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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. In Vitro Culture of Plasmodium falciparum Sporozoites for Malaria Vaccine

    SBC: SANARIA INC.            Topic: R

    DESCRIPTION provided by applicant Sanariaandapos s platform technology is production of aseptic purified cryopreserved Plasmodium falciparum Pf sporozoites SPZ This technology has produced three products administered by needle and syringe all of which are in clinical trials PfSPZ Vaccine radiation attenuated PfSPZ PfSPZ Challenge infectious PfSPZ for controlled human malaria infec ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Genetically Attenuated PfSPZ Malaria Vaccine

    SBC: SANARIA INC.            Topic: R

    DESCRIPTION provided by applicant We build on the successful work in Phase II SBIR R AI in which a genetically attenuated Plasmodium falciparum Pf parasite GAP was produced and shown to generate aseptic Pf sporozoites SPZ that invade hepatocytes but do not replicate We will use this genetically attenuated double mutant parasite deficient in the genes encoding SLARP and B Pf ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Plasmodium Falciparum Whole Sporozoite Malaria Vaccine

    SBC: SANARIA INC.            Topic: NIAID

    DESCRIPTION provided by applicant The ideal tool for eliminating Plasmodium falciparum Pf the causative agent of of all malaria deaths would be a highly effective vaccine that prevents blood stage infection and thereby prevents the disease and transmission The only immunogens demonstrated in humans to be able to induce andgt protective efficacy that is sustained months are ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  4. Plasmodium Falciparum Whole Sporozoite Malaria Vaccine

    SBC: SANARIA INC.            Topic: NIAID

    DESCRIPTION provided by applicant The ideal tool for eliminating Plasmodium falciparum Pf the causative agent of of all malaria deaths would be a highly effective vaccine that prevents blood stage infection and thereby prevents the disease and transmission The only immunogens demonstrated able to induce andgt sustained months protective efficacy in humans are Pf sporozoit ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  5. SBIR TOPIC 096: Novel Biodegradable Metal Stents for Neonatal Aortic Coarctation

    SBC: PediaStent LLC            Topic: NHLBI

    Most stents used to repair congenital heart lesions only need to serve as temporary scaffoldingsBecause pediatric patients have growing cardiovascular structuresthere is great interest in use of bioresorbable stentsBRSfor the treatment of coarctation of the aorta in neonatesA pediatric bioresorbable stent would allow thousands of infants each year to avoid the morbidity and mortality of more invas ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Phase IIa study of VBP for Duchenne muscular dystrophy

    SBC: ReveraGen BioPharma, Inc.            Topic: 106

    DESCRIPTION provided by applicant ReveraGen BioPharma is a clinical stage drug development company that is developing VBP a novel dissociative steroidal class drug The initial indication for development is Duchenne muscular dystrophy where VBP holds promise for retaining or increasing efficacy of glucocorticoids while reducing side effects bone fragilit stunting of growth VBP is c ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Miniature Stimulator for Temporary Therapies

    SBC: SPR THERAPEUTICS, INC.            Topic: NICHD

    DESCRIPTION provided by applicant The goal of this project is to collect the safety and effectiveness clinical data necessary to commercialize the SMARTPATCH R system for post stroke shoulder pain PSSP The prevalence of stroke is approximately million in the US with additional persons surviving a stroke each year Moderate to severe shoulder pain develops in a quarter to a third ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Optimization of a Therapeutic HIVSIV Multi Antigen DNA Vaccine

    SBC: PROFECTUS BIOSCIENCES, INC.            Topic: R

    DESCRIPTION The HIV pandemic is one of the greatest public health challenges in history It is estimated that million people are living with HIV and million of those are newly infected In a number of developed countries the risk of death associated with HIV infection has sharply declined due to the use of highly active antiretroviral therapy HAART Unfortunately the rate of new HIV i ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Pilot Human Study Using Transnasal Cooling on Cardiac Arrest Subjects

    SBC: KEY TECHNOLOGIES INC            Topic: NHLBI

    DESCRIPTION provided by applicant This project will result in the creation of a clinical grade product called the CoolStat that will be able to quickly and safely cool the brain and body after cardiac arrest The CoolStat is designed to be initiated by EMS personnel to start early cooling post arrest which has been shown to improve survival rates and neurological outcomes As part of this over ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Optimization of a DNA Subunit Regimen for an HIV Vaccine

    SBC: PROFECTUS BIOSCIENCES, INC.            Topic: NIAID

    DESCRIPTION provided by applicant Our primary approach to develop an effective prophylactic vaccine against HIV utilizes a novel immunogen called the Full Length Single Chain FLSC that consists of gp derived from HIV BaL genetically linked via a amino acid linker to the D D domains of human CD Rhesus macaques were inoculated with rhFLSC a surrogate version of FLSC that contains CD derived from rhe ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health

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