Award Data

Each day, more than 100,000 patients undergo general anesthesia in the United States. The current practice of general anesthesia is prone to over-sedating patients, either due to the lack of brain monitoring or using brain monitors with inaccurate indices. Over-sedation (at 28% incidence) contributes to perioperative neurocognitive disorders (PNDs) in elderly population (≥65yrs). The cost of PND ...

While total joint replacement prostheses have been a great success for over 80 years in providing mobility to patients with osteoarthritis, post-surgery complications like aseptic loosening, dislocation and infections remain as problems, often leading to costly and complicated revision surgery. The objective of this proposal is to address implant dislocation, the second most common complication fo ...

PROJECT SUMMARY/ABSTRACT The application’s broad objective is to create a product that is able to improve remote compliance monitoring in pediatric orthotics applications by creating a device that combines all of the ideal compliance monitoring features into a single device called the Unintrusive Pediatric Logging Orthosis Analytic Device (UPLOAD). Our initial focus is on pediatric orthotic popu ...

Necrotizing enterocolitis (NEC) is a devastating acute inflammatory condition of the gastrointestinal tract resulting in intestinal necrosis, systemic sepsis and multi-system organ failure found mostly in infants born prematurely. Despite modern medical advances in the past decade, the etiology remains elusive and morbidity and mortality are still unacceptably high. It has been concluded that the ...

7. Project Summary ADRD dementias account for up to 25% of all dementias in patients older than 65 years and there is strong evidence of co-morbid pathologies caused by (amyloid β (Aβ), tau and α-synuclein (αSyn). The degree of AD- related pathology in Lewy Body Dementias (LBD) is moderate or severe in 50% of PDD and more than 70% of DLB patients have concomitant AD-related pathology so that t ...

ABSTRACT Between half and three-quarters of nursing home (NH) residents fall each year. About 5% of adults 65 and older live in nursing homes, but nursing home residents account for 20% of deaths from falls in this age group. 50% of nursing home residents have moderate or severe cognitive impairment. Older adults with Alzheimer’s Disease or ADRD are more likely to fall than their peers without c ...

PROJECT SUMMARY It has been shown that conversations on end-of-life care focused on a patient’s goals of care can reduce psychological distress and anxiety and lead to improved quality of life, and potentially prolonged life, for patients living with serious illness. The Serious Illness Conversation Guide (SICG) is a validated and widely used framework for training the critical communication ski ...

Abstract Status epilepticus (SE) is a common neurologic emergency that fails to respond to first- and second-line anti-seizure medications (ASMs) in about one third of instances, thus progressing to refractory SE (RSE). Patients with RSE are at grave risk for neurological morbidity and mortality. The recently completed NIH-funded Established SE Treatment Trial (ESETT) highlights the need for impro ...

PROJECT SUMMARY / ABSTRACT There are more than 230,000 new cases of lung cancer and over 130,000 deaths due to lung cancer each year in the U.S. Approximately 120,000 people each year will present with metastatic Non-Small Cell Lung Cancer (mNSCLC) for the first time, and only 7% of these patients will survive five years or more. accurius is developing the first of a kind inhalable agent that will ...

Project Summary/AbstractProteasome inhibitors (PIs) are one of the most important classes of therapeutics to have emerged in the past two decades and now serve as the backbone of multiple myeloma (MM) treatment. The first-in-class PI, bortezomib (Btz), targets the ubiquitin proteasome pathway (UPP), which has led to tremendous efficacy in inducing plasma cell apoptosis and in inhibiting MM growth. ...