinesbut fistula use is limited by the malfunctions immediately following creationmaturation failurewhich can render up toof all created fistulas unusableUltrasound monitoring of the fistula after it has ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Development of VLP vaccine for RSV

    SBC: SIGMOVIR BIOSYSTEMS, INC.            Topic: NIAID

    Respiratory syncytial virusRSVis a significant human pathogen severely impacting neonates and young childrenbut no vaccine exists to protect this vulnerable populationFurthermoredirect vaccination of neonates is likely ineffective due to the immaturity of their immune systemand neonate immunization is potentially unsafeThe current view is that maternal vaccination is the best and safest approach t ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. OPTIMIZATION AND ASSESSMENT OF A BIOLOGIC TO IMPROVE FUNCTIONAL RECOVERY AFTER PERIPHERAL NERVE INJURY

    SBC: Alcamena Stem cell Therapeutics, LLC            Topic: NINDS

    ABSTRACTPeripheral nerve injuryPNIis a common and challenging clinical problem affecting overof U Strauma patientsAmong combat traumathe rate of PNI increases toThese patients require extensive resources for initial treatment and therapyyet they are still left with functional disabilityCurrent treatments for motorsensoryand mixed PNI include nerve autografts and axonal guidance tubesHoweverthese m ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Low Cost Image Guidance for Improved Vessel Cannulation in Pediatric Patients

    SBC: Clear Guide Medical, Inc.            Topic: NICHD

    The use of ultrasound for placement of many IVs in pediatric cases has significantly enhanced the success of Central Vein Catheterizationsandquot CVCsandquotalthough ultrasound can often be hard for nonspecialists to useAlthough ultrasound guidance can certainly facilitate vascular accessit takes practice and experience to master the real time ultrasoundfree hand techniqueThe value of this SBIR pr ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. User-driven Retrospectively Supervised Classification Updating (RESCU) system for robust upper limb prosthesis control

    SBC: Infinite Biomedical Technologies, LLC            Topic: 105

    ABSTRACT Approximatelyindividuals live with upper limb lossloss of at least one handin the USFortunatelyprosthetic devices have advanced considerably in the past decades with the development of dexterousanthropomorphic handsHoweverpotentially the most promising used control strategymyoelectric controllacks a correspondingly high level of performance and hence the use of dexterous hands remains hig ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Novel Long Acting rhTSH Superagonist Analogs for Improved Diagnostic Imaging, Thyroglobulin Stimulation and Therapy of Thyroid Cancer.

    SBC: TROPHOGEN INC            Topic: 102

    Thyroid cancer is the most common malignancy of endocrine tissuesdisproportionally affecting womenand is one of the few cancers greatly increasing in incidence andampprevalence for unknown reasonsA very aggressive form of this cancer may result from nuclear accidents like Chernobyl andampFukushimaincreasing proximity of nuclear waste storage sitesor from nuclear explosions including those that cou ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. TB Diagnostics at the Point of Care

    SBC: AKONNI BIOSYSTEMS INC.            Topic: NIAID

    ABSTRACT Tuberculosis ranks in the top ten worldwide cause of death and now ranks ahead of HIVmaking it the number one infectious disease killerPerhapsmost alarming is the global prevalence of multidrug resistant TBMDRTBand extensively drug resistant TBXDR TBmore thanof new TB cases are MDR TB andof these have XDR TBAndthe number of enrolled XDR TB cases has grown fromcountries intoinThe concern t ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health

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