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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 1 - 10 of 8890 results
  1. AAV-AIBP Therapy for Alzheimer's Disease

    SBC: RAFT PHARMACEUTICALS LLC            Topic: NIA

    PROJECT SUMMARY Therapy for Alzheimer’s disease and related dementias (AD/ADRD), slow-progressing neurodegenerative diseases, remains elusive. Therapeutic approaches focusing on beta amyloid (Aβ) removal from the brain or on targeting genes for which strong associations between their polymorphism and AD/ADRD are established, have had a mixed record of success. We propose a novel strategy to rev ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  2. ABC Transporters as Pharmaceutical Targets

    SBC: PLEXXIKON, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): ABC transporters pump a variety of small molecules and peptides across cell membranes. Mutations in ABC transporter genes cause severe defects in man. Drugs that modulate ABC transporter function would have utility as anti-microbials through inhibition of essential microbial ABC transporters, as well as in the states of atherosclerosis, macular degeneration, di ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  3. A Bedside Relational Agent to Improve Hematopoietic Cell Transplantation Outcomes in Cancer Patients

    SBC: CARE.COACH CORPORATION            Topic: 101

    Abstract Deliriuma major cause of fallscan occur in as many asof cancer patients undergoing stem cell transplantationresulting in up totimes greater chance of dyingDelirium risk can be mitigated and many other outcomes of stem cell transplants can be improved through behavioral interventions delivered at the bedside through conversationimageryand audioHowevertraditional means of delivering these i ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. A Bedside Relational Agent to Improve Hematopoietic Cell Transplantation Outcomes in Cancer Patients

    SBC: CARE.COACH CORPORATION            Topic: 101

    Abstract Delirium, a major cause of falls, can occur in as many as 50% of cancer patients undergoing stem celltransplantation, resulting in up to 14 times greater chance of dying. Delirium risk can be mitigated and manyother outcomes of stem cell transplants can be improved through behavioral interventions delivered at thebedside through conversation, imagery, and audio. However, traditional means ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  5. A Better Mechanism for Controlled Nanopore Translocation

    SBC: ELECTRONIC BIOSCIENCES, INC.            Topic: 172

    Project Summary Enabling high accuracy nanopore based strand sequencing has the potential to improve the understanding of long range genomic relationships and processes andbased on its accessibilityenable the associated clinical and diagnostic applicationsthe fastest growing sequencing sectorUnfortunatelyit is commonplace for nanopore sequencing error rates to exceedand higher accuracy is needed t ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. A Biological Assessment System for Cognitive Persistence

    SBC: BIOASSESSMENTS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The low frequency cardiac rhythm (LFCR) is an innovative, but underutilized, biological marker. The PI's studies show that LFCR is strongly associated with the state of cognitive persistence in controls. Cognitive persistence refers to the ability to remain on-task and inhibit impulsive off-task behavior. Additional preliminary data also suggest that children w ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  7. A Biological Assessment System for Cognitive Persistence

    SBC: BIOASSESSMENTS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The low frequency cardiac rhythm (LFCR) is a promising biological marker for psychological research. The primary goal of this project is to make the LFCR methodology more accessible to researchers by providing a both a product and extensive support services. In Phase I, a prototype system was built and used to collect simultaneous physiological and cognitive da ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  8. A Biological Small Angle X-ray Scattering Station (BioSAXS) for the Compact Light

    SBC: LYNCEAN TECHNOLOGIES, INC.            Topic: NIGMS

    7. Project Summary/Abstract We propose to develop a Biological Small-angle X-ray Scattering (BioSAXS) station for the Compact Light Source, a powerful new generation of X-ray sources, which will enable biologists and biochemists to pursue state-of-the-artresearch in macromolecular structure studies in their own laboratories. The frontier of structural biology is the determination of large macromol ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Ablation Fiber Optic Probe for Surgical Maze Procedure

    SBC: INTELLIGENT OPTICAL SYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is a heart rhythm abnormality that involves irregular, and often rapid heartbeats. Billions of dollars are spent annually to diagnosis and treat this disorder. Recent studies demonstrate the feasibility of treating AF and other structural heart diseases with limited, left-atrial ablation lesion sets, using alternative energy sources ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  10. A Bone Quality Diagnostic Instrument for the Improved Assessment of Fracture Risk

    SBC: ACTIVE LIFE SCIENTIFIC INC            Topic: NIA

    DESCRIPTION (provided by applicant): Osteoporosis is a major medical problem affecting over 44 million individuals in the US, and a substantial number of those individuals will experience a low impact fracture. To effectively assess fracture risk in thispopulation, one must be able to directly measure bone quality parameters in a patient that reflects the overall mechanical competence of the bone ...

    SBIR Phase I 2012 Department of Health and Human ServicesNational Institutes of Health
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